Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • 2nd Opinion Evaluations
  • Arthritis Surgery
  • Arthroplasty
  • Bone Grafting
  • Bone Tumor Surgery
  • Cancer
  • Cancer Center
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Hip & Knee Surgery
  • Hip Replacement
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Revision
  • Knee Surgery
  • Musculoskeletal Oncology
  • Orthopaedic Surgery
  • Orthopaedics
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Second Opinion
  • Soft Tissue (Sarcoma)
  • Soft Tissue Tumor Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
View all 44 Treatment & Services +

Specialty in Diseases & Conditions

  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Benign Bone Tumors
  • Bone and Soft Tissue Tumors
  • Bone Cancer
  • Bone Tumors
  • Epithelioid Hemangioendothelioma (EHE)
  • Hip Replacement
  • Malignant Bone Tumors.
  • Osteonecrosis
  • Osteosarcoma
  • Pediatric Soft Tissue Sarcoma
  • Rare Cancer and Blood Disease Program
  • Sarcoma
  • Soft Tissue Sarcoma
  • Soft Tissue Tumor Pathology
View all 21 Specialties +


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About Nathan Mesko, MD

Nathan W. Mesko, MD is the Section Head of Orthopaedic Oncology and Trauma, and holds his appointment in the Orthopaedic and Rheumatologic Institute at Cleveland Clinic.  In addition, he is co-director of the Sarcoma Center in the Taussig Cancer Institute, and holds an Assistant Professorship at the Cleveland Clinic Lerner College of Medicine

After completing his college education at Wheaton College in Wheaton, Illinois, Dr. Mesko attended Loyola School of Medicine, where he was named to the Alpha Omega Alpha honor society.  He continued his residency training in orthopaedic surgery at Cleveland Clinic, followed by the pursuit of an orthopaedic oncology fellowship at Vanderbilt University (Nashville, TN).  Here, he received extensive training in benign and malignant bone and soft tissue lesions, metastatic bone and soft tissue cancer, bone and soft tissue sarcoma excision and reconstruction techniques, and complex total hip and total knee primary and revision arthroplasty.  After completing his training in Nashville, Dr. Mesko was the recipient of the Hatcher Pathology Fellowship from the Musculoskeletal Tumor Society, where he utilized this scholarship to visit various high volume sarcoma centers around the world. These efforts were intended to build further collaboration in the world of clinical and basic science outcome research between sarcoma institutions around the world, as well as to be immersed in various unique technologies.  After returning from England, Dr. Mesko joined the faculty of Cleveland Clinic in 2014.

Dr. Mesko is certified in orthopaedic surgery by the American Board of Orthopaedic Surgery.  He specializes in bone & soft tissue sarcoma diagnosis and treatment. In addition, he also specializes in the treatment of metastatic disease, as well as osteoarthritis and avascular necrosis requiring total joint arthroplasty, including hip resurfacing procedure.  His practice also encompasses total joint revision surgery.

Dr. Mesko’s research interests include clinical outcomes with bone and soft tissue sarcoma treatments, as well as working to improve educational efforts to increase sarcoma awareness.  He is part of a national team that has worked on creating a national sarcoma registry, in an effort to improve functional and cancer outcomes in this rare malignancy.  He has been active in recruiting collaborative projects from around the world to Cleveland Clinic, in an effort to make sure that patients at Cleveland Clinic are part of the latest advances in oncology care effecting the musculoskeletal system.

Outside the hospital, Dr. Mesko and his wife, raise 2 daughters and a Rhodesian ridgeback.  In addition, he enjoys spending time in regions of the world such as Africa and Central America, helping to teach and provide orthopaedic care to areas where appropriate musculoskeletal care is lacking.  Most recently, has enjoyed being a part of Hospital Shalom, a mission hospital in Flores, Guatemala.  He enjoys triathlons, downhill skiing, and water skiing as hobbies.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Vanderbilt University Medical Center
Musculoskeletal Oncology
Nashville, TN USA

Residency - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH USA

Medical School - Loyola University Stritch School of Medicine
Chicago, IL USA

Undergraduate - Wheaton College
Wheaton, IL USA


  • Orthopaedic Surgery
Research & Publications

Research & Publications

See publications for Nathan Mesko, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/29/2018, Dr. Mesko has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mesko receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Synthes

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

309 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.9
Courtesy, Respect & Concern 4.9
Knows Medical History 4.8
Time Spent with Patient 4.9
Patient Rating of Doctor 4.9

41 Patient Comments

Reviewed on Mar 26, 2019

appointments scheduled at 10:15 did not see Dr. Mesko until 11:00 . Dr. Mesko is always couteoius, professional , and friendly. Very pleased with the time that he spent answering all of my questions.

Reviewed on Mar 20, 2019

The PA was so wonderful and helpful. As for Dr Mesko - I cannot thank him enough for the help and care that he provided me. Dr Mesko has given back a quality of life that I have not had for over 4 years. He and his team are amazing.

Reviewed on Mar 20, 2019

Love Dr. Mesko and his team. Professional and prompt with any of my questions or concerns.

Reviewed on Mar 20, 2019

Dr Mesko is very thorough in everything. Excellent

Reviewed on Mar 19, 2019

Dr. Mesko is great about replying to questions on mychart messaging in a relatively quick manner.

Reviewed on Mar 7, 2019

*Dr. Mesko is outstanding surgeon - Skilled and caring & an excellent communicator.

Reviewed on Mar 6, 2019

Explained everything & I felt I picked the best dr. I could have.

