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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Arthritis Surgery
  • Bone Grafting
  • Bone Tumor Surgery
  • Cancer Center
  • Complex Primary Hip Arthroplasty
  • Fracture Care
  • Hip Replacement
  • Hip Surgery
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Knee Reconstructive Surgery
  • Knee Replacement
  • Knee Revision
  • Knee Surgery
  • Musculoskeletal Oncology
  • Orthopaedic Surgery
  • Orthopaedics
  • Primary Total Hip Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery of the Hip
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Arthroplasty
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Sarcoma Oncologists
  • Sarcoma Surgery
  • Second Opinion
  • Soft Tissue Tumor Pathology
  • Soft Tissue Tumor Surgery
  • Surgical Treatment of Arthritis of the Hip
  • Surgical Treatment of Arthritis of the Knee
  • Total Hip Replacement
  • Total Knee Replacement
View all 41 Treatment & Services +

Specialty in Diseases & Conditions

  • Aneurysmal Bone Cyst
  • Arthritis
  • Arthritis of the Hip
  • Arthritis of the Knee
  • Avascular Necrosis
  • Avascular Necrosis of the Hip
  • Avascular Necrosis of the Knee
  • Benign Bone Tumors
  • Bone Cancer
  • Bone Tumors
  • Cancer
  • Epithelioid Hemangioendothelioma (EHE)
  • Giant Cell Tumor of Bone
  • Malignant Peripheral Nerve Sheath Tumors
  • Osteonecrosis
  • Osteosarcoma
  • Pediatric Rare Cancer and Blood Disease Program
  • Pediatric Soft Tissue Sarcoma
  • Pigmented Villonodular Synovitis
  • Rare Cancer and Blood Disease Program
  • Sarcoma
  • Soft Tissue Sarcoma
  • Soft Tissue Tumors
View all 23 Specialties +


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About Nathan Mesko, MD

Nathan W. Mesko, MD is the Section Head of Orthopaedic Oncology and Trauma, and holds his appointment in the Orthopaedic and Rheumatologic Institute at Cleveland Clinic.  In addition, he is co-director of the Sarcoma Center in the Taussig Cancer Institute, and holds an Assistant Professorship at the Cleveland Clinic Lerner College of Medicine

After completing his college education at Wheaton College in Wheaton, Illinois, Dr. Mesko attended Loyola School of Medicine, where he was named to the Alpha Omega Alpha honor society.  He continued his residency training in orthopaedic surgery at Cleveland Clinic, followed by the pursuit of an orthopaedic oncology fellowship at Vanderbilt University (NasHVTIlle, TN).  Here, he received extensive training in benign and malignant bone and soft tissue lesions, metastatic bone and soft tissue cancer, bone and soft tissue sarcoma excision and reconstruction techniques, and complex total hip and total knee primary and revision arthroplasty.  After completing his training in NasHVTIlle, Dr. Mesko was the recipient of the Hatcher Pathology Fellowship from the Musculoskeletal Tumor Society, where he utilized this scholarship to visit various high volume sarcoma centers around the world. These efforts were intended to build further collaboration in the world of clinical and basic science outcome research between sarcoma institutions around the world, as well as to be immersed in various unique technologies.  After returning from England, Dr. Mesko joined the faculty of Cleveland Clinic in 2014.

Dr. Mesko is certified in orthopaedic surgery by the American Board of Orthopaedic Surgery.  He specializes in bone & soft tissue sarcoma diagnosis and treatment. In addition, he also specializes in the treatment of metastatic disease, as well as osteoarthritis and avascular necrosis requiring total joint arthroplasty, including hip resurfacing procedure.  His practice also encompasses total joint revision surgery.

Dr. Mesko’s research interests include clinical outcomes with bone and soft tissue sarcoma treatments, as well as working to improve educational efforts to increase sarcoma awareness.  He is part of a national team that has worked on creating a national sarcoma registry, in an effort to improve functional and cancer outcomes in this rare malignancy.  He has been active in recruiting collaborative projects from around the world to Cleveland Clinic, in an effort to make sure that patients at Cleveland Clinic are part of the latest advances in oncology care effecting the musculoskeletal system.

Outside the hospital, Dr. Mesko and his wife, raise 2 daughters and a Rhodesian ridgeback.  In addition, he enjoys spending time in regions of the world such as Africa and Central America, helping to teach and provide orthopaedic care to areas where appropriate musculoskeletal care is lacking.  Most recently, has enjoyed being a part of Hospital Shalom, a mission hospital in Flores, Guatemala.  He enjoys triathlons, downhill skiing, and water skiing as hobbies.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Vanderbilt University Medical Center
Musculoskeletal Oncology
Nashville, TN

Residency - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH

Medical Education - Loyola University Stritch School of Medicine
Chicago, IL

Undergraduate - Wheaton College
Wheaton, IL


  • Orthopaedic Surgery
Research & Publications

Research & Publications

See publications for Nathan Mesko, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/23/2023, Dr. Mesko has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mesko receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Onkos Surgical, Inc.
  • Stryker Corporation

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

260 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.7
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

36 Patient Comments

Reviewed on May 10, 2024

Dr. Mesko and his nurse arre the verry best. He truly saved my life.

