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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • 2nd Opinion Evaluations
  • Arthritis Surgery
  • Arthroplasty
  • Bone Grafting
  • Bone Tumor Surgery
  • Cancer
  • Cancer Center
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Hip & Knee Surgery
  • Hip Replacement
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Revision
  • Knee Surgery
  • Musculoskeletal Oncology
  • Orthopaedic Surgery
  • Orthopaedics
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Sarcoma oncologists
  • Sarcoma surgery
  • Second Opinion
  • Soft Tissue (Sarcoma)
  • Soft Tissue Tumor Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
View all 46 Treatment & Services +

Specialty in Diseases & Conditions

  • Aneurysmal Bone Cyst
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Benign Bone Tumors
  • Bone and Soft Tissue Tumors
  • Bone Cancer
  • Bone Tumors
  • Epithelioid Hemangioendothelioma (EHE)
  • Fractures
  • Giant Cell Tumor of Bone
  • Hip Replacement
  • Malignant Bone Tumors.
  • Malignant Peripheral Nerve Sheath Tumors
  • Osteonecrosis
  • Osteosarcoma
  • Pediatric Rare Cancer and Blood Disease Program
  • Pediatric Soft Tissue Sarcoma
  • Pigmented Villonodular Synovitis
  • Rare Cancer and Blood Disease Program
  • Sarcoma
  • Soft Tissue Sarcoma
  • Soft Tissue Tumor Pathology
View all 27 Specialties +


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About Nathan Mesko, MD

Nathan W. Mesko, MD is the Section Head of Orthopaedic Oncology and Trauma, and holds his appointment in the Orthopaedic and Rheumatologic Institute at Cleveland Clinic.  In addition, he is co-director of the Sarcoma Center in the Taussig Cancer Institute, and holds an Assistant Professorship at the Cleveland Clinic Lerner College of Medicine

After completing his college education at Wheaton College in Wheaton, Illinois, Dr. Mesko attended Loyola School of Medicine, where he was named to the Alpha Omega Alpha honor society.  He continued his residency training in orthopaedic surgery at Cleveland Clinic, followed by the pursuit of an orthopaedic oncology fellowship at Vanderbilt University (NasHVTIlle, TN).  Here, he received extensive training in benign and malignant bone and soft tissue lesions, metastatic bone and soft tissue cancer, bone and soft tissue sarcoma excision and reconstruction techniques, and complex total hip and total knee primary and revision arthroplasty.  After completing his training in NasHVTIlle, Dr. Mesko was the recipient of the Hatcher Pathology Fellowship from the Musculoskeletal Tumor Society, where he utilized this scholarship to visit various high volume sarcoma centers around the world. These efforts were intended to build further collaboration in the world of clinical and basic science outcome research between sarcoma institutions around the world, as well as to be immersed in various unique technologies.  After returning from England, Dr. Mesko joined the faculty of Cleveland Clinic in 2014.

Dr. Mesko is certified in orthopaedic surgery by the American Board of Orthopaedic Surgery.  He specializes in bone & soft tissue sarcoma diagnosis and treatment. In addition, he also specializes in the treatment of metastatic disease, as well as osteoarthritis and avascular necrosis requiring total joint arthroplasty, including hip resurfacing procedure.  His practice also encompasses total joint revision surgery.

Dr. Mesko’s research interests include clinical outcomes with bone and soft tissue sarcoma treatments, as well as working to improve educational efforts to increase sarcoma awareness.  He is part of a national team that has worked on creating a national sarcoma registry, in an effort to improve functional and cancer outcomes in this rare malignancy.  He has been active in recruiting collaborative projects from around the world to Cleveland Clinic, in an effort to make sure that patients at Cleveland Clinic are part of the latest advances in oncology care effecting the musculoskeletal system.

Outside the hospital, Dr. Mesko and his wife, raise 2 daughters and a Rhodesian ridgeback.  In addition, he enjoys spending time in regions of the world such as Africa and Central America, helping to teach and provide orthopaedic care to areas where appropriate musculoskeletal care is lacking.  Most recently, has enjoyed being a part of Hospital Shalom, a mission hospital in Flores, Guatemala.  He enjoys triathlons, downhill skiing, and water skiing as hobbies.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Vanderbilt University Medical Center
Musculoskeletal Oncology
Nashville, TN USA

Residency - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH USA

Medical Education - Loyola University Stritch School of Medicine
Chicago, IL USA

Undergraduate - Wheaton College
Wheaton, IL USA


  • Orthopaedic Surgery
Research & Publications

Research & Publications

See publications for Nathan Mesko, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/3/2022, Dr. Mesko has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mesko receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Stryker Corporation
  • Onkos Surgical, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

189 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Listens 4.5
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.9

40 Patient Comments

Reviewed on Jul 29, 2022

Dr Mesko is amazing and I am very fortunate to have found him.

Reviewed on Jul 29, 2022

Dr Mesko is always kind and compassionate and answers all of our questions.

Reviewed on Jul 26, 2022

Great experience. Dr. Mesko, and his staff explained everything to me, and answered all my questions. When I emailed them post surgery, I received an answer promptly.

Reviewed on Jul 20, 2022

I was very favorably impressed with my entire experience at Cleveland Clinic. Doctor Mesko is great.

Reviewed on Jul 19, 2022

Dr. Mesko and his staff best group I've had with an illness

Reviewed on May 20, 2022

Dr Mesko is very professional and was the best. I would recommend him for surgery to anyone. Loved his bed side manner and informed me to what was happening and doing. I'll call him for my next surgery if I need any done.