Reviewed on Feb 22, 2019

The doctor spent a lot of time with me explaining the situation and what they need to do to fix it there was a lot of one on one time it wasn't just get in and get out

Reviewed on Feb 12, 2019

dr. Mesko was wonderful. went above and beyond for me with 2 others issues I was having not related to my cancer appt

Reviewed on Jan 2, 2019

Our family is so thankful for Dr. Mesko and the care he has provided for our son. Dr. Mesko and his staff have been so positive and understanding with our teenage son and our whole family will always appreciate that.

Reviewed on Dec 26, 2018

Dr, Mesko is a very caring Doctor. He listens to the patient and lets them know the next steps that he plans on doing. Very good Doctor who is an asset to the Cleveland Clinic

Reviewed on Dec 5, 2018

I am not very good about seeing doctors or having procedures completed. Dr. Mesko is always concerned about my comfort and helping me deal with my fears. Dr. Mesko is the best surgeon / physician I have ever had!

Reviewed on Dec 5, 2018

very good appointment. I appreciate Dr. Mesko's knowledge and his bedside manner in answering questions. My wife was also pleased with his communication skills in answering all questions.

Reviewed on Nov 9, 2018

I definitely would recommend Dr. Mesko, he took the time to listen to my concerns, followed through with what he said he needed to research In a prompt fashion. He has compassion and genuinely cares. I like being able to communicate through email. Thank you for your great care.

Reviewed on Nov 7, 2018

Dr. Mesko is the most considerate doctor that I've ever met. He is an expert in his field, but still takes time to listen to the patient.

Reviewed on Nov 2, 2018

Good experience with Dr Nathan Mesko. Some time needed for wt.loss before hip replacement.Told him l'd see him very soon. lmpressed with his bio & Credentials.

Reviewed on Oct 3, 2018

absolutely love Dr. Mesko

Reviewed on Sep 29, 2018

*Dr. Mesko - very compassionate and caring.

Reviewed on Aug 31, 2018

Dr Mesko is supportive and familiar with my health situation

Reviewed on Aug 29, 2018

Physician was addressing another medical issue and was I informed by staff of the delay. Had absolutely no problem with waiting since the physician was addressing a medical issue. Physician apologized for making us wait which was I appreciated but was in no way upset with having to wait.

Reviewed on Aug 29, 2018

always happy to see Dr. Mesko and Rachel

Reviewed on Aug 29, 2018

Dr Mesko is a very caring Doctor.

Reviewed on Aug 29, 2018

Dr. Mesko knows I am high risk and he makes sure that he covers everything at my follow up appointment

Reviewed on Aug 29, 2018

Dr. Mesko always makes time to see me for he knows I have a very serious health problem.

Reviewed on Aug 28, 2018

Dr and Staff provided great service.

Reviewed on Aug 28, 2018

aappt arrival, waiting room and being seen by nurse then doctor seemed flawless.

Reviewed on Aug 22, 2018

we could not have been happier or more relieved when we left his office dr. Mesko and his assistant were fantastic. for the first time in 8 years a weight has been lifted off me.

Reviewed on Aug 22, 2018

we had to wait a while but that was okay I wasn't really upset about that just how rude I knew dr. Mesko would give us the same care but everybody else got so I was willing to wait with no problem. and dr. Mesko was fantastic I couldn't could not have asked for a better doctor to have stayed down there he represents the clinic very well you should be very proud of him.

Reviewed on Aug 10, 2018

I was very comfortable in discussing my problems and Dr Berger also included my family that was with me in our conversations.

Reviewed on Aug 10, 2018

recommend this provider

Reviewed on Jul 24, 2018

Dr. Mesko showed great kindness and knowledge during my appointment. I am grateful that he saw me.

Reviewed on Jul 18, 2018

We are from out of state (ILL). we went to Cleveland Clinic where Dr. Mesko performed surgery on my wife. When he came in to visit her the next morning, I explained to him that I had. bad knee, would like to have it ltaken care of while my wife was recovering. Dr. Mesko contacted his Nurse and scheduled an appointment for the next day. My whole family was very impressed with Dr. Mesko and his ability to perform a surgery that we were not able to get at other major hospitals. We are very thankful for Dr Mesko and his staff.

Reviewed on Jul 18, 2018

I was shown the type of knee replacement, recovery time, and an examination of the knee.. This was probably the best visit I have had at a doctors office.

Reviewed on Jul 13, 2018

Wonderful experience. I would recommend Dr. Mesko to anyone.

Reviewed on Jun 29, 2018

I came in from PA and got there at 11:30. We ate at Carve (fabulous place). My xray appointment was at 12:20 and I got in right away. My appt with Dr. Mesko was at 1:30. I got in about 2:00. I must say waiting was not a negative experience. The waiting area is pleasant, not crowded, and there was a TV to watch.

Reviewed on Jun 13, 2018

Our son is dealing with a health issue that is extremely scary for all of us. We were so impressed with Dr. Mesko's ability to communicate to us what we are dealing with and do it in a manner that gave us hope. We are so thankful to have Dr. Mesko as our child's doctor at this time.

Reviewed on Jun 8, 2018

I waited 45 minutes for the physician to come into my room.

Reviewed on Jun 8, 2018

Having Dr MESKO work with me has Been an excellent experience. He is efficient, thorough, and direct about the process and desired outcome of procedure recomended!

Reviewed on May 30, 2018

Got in right away to see the Dr., didn't have to wait very long. He explains everything to me.

Reviewed on May 30, 2018

Dr. Mesko listen's to me and always ask if I have any other questions.

Reviewed on May 16, 2018

The office staff has always been courteous to me. When I have an appointment I do not wait sometimes I even get to go in early. I cannot speak enough of dr. Mesko and his nurse Rachel. Dr. Mesko did surgery on me and I couldn't have asked for a better provider I think he helped save me. Whenever I come to the office Rachel's just wonderful she is helped me she answers my questions if I call. Just A1 staff

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