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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Locations Specialties & Treatments

Treatment & Services

  • 2nd Opinion Evaluations
  • Arthritis Surgery
  • Arthroplasty
  • Bone Grafting
  • Bone Tumor Surgery
  • Cancer Center
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Hip & Knee Surgery
  • Hip Replacement
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Revision
  • Knee Surgery
  • Musculoskeletal Oncology
  • Orthopaedic Surgery
  • Orthopaedics
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Sarcoma oncologists
  • Sarcoma surgery
  • Second Opinion
  • Soft Tissue (Sarcoma)
  • Soft Tissue Tumor Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
View all 45 Treatment & Services +

Specialty in Diseases & Conditions

  • Aneurysmal Bone Cyst
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Benign Bone Tumors
  • Bone and Soft Tissue Tumors
  • Bone Cancer
  • Bone Tumors
  • Cancer
  • Epithelioid Hemangioendothelioma (EHE)
  • Fractures
  • Giant Cell Tumor of Bone
  • Malignant Bone Tumors.
  • Malignant Peripheral Nerve Sheath Tumors
  • Osteonecrosis
  • Osteosarcoma
  • Pediatric Rare Cancer and Blood Disease Program
  • Pediatric Soft Tissue Sarcoma
  • Pigmented Villonodular Synovitis
  • Rare Cancer and Blood Disease Program
  • Sarcoma
  • Soft Tissue Sarcoma
  • Soft Tissue Tumor Pathology
View all 27 Specialties +


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About Nathan Mesko, MD

Nathan W. Mesko, MD is the Section Head of Orthopaedic Oncology and Trauma, and holds his appointment in the Orthopaedic and Rheumatologic Institute at Cleveland Clinic.  In addition, he is co-director of the Sarcoma Center in the Taussig Cancer Institute, and holds an Assistant Professorship at the Cleveland Clinic Lerner College of Medicine

After completing his college education at Wheaton College in Wheaton, Illinois, Dr. Mesko attended Loyola School of Medicine, where he was named to the Alpha Omega Alpha honor society.  He continued his residency training in orthopaedic surgery at Cleveland Clinic, followed by the pursuit of an orthopaedic oncology fellowship at Vanderbilt University (NasHVTIlle, TN).  Here, he received extensive training in benign and malignant bone and soft tissue lesions, metastatic bone and soft tissue cancer, bone and soft tissue sarcoma excision and reconstruction techniques, and complex total hip and total knee primary and revision arthroplasty.  After completing his training in NasHVTIlle, Dr. Mesko was the recipient of the Hatcher Pathology Fellowship from the Musculoskeletal Tumor Society, where he utilized this scholarship to visit various high volume sarcoma centers around the world. These efforts were intended to build further collaboration in the world of clinical and basic science outcome research between sarcoma institutions around the world, as well as to be immersed in various unique technologies.  After returning from England, Dr. Mesko joined the faculty of Cleveland Clinic in 2014.

Dr. Mesko is certified in orthopaedic surgery by the American Board of Orthopaedic Surgery.  He specializes in bone & soft tissue sarcoma diagnosis and treatment. In addition, he also specializes in the treatment of metastatic disease, as well as osteoarthritis and avascular necrosis requiring total joint arthroplasty, including hip resurfacing procedure.  His practice also encompasses total joint revision surgery.

Dr. Mesko’s research interests include clinical outcomes with bone and soft tissue sarcoma treatments, as well as working to improve educational efforts to increase sarcoma awareness.  He is part of a national team that has worked on creating a national sarcoma registry, in an effort to improve functional and cancer outcomes in this rare malignancy.  He has been active in recruiting collaborative projects from around the world to Cleveland Clinic, in an effort to make sure that patients at Cleveland Clinic are part of the latest advances in oncology care effecting the musculoskeletal system.

Outside the hospital, Dr. Mesko and his wife, raise 2 daughters and a Rhodesian ridgeback.  In addition, he enjoys spending time in regions of the world such as Africa and Central America, helping to teach and provide orthopaedic care to areas where appropriate musculoskeletal care is lacking.  Most recently, has enjoyed being a part of Hospital Shalom, a mission hospital in Flores, Guatemala.  He enjoys triathlons, downhill skiing, and water skiing as hobbies.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Vanderbilt University Medical Center
Musculoskeletal Oncology
Nashville, TN USA

Residency - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH USA

Medical Education - Loyola University Stritch School of Medicine
Chicago, IL USA

Undergraduate - Wheaton College
Wheaton, IL USA


  • Orthopaedic Surgery
Research & Publications

Research & Publications

See publications for Nathan Mesko, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/3/2022, Dr. Mesko has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mesko receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Onkos Surgical, Inc.
  • Stryker Corporation

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

219 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.8
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

39 Patient Comments

Reviewed on Apr 19, 2023

I highly recommend Dr. Mesko & his team to anyone who is considering a joint replacement.

Reviewed on Apr 4, 2023

Confident, professionally nice, waited the longest to see him and left there feeling uneasy

Reviewed on Mar 31, 2023

*Dr. Raymond and his entire staff really listened to me and herd my concerns and treated me with dignity and respect and care.

