Cleveland Clinic’s Sarcoma Program is a national and international resource for the diagnosis and treatment of adults and children with benign and malignant tumors of the bone and soft tissue.

The multidisciplinary sarcoma clinic is designed to provide you with the medical opinions of sarcoma specialists from different disciplines in a single location.  Sarcoma surgeons, medical oncologists, radiation oncologists, radiologists and pathologists come together to review patients with malignant and benign bone and soft tissue tumors. These sarcoma specialists are experienced in the care of complex, challenging tumors. Together, they will come up with the treatment plan most likely to result in the best possible outcome and quality of life.  Our team of pediatric solid tumor specialists also work together to treat children, adolescents, and young adults with rare and common varieties of cancer that occur in young people.

People who develop cancer of the bone or surrounding soft tissue can take comfort in Cleveland Clinic's expertise with musculoskeletal cancers. Although bone tumors are relatively rare, our specialists treat hundreds of people with benign and malignant tumors each year in one of the largest programs in the United States.

In the past, bone cancer often led to amputation. Today, our bone cancer specialists have reversed that trend with limb-sparing surgery at Cleveland Clinic. More than 90 percent of our patients with bone cancer can avoid amputation with only a small chance of recurrence.

Cleveland Clinic is ranked as one of the nation’s top hospitals by U.S. News & World Report.

What We Treat

What We Treat

Malignant Tumors

Benign Bone Tumors

  • Benign Bone Tumors
  • Blood Cell Tumors
    • Osteosclerotic Myeloma
    • Solitary Bone Plasmacytoma
  • Cartilage Tumors
    • Chondroblastoma
    • Chondromyxoid Fibroma
    • Multiple Enchondromatosis (Ollier's Disease, Maffucci's Syndrome)
    • Multiple Hereditary Exostosis
    • Periosteal Chondroma
    • Solitary Enchondroma
    • Solitary Osteochondroma
  • Conditions Which Can Be Mistaken For Tumors
  • Fibrogenic & Histiocytic Tumors
    • Desmoplastic Fibroma
    • Histiocytoma/Benign Fibrous Histiocytoma
    • Multiple non-ossifying fibromas (Jaffe-Campanacci Syndrome, Familial Multifocal NOF)
    • Solitary non-ossifying fibroma
  • Giant Cell Tumor (also known as Osteoclastoma)
  • Osseous Tumors
    • Osteoblastoma
    • Osteoid Osteoma
  • Reactive Lesions
    • Aneurysmal Bone Cyst
    • Unicameral Bone Cyst
  • Tumor-like Lesions
    • Bone Infarct
    • Bone Island (also known as Enostosis)
    • Brown Tumor of Hyperparathyroidism
    • Eosinophilic Granuloma
    • Fibrodysplasia Ossificans Progressiva (Munchmeyer's Disease)
    • Fibrous Dysplasia (McCune Albright Syndrome, Mazabraud Syndrome, Osteofibrous Dysplasia)
    • Focal Fibrocartilaginous Dysplasia
    • Heterotopic Ossification
    • Myositis Ossificans
    • Melorheostosis
    • Osteofibrous Dysplasia (also known as Ossifying Fibroma, Campanacci Lesion)
    • Paget's Disease
    • Synovial Osteochondromatosis
    • Tumoral Calcinosis
  • Vascular Tumors
    • Hemangioma of Bone 

Benign Soft Tissue Tumors

  • Benign Soft Tissue Tumors
  • Fatty Tumors
    • Angiolipoma
    • Hibernoma
    • Intramuscular Lipoma
    • Pleomorphic Lipoma
    • Spindle Cell Lipoma
  • Fibrogenic Tumors
    • Calcifying Aponeurotic Fibroma
    • Extra-abdominal Desmoid Tumor (Familial Adenomatous Polyposis, Gardner Syndrome)
    • Nodular Fasciitis
    • Plantar Fibromatosis (Ledderhose Disease)
  • Muscular Tumors
    • Intramuscular Myxoma (Mazabraud's Syndrome)
  • Peripheral Nerve Tumors
    • Neurilemmoma (also known as Schwannoma)
    • Neurofibromatosis
    • Neuroma (including Morton's Neuroma)
    • Sporadic Neurofibromas
  • Synovial Tumors
    • Giant Cell Tumor of Tendon Sheath
    • Pigmented Villonodular Synovitis
    • Synovial Chondromatosis
  • Vascular Tumors
    • Glomus Tumor (also known as Paraganglioma)
    • Intramuscular Hemangioma