Reviewed on May 3, 2024

Everyone needs a Doctor Mesko

Reviewed on May 1, 2024

This whole practice has been very capable, caring, and well run, really wonderful relative to many other medical experiences

Reviewed on Mar 8, 2024

The Doctor and staff are the best!!!

Reviewed on Feb 20, 2024

Dr Mesko and his staff are the epitome of professionals. The appointment was seamless , and all my questions were answered

Reviewed on Feb 20, 2024

All questions were relevant to my chief complaint. Done in a courteous and professional manner. She answered questions about my concerns, and explained possible treatment plans

Reviewed on Feb 20, 2024

This was a pot-op visit with Dr Mesko. His expertise and professionalism were exceptional!

Reviewed on Feb 13, 2024

We had discussed my treatment plan 3 months ago. I did everything he wanted me to do. I visited another doctor for possible care but eventually turned down a possible experimental surgery from that doctor. That doctor wasn't even sure that surgery would work and the waiting period for tests was taking a very long time and wasn't even addressing my main issue. I believe Dr. Mesko was upset with me this day for cancelling tests with the other doctor. It seemed like my whole treatment going forward is now not being considered high risk as previously.

Reviewed on Feb 9, 2024

Dr. Mesko and his PA, Rachael, are just simply the best. I am grateful for them.

Reviewed on Jan 26, 2024

Dr Mesko is the best!

Reviewed on Jan 23, 2024

Messaging in MyChart works well and the Dr and/or his staff respond in a timely manner.

Reviewed on Jan 23, 2024

Excellent care provided by Dr M.

Reviewed on Jan 23, 2024

Dr. Mesko is first class

Reviewed on Dec 15, 2023

Dr Mesko is an outstanding Doctor.

Reviewed on Dec 15, 2023


Reviewed on Dec 1, 2023

Dr. Masco was very thorough. He took his time talking to me and answered all of my questions. He was very kind and very attentive.

Reviewed on Nov 15, 2023

I am very impressed with Dr Mesko and everyone I have dealt with within his office. It is ram like a fine oiled machine. Extremely efficient.

Reviewed on Nov 3, 2023

The dr. , the assistant And my nurse was very respectful and came me all the answers I needed

Reviewed on Sep 22, 2023

Great appointment with Dr. Mesko and his team. The team is very respectful and invested in my care.

Reviewed on Sep 22, 2023

Dr Mesko - the best!

Reviewed on Sep 15, 2023

What a terrific doctor you have in Dr. Mesco and his team!!

Reviewed on Sep 15, 2023

Dr. Medco is one in 1 million !I never met a doctor, more professional, who genuinely cares about you as a person!His talent as a surgeon is rare, and should be treasured!

Reviewed on Sep 12, 2023

Really like Doctor

Reviewed on Aug 18, 2023

The best doctor and team

Reviewed on Aug 8, 2023

Dr. Mesko is a great surgeon and and also super approachable.

Reviewed on Aug 8, 2023

Awesome doc ! Knowledgeable, curious, thorough.

Reviewed on Aug 2, 2023

Doctor and his staff are super professional and courteous.

Reviewed on Jul 28, 2023

Dr. Mesko and his team are the best that I have ever experienced. I am totally satisfied with the care that I am receiving .

Reviewed on Jul 25, 2023

I have always had wonderful care with Dr. Mesko and his staff.

Reviewed on Jul 19, 2023

Dr Mesko is the best

Reviewed on Jul 7, 2023

Even though he had told me In my chart that he didn't believe my symptoms were related to my hip he was very willing to see me to confirm it. He is a fantastic doctor and person

Reviewed on Jul 5, 2023

Dr. Mesko and his staff are fantastic!

Reviewed on Jul 5, 2023

CCF has always provided great care, service, and ease of access. Dr. Mesko has continued to provide great care in a way that is understandable, professional, personal, and jovial

Reviewed on Jul 5, 2023

Dr. Mesko is great....Personal, professional, and fun

Reviewed on Jun 13, 2023

Dr Mesko & Cassie were very professional & personable. They took the time to address all of my concerns of hip replacement.

Reviewed on Jun 9, 2023

I have always been treated with utmost courtesy, respect and kindness by Dr Mesko, his nurse Rachael, and all his staff

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