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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • 2nd Opinion Evaluations
  • Arthritis Surgery
  • Arthroplasty
  • Bone Grafting
  • Bone Tumor Surgery
  • Cancer
  • Cancer Center
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Hip & Knee Surgery
  • Hip Replacement
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Revision
  • Knee Surgery
  • Musculoskeletal Oncology
  • Orthopaedic Surgery
  • Orthopaedics
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Sarcoma oncologists
  • Sarcoma surgery
  • Second Opinion
  • Soft Tissue (Sarcoma)
  • Soft Tissue Tumor Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
View all 46 Treatment & Services +

Specialty in Diseases & Conditions

  • Aneurysmal Bone Cyst
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Benign Bone Tumors
  • Bone and Soft Tissue Tumors
  • Bone Cancer
  • Bone Tumors
  • Epithelioid Hemangioendothelioma (EHE)
  • Giant Cell Tumor of Bone
  • Hip Replacement
  • Malignant Bone Tumors.
  • Malignant Peripheral Nerve Sheath Tumors
  • Osteonecrosis
  • Osteosarcoma
  • Pediatric Rare Cancer and Blood Disease Program
  • Pediatric Soft Tissue Sarcoma
  • Pigmented Villonodular Synovitis
  • Rare Cancer and Blood Disease Program
  • Sarcoma
  • Soft Tissue Sarcoma
  • Soft Tissue Tumor Pathology
View all 26 Specialties +


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About Nathan Mesko, MD

Nathan W. Mesko, MD is the Section Head of Orthopaedic Oncology and Trauma, and holds his appointment in the Orthopaedic and Rheumatologic Institute at Cleveland Clinic.  In addition, he is co-director of the Sarcoma Center in the Taussig Cancer Institute, and holds an Assistant Professorship at the Cleveland Clinic Lerner College of Medicine

After completing his college education at Wheaton College in Wheaton, Illinois, Dr. Mesko attended Loyola School of Medicine, where he was named to the Alpha Omega Alpha honor society.  He continued his residency training in orthopaedic surgery at Cleveland Clinic, followed by the pursuit of an orthopaedic oncology fellowship at Vanderbilt University (NasHVTIlle, TN).  Here, he received extensive training in benign and malignant bone and soft tissue lesions, metastatic bone and soft tissue cancer, bone and soft tissue sarcoma excision and reconstruction techniques, and complex total hip and total knee primary and revision arthroplasty.  After completing his training in NasHVTIlle, Dr. Mesko was the recipient of the Hatcher Pathology Fellowship from the Musculoskeletal Tumor Society, where he utilized this scholarship to visit various high volume sarcoma centers around the world. These efforts were intended to build further collaboration in the world of clinical and basic science outcome research between sarcoma institutions around the world, as well as to be immersed in various unique technologies.  After returning from England, Dr. Mesko joined the faculty of Cleveland Clinic in 2014.

Dr. Mesko is certified in orthopaedic surgery by the American Board of Orthopaedic Surgery.  He specializes in bone & soft tissue sarcoma diagnosis and treatment. In addition, he also specializes in the treatment of metastatic disease, as well as osteoarthritis and avascular necrosis requiring total joint arthroplasty, including hip resurfacing procedure.  His practice also encompasses total joint revision surgery.

Dr. Mesko’s research interests include clinical outcomes with bone and soft tissue sarcoma treatments, as well as working to improve educational efforts to increase sarcoma awareness.  He is part of a national team that has worked on creating a national sarcoma registry, in an effort to improve functional and cancer outcomes in this rare malignancy.  He has been active in recruiting collaborative projects from around the world to Cleveland Clinic, in an effort to make sure that patients at Cleveland Clinic are part of the latest advances in oncology care effecting the musculoskeletal system.

Outside the hospital, Dr. Mesko and his wife, raise 2 daughters and a Rhodesian ridgeback.  In addition, he enjoys spending time in regions of the world such as Africa and Central America, helping to teach and provide orthopaedic care to areas where appropriate musculoskeletal care is lacking.  Most recently, has enjoyed being a part of Hospital Shalom, a mission hospital in Flores, Guatemala.  He enjoys triathlons, downhill skiing, and water skiing as hobbies.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Vanderbilt University Medical Center
Musculoskeletal Oncology
Nashville, TN USA

Residency - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH USA

Medical Education - Loyola University Stritch School of Medicine
Chicago, IL USA

Undergraduate - Wheaton College
Wheaton, IL USA


  • Orthopaedic Surgery
Research & Publications

Research & Publications

See publications for Nathan Mesko, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/22/2021, Dr. Mesko has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mesko receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Stryker Corporation
  • Onkos Surgical, Inc.
  • BoneSupport AB

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

218 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.8
Courtesy, Respect & Concern 4.9
Time Spent with Patient 5
Patient Rating of Doctor 4.9

43 Patient Comments

Reviewed on Jun 9, 2021

Dr. Memo is an outstanding doctor.....

Reviewed on May 26, 2021

Dr Mesko did well considering the technology was not working

Reviewed on May 19, 2021

Dr. Mesko has been very caring.

Reviewed on May 7, 2021

Dr Mesko was very patient and always takes appropriate time with me. I am impressed with his knowledge and he explains everything very well.

Reviewed on May 7, 2021

Rachael at Dr. Mesko's office took care of everything.

Reviewed on May 7, 2021

Always the best. Dr. Mesko and his team are top shelf! I highly recommend him

Reviewed on May 7, 2021

Always the best. Dr. Mesko and his team are top shelf! I highly recommend him. I don't trust anyone else with my orthopaedic health needs.