Treatment Options

For Additional Information

Care Team Support & Services

Support & Services

Patient Services

In addition to offering state of the art diagnostic techniques and sarcoma treatment methods, our sarcoma specialists offer an array of resources that can help patients cope with the demands of cancer. Patients are encouraged to take advantage of these resources to ease the burden of managing cancer.

Race to Cure Sarcoma | Cleveland Clinic

The Race to Cure Sarcoma helps raise both awareness and resources for sarcoma research nationally through the Sarcoma Foundation of America and locally through Cleveland Clinic. To learn more, watch this video and visit this web site for more information on this year's race.

Patient Testimonials

Related Content

Clinical Trials & Research

Clinical Trials & Research

Cleveland Clinic Cancer Center clinical trials offer patients important sarcoma treatment options and access to the latest treatments and procedures resulting from cancer research.

Clinical Trials

Clinical trials (or research studies) help us create the medicine of tomorrow. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are widely available.

We can help you access hundreds of clinical trials across all specialty areas. Our new searchable online trials tool makes identifying treatment opportunities easier than ever.

Medical Professionals

Medical Professionals

Cleveland Clinic Cancer Center is committed to working with you to provide the best care for your patients. Our team is also dedicated to the training and education of medical professionals to advance cancer care and research.

Pathology Second Opinion

Cleveland Clinic Laboratories offers second opinion pathology consultations for surgical pathology, cytology, and hematopathology cases.


Make An Online Referral to Cleveland Clinic Cancer Center

To make a direct online referral to Cleveland Clinic Cancer Center, complete our Online Cancer Patient Referral Form or visit clevelandclinic.org/cancerpatientreferrals.

You will receive confirmation once the appointment is scheduled.

Surgical Referrals

To refer a surgical patient, please contact our Referring Physician Hotline, available 24 hours a day, 7 days a week, for all your needs, by calling 855.REFER.123 (855.733.3712).

National Ewing Sarcoma Tumor Board

Cleveland Clinic and Cleveland Clinic Children’s are hosting an educational National Ewing Sarcoma Tumor Board in collaboration with sarcoma experts across the nation.

Our mission is to provide expertise and education in the treatment and management of challenging or complex Ewing Sarcoma Family Tumors. Experts share their knowledge and discuss clinical trials and innovative treatments to help enhance the quality of life for the Ewing Sarcoma patients.

Virtual meetings take place the second Monday of each month at 5 p.m. (EST).

Physicians are invited to participate and submit de-identified cases. Patients and families are not permitted to attend.

Physicians can request an invite to participate by contacting our tumor board coordinator at [email protected]

Physicians can submit cases at clevelandclinic.org/NEWSBoard.

Disclaimer: The National Ewing Sarcoma Tumor Board and its discussions are for educational purposes only. The discussions during the sessions do not represent a second opinion or a formal pathologic, radiographic, surgical or medical review. Each physician presenting on behalf of their patient is solely responsible for their patient’s plan of care.

To request an official pathology second opinion consultation from Cleveland Clinic, please contact your health care provider or visit our web site.

In collaboration with the Carson Sarcoma Foundation, Chemo Warrior Foundation and Allen B. Slifka Foundation.

Cancer Advances Podcast

A Cleveland Clinic podcast for medical professionals exploring the latest innovative research and clinical advances in the field of oncology. Listen to Cancer Advances

Featured Sarcoma Episodes:

Challenges and Opportunities in Pediatric Sarcoma Care

Managing Sarcoma 

Consult QD | Cancer

Our cancer care blog for physicians and healthcare professionals. Discover emerging advances, innovations, and research insights from Cleveland Clinic Cancer Care specialists. Explore Consult QD.