Reviewed on May 17, 2022

Dr. Mesko, his Residents, and his nurse were all excellent!

Reviewed on May 6, 2022

Saw Dr Mesko med student first then Dr Mesko Both about equal in time no complaints

Reviewed on May 5, 2022

*Dr. Mesko and his residents were excellent! My hospitalist, *Dr. Mayock was outstanding!

Reviewed on Apr 26, 2022

Every follow up visit to Dr Mesko was very detailed responses, he is an excellent surgeon!

Reviewed on Mar 18, 2022

Dr Mesko and his associate treated me very well.

Reviewed on Mar 1, 2022

Dr. Mesko diagnosed and fixed a problem that others had failed to correctly identify. I am moving better than any time in the last three years and am pain free. He is an excellent doctor. Also thanks to my main Dr. Cartabuke for the recommendation.

Reviewed on Jan 11, 2022

Dr. Mesko is the best. Excellent care is always provided.

Reviewed on Dec 29, 2021

Dr. Mesko is thorough, and clear on his description of my issues and very comprehensive is his overview of options and items that would be beneficial for my reason for seeing him.

Reviewed on Dec 22, 2021

Dr Mesko and his team are professionals and extremely caring

Reviewed on Dec 22, 2021

Dr Mesko is excellent

Reviewed on Dec 15, 2021

Dr. Mesko is an exceptionally at expaining issues

Reviewed on Dec 14, 2021

Dr. Mesco did an excellent job on my knee. I would highly recommend him for this type of surgery. Physical Therapy was also excellent.

Reviewed on Dec 14, 2021

Dr. Mesko does a good job of explaining options, answering questions, etc.

Reviewed on Dec 14, 2021

Dr. Mesko is very involved and interested in all our concerns. He's thoughtful, will take time with you, but doesn't waste time talking about other things

Reviewed on Dec 3, 2021

From the moment I walked into his office area, I was met with total an complete professionalism with every employee that I encountered. As I have been having pain for 8 months with no relief from the doctors at lorain Cleveland clinic, I had heard and could feel that I had finally come to the right doctor.

Reviewed on Dec 3, 2021

When dr.mesko walked into the room and started discussing my medical problem, I knew he had read the mri's , knew what was wrong and had a plan to get me back to medical health and back to my life prior to this problem. I felt a relief that I had finally come to the right doctor. I am a 75 year old woman who takes care of her yard.2, has a riding mower, you cannot imagine my total relief.saw and everything it takes to maintain it. I also use a chainsaw that I bought for my 70th birthday.

Reviewed on Dec 3, 2021

Dr.mesko and his staff are the type of employees that make Cleveland clinic worth bragging about.

Reviewed on Dec 1, 2021

Much respect and appreciation for Dr Mesko, he's been there for me on several occasions and will never hesitate to see him ( or refer him) for my orthopedic needs

Reviewed on Dec 1, 2021

Excellent physician. Very courteous, kind and professional. I really appreciate his expertise

Reviewed on Dec 1, 2021

All the doctors and staff were excellent. They were courteous and very very helpful

Reviewed on Nov 11, 2021

*Dr. Nathan Mesko an amazing surgeon.

Reviewed on Nov 10, 2021

Amazing Dr and staff . Love everything about CC

Reviewed on Nov 5, 2021

Dr. Mesko, Dr. Patterson both were so kind. Helpful. Listened. Never felt rushed.

Reviewed on Oct 29, 2021

Dr Mesko and his team are superb.

Reviewed on Oct 27, 2021

Dr. Mesko was great. Going down to the crile bldg not so much. Would prefer to visit at sports clinic on transportation Blvd.

Reviewed on Oct 20, 2021

Dr. Mesko is my HERO and a HERO to my entire family as well! I am alive and thriving today because he is brilliant and I was so fortunate to receive his care and surgery. I tell everyone about him, his nurses, his team in the hospital and at his medical offices, etc. Hang onto him as he is a keeper and I look forward to receiving his care in the future should my other hip need help.

Reviewed on Oct 6, 2021

Dr Mesko is so brilliant and kind. I am grateful I. found such a good doctor and a good man.

Reviewed on Sep 29, 2021

Dr. Mesko took the time to talk to me about the results of my xrays and MRI and what the board has decided to do. He is a very caringAnd considerate doctor who cares about his patients. Any time he knew I was worried or concerned about what the results were, heWould give me a call so I wouldn't worry.

Reviewed on Sep 22, 2021

Dr Mesko is the best!

Reviewed on Sep 17, 2021

I did not schedule the appointment. Another doctor's staff who recommended Dr Mesko scheduled it. I was surprised how fast the appointment was. Very pleased

Reviewed on Sep 17, 2021

The doctor told me the surgery was risky but he is running some tests and gathering information to provide me the best picture of the benefits and risks of the surgery, then I can make a decision.

Reviewed on Sep 17, 2021

I have been seeing dr Mesko for a little over two years. I can't say anything bad about him or any of his staff. They are all so caring and they figure out what treatment is vest with me. They follow up so fast.

Reviewed on Sep 17, 2021

Dr. Masco and his staff are the best and most professional medical Professional I've ever had to be involved with! I have recommended Dr. Masco and will continue to recommend him!I never met a Doctor Who instills such confidence!

Reviewed on Sep 17, 2021

Dr. Mesko is a rare jem, to be treasured.

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