Reviewed on May 5, 2021

A wonderful doctor at Cleveland Clinic.This will be my second procedure with him. I trust his judgement and expertise.

Reviewed on Apr 30, 2021

Rachel, Dr. Mesko's nurse scheduled my appointment. She is the best.

Reviewed on Apr 30, 2021

Dr Mesko is a great doctor and I would highly recommend him.

Reviewed on Apr 28, 2021

Dr Mesko is always direct, polite, focused, informed, motivated, and efficient

Reviewed on Mar 31, 2021

I recommended Dr Mesko to a female below the knee amputee, who cannot use her prosthetic because of pain, who made her appt and has already seen Dr Mesko in less than 3 weeks.

Reviewed on Mar 24, 2021

excellent MD and residents!!!! highly recommend them for Pt in need

Reviewed on Mar 19, 2021

Dr. Mesko and Andre are the best! My wife and I were extremely happy with their care. We will recommend them to anyone we know who needs a knee replacement.

Reviewed on Mar 19, 2021

Dr Mesko was very personable and to the point during my visit.

Reviewed on Mar 11, 2021

*Dr. Nathan Mesko is a wonderful doctor who gives me great care and spends time up and over what one would normally expect from a doctor.

Reviewed on Feb 24, 2021

Dr. Mesko is professional, thorough, kind and he listens to my concerns. He takes time to explain everything and makes me feel like my health is important to him. He is an incredibly caring doctor.

Reviewed on Feb 17, 2021

i felt heard. Rachael and Dr. Mesko both top notch.

Reviewed on Feb 12, 2021

Dr. Mesko is the best Doctor I have ever had in my life. I am very happy with the outcome of my surgery.

Reviewed on Feb 5, 2021

very good first time experience with dr Mesko. very thorough and caring

Reviewed on Jan 15, 2021

Dr Mesko is simply amazing. He saved my life. Thank you

Reviewed on Jan 6, 2021

*Dr. Mesko was highly recommended by *Dr. Joyce, the surgeon who performed a successful resection of the sarcoma in my leg - and *Dr. Joyce was right! *Dr. Mesko is very attentive, professional, and willing to explain.

Reviewed on Dec 22, 2020

Doc was very helpful

Reviewed on Dec 9, 2020

Dr. Mesko has such integrity that is obvious in all that he does. He is just naturally able to relate and put himself in the place of the patient-listening, feeling what they do. He is the real deal, what you get is him, at 100% himself. not a doctor in a hurry, or trying to guard his "numbers" . Don't ever let him get away with all the stress that is put on CC doctors to to more more more with less. Dr. Mesko could be a role model to so many in speciality and primary care!

Reviewed on Dec 4, 2020

Excellent physician care - saw several teams.

Reviewed on Nov 25, 2020

I have been extremely satisfied with the care Dr. Mesko has provided me. I drive 5 hours to see him and it is well worth it.

Reviewed on Nov 20, 2020

Dr. Mesko, Rachel, and a resident (I forget his name!) did a thorough exam on my knee, showed and explained my X-rays to me, and answered all my questions...Then Dr. Mesko gave me options for treatment of my knee now and in the future!! They took their time and I did not feel "rushed"...I HIGHLY recommend Dr. Mesko and his staff!!

Reviewed on Nov 20, 2020

Dr. Mesko is the best...seriously!!

Reviewed on Nov 20, 2020

We definitely recommend Dr. Mesko!! and of course The Cleveland Clinic is the BEST hospital!! We are blessed to live only an hour away from the Cleveland Clinic!!

Reviewed on Nov 13, 2020

Dr Mesco is a great listener, very caring and easy to talk to!

Reviewed on Nov 6, 2020

Very clear, helpful. and went the extra mile by emailing Dr. Joyce (who I had seen previously) to give him an update.

Reviewed on Oct 28, 2020

Dr Mesko was very clear about this checkup for my knee replacements, showed me all the xrays on the screen. He had ordered them at the closest hospital imaging center to me and I mailed the disc of images to him. I was able to show him how my incisions look now and that I can fully straighten and bend them. I love the safety and lowered risk of using the video visits for this type of appointment so I don't need to travel the 180 mile round trip for stuff that can be hands off.

Reviewed on Oct 28, 2020

Dr Mesko was very attentive and thorough!!

Reviewed on Oct 23, 2020

I really appreciate how even doctor on the team, seemed to be informed about my total care.

Reviewed on Sep 29, 2020

Dr. Mesko is the best.

Reviewed on Sep 18, 2020

Doctor Mesko really cares about me and my concerns. He is the best.

Reviewed on Sep 18, 2020

Dr. Mesko & his staff are awesome!

Reviewed on Sep 16, 2020

*Dr. Mesko, saved my life, as well as his team. *Dr. Babic entertained all my concerns and suggestions.

Reviewed on Sep 9, 2020

Dr. Mesko has always gone above and beyond for my care. Thank you!

Reviewed on Sep 2, 2020

Received outstanding care from *Dr. Meslo, so pleased I chose him as my surgeon.

Reviewed on Aug 26, 2020

Greatly appreciate Dr. Nathan Mesko and his team. Highly recommend Dr. Nathan Mesko for his compassion and expertise.

Reviewed on Aug 19, 2020

polite staff and doctor made me feel comfortable and relaxed

Reviewed on Aug 19, 2020

Dr Mesko is by far the absolute BEST doctor. He and his team are amazing. I am forever truly grateful for him and Cleveland Clinic.

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