Reviewed on Mar 31, 2023

Dr. Nathan Mesko and his staff are experienced and compassionate professionals who provide expert and quality medical care. I am very greatful for the care I receive from them at the Cleveland Clinic.

Reviewed on Mar 31, 2023

Dr. Mesko is very thorough. I would definitely recommend him.

Reviewed on Mar 21, 2023

Sue that is Doctor Meskos assistant was very helpful and polite

Reviewed on Mar 17, 2023

It was a pleasure seeing Dr. Mesko and his staff!

Reviewed on Mar 17, 2023

I felt very well taken care of by Dr. Mesko, his nurse, his PA and the check in person!

Reviewed on Mar 14, 2023

Dr Mesko in Orthopedics is FANTASTIC and so is his female PA!!!!!! Absolutely FANTASTIC!! Give them a raise so that they don't leave! Dr. Mesko learned under the retired Dr. Michael Joyce who was also VERY FANTASTIC!!!!!!

Reviewed on Mar 14, 2023

Dr Mesko provided, outstanding care, compassion, honesty, and I like that he actually shakes my hand. As well, he listens to what I have to say.

Reviewed on Mar 14, 2023

Dr Mesko's entire team- PA, nurses and others attending to my care around my "special case' situation always feel like they have my best interest in mind. The only real delay I had was with the Dynasplint rep and that's outside of the clinic's control.

Reviewed on Mar 14, 2023

I appreciate the time Dr. Mesko and Cassandra took to listen to my concerns and the series of appointments I had prior to this one. Dr. Mesko shared clear explanations and outlined a plan for further investigation and treatment based on not only the medical issue, but my preference.

Reviewed on Mar 3, 2023

Recommend people to Dr. Mesko every chance I get.

Reviewed on Feb 17, 2023

Dr Mesko always takes him time with me, explains things and makes me feel like he truly cares. He is an incredible doctor and human being.

Reviewed on Feb 17, 2023

Dr. Mesko and Rachael have been patient and very kind in our encounters. He has been forthright and considerate when delivering very distressing outcomes from tests and in providing a plan of care.

Reviewed on Feb 15, 2023

Dr. Mesko is a brilliant surgeon, and he is also a caring person who listens and responds to all my concerns.

Reviewed on Feb 14, 2023

Dr Mesko and his staff are amazing!

Reviewed on Jan 25, 2023

Felt that the Nurse Practioner and the doctor actually cared about my problem, my pain, and my input.

Reviewed on Jan 20, 2023

Dr. Mesco is an excellent orthopedic surgeon, he takes his time listening and explaining.

Reviewed on Dec 27, 2022

Been referring Dr. Mesko to other patients looking for help with knees and hips

Reviewed on Dec 21, 2022

Dr.Mesko and his assistant listened and addressed my concerns about my knee replacement. Prompt about getting information to me in an expedient manner via phone, email, mail

Reviewed on Dec 21, 2022

I wish every doctor had brilliance and compassion like Dr. Mesko.

Reviewed on Dec 21, 2022

Dr Mesko saved my life in 2016 . I am blessed and grateful to have a doctor who Is kind and brilliant. God Bless Dr Mesko and staff

Reviewed on Dec 15, 2022

Dr. Mesko has been the best doctor overall I've ever worked with

Reviewed on Nov 8, 2022

Dr. Mesko is always so easy to talk to, answer questions. So happy to have him as my surgeon.

Reviewed on Nov 4, 2022

My level of respect increases to the degree my doctor listens to me and acknowledges my perspective.

Reviewed on Nov 4, 2022

The responsiveness of Dr. Mesko's entire staff is most impressive to me. My concerns or issues were promptly addressed each time I needed assistance. Since my location is not in Ohio, this was important to me.

Reviewed on Nov 1, 2022

Dr. Mesko has always been very respectful and informative about my procedures

Reviewed on Oct 25, 2022

Dr. Mesco did an excellent job. I'm very thankful that I had him as my doctor

Reviewed on Sep 28, 2022

Dr Mesko is the best!! I wouldn't go anywhere else

Reviewed on Sep 6, 2022

The doctor, his nurse and staff were extraordinary in their expertise and attentiveness to my questions and concerns.

Reviewed on Sep 6, 2022

I have already recommended this doctor and the Cleveland Clinic to others experiencing my same health condition.

Reviewed on Jul 29, 2022

Dr Mesko is amazing and I am very fortunate to have found him.

Reviewed on Jul 29, 2022

Dr Mesko is always kind and compassionate and answers all of our questions.

Reviewed on Jul 26, 2022

Great experience. Dr. Mesko, and his staff explained everything to me, and answered all my questions. When I emailed them post surgery, I received an answer promptly.

Reviewed on Jul 20, 2022

I was very favorably impressed with my entire experience at Cleveland Clinic. Doctor Mesko is great.

Reviewed on Jul 19, 2022

Dr. Mesko and his staff best group I've had with an illness

Reviewed on May 20, 2022

Dr Mesko is very professional and was the best. I would recommend him for surgery to anyone. Loved his bed side manner and informed me to what was happening and doing. I'll call him for my next surgery if I need any done.

Reviewed on May 17, 2022

Dr. Mesko, his Residents, and his nurse were all excellent!

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