Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • 2nd Opinion Evaluations
  • Arthritis Surgery
  • Arthroplasty
  • Bone Grafting
  • Bone Tumor Surgery
  • Cancer
  • Cancer Center
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Hip & Knee Surgery
  • Hip Replacement
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Revision
  • Knee Surgery
  • Musculoskeletal Oncology
  • Orthopaedic Surgery
  • Orthopaedics
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Second Opinion
  • Soft Tissue (Sarcoma)
  • Soft Tissue Tumor Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
View all 44 Treatment & Services +

Specialty in Diseases & Conditions

  • Aneurysmal Bone Cyst
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Benign Bone Tumors
  • Bone and Soft Tissue Tumors
  • Bone Cancer
  • Bone Tumors
  • Epithelioid Hemangioendothelioma (EHE)
  • Giant Cell Tumor of Bone
  • Hip Replacement
  • Malignant Bone Tumors.
  • Malignant Peripheral Nerve Sheath Tumors
  • Osteonecrosis
  • Osteosarcoma
  • Pediatric Rare Cancer and Blood Disease Program
  • Pediatric Soft Tissue Sarcoma
  • Pigmented Villonodular Synovitis
  • Rare Cancer and Blood Disease Program
  • Sarcoma
  • Soft Tissue Sarcoma
  • Soft Tissue Tumor Pathology
View all 26 Specialties +


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About Nathan Mesko, MD

Nathan W. Mesko, MD is the Section Head of Orthopaedic Oncology and Trauma, and holds his appointment in the Orthopaedic and Rheumatologic Institute at Cleveland Clinic.  In addition, he is co-director of the Sarcoma Center in the Taussig Cancer Institute, and holds an Assistant Professorship at the Cleveland Clinic Lerner College of Medicine

After completing his college education at Wheaton College in Wheaton, Illinois, Dr. Mesko attended Loyola School of Medicine, where he was named to the Alpha Omega Alpha honor society.  He continued his residency training in orthopaedic surgery at Cleveland Clinic, followed by the pursuit of an orthopaedic oncology fellowship at Vanderbilt University (NasHVTIlle, TN).  Here, he received extensive training in benign and malignant bone and soft tissue lesions, metastatic bone and soft tissue cancer, bone and soft tissue sarcoma excision and reconstruction techniques, and complex total hip and total knee primary and revision arthroplasty.  After completing his training in NasHVTIlle, Dr. Mesko was the recipient of the Hatcher Pathology Fellowship from the Musculoskeletal Tumor Society, where he utilized this scholarship to visit various high volume sarcoma centers around the world. These efforts were intended to build further collaboration in the world of clinical and basic science outcome research between sarcoma institutions around the world, as well as to be immersed in various unique technologies.  After returning from England, Dr. Mesko joined the faculty of Cleveland Clinic in 2014.

Dr. Mesko is certified in orthopaedic surgery by the American Board of Orthopaedic Surgery.  He specializes in bone & soft tissue sarcoma diagnosis and treatment. In addition, he also specializes in the treatment of metastatic disease, as well as osteoarthritis and avascular necrosis requiring total joint arthroplasty, including hip resurfacing procedure.  His practice also encompasses total joint revision surgery.

Dr. Mesko’s research interests include clinical outcomes with bone and soft tissue sarcoma treatments, as well as working to improve educational efforts to increase sarcoma awareness.  He is part of a national team that has worked on creating a national sarcoma registry, in an effort to improve functional and cancer outcomes in this rare malignancy.  He has been active in recruiting collaborative projects from around the world to Cleveland Clinic, in an effort to make sure that patients at Cleveland Clinic are part of the latest advances in oncology care effecting the musculoskeletal system.

Outside the hospital, Dr. Mesko and his wife, raise 2 daughters and a Rhodesian ridgeback.  In addition, he enjoys spending time in regions of the world such as Africa and Central America, helping to teach and provide orthopaedic care to areas where appropriate musculoskeletal care is lacking.  Most recently, has enjoyed being a part of Hospital Shalom, a mission hospital in Flores, Guatemala.  He enjoys triathlons, downhill skiing, and water skiing as hobbies.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Vanderbilt University Medical Center
Musculoskeletal Oncology
Nashville, TN USA

Residency - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH USA

Medical Education - Loyola University Stritch School of Medicine
Chicago, IL USA

Undergraduate - Wheaton College
Wheaton, IL USA


  • Orthopaedic Surgery
Research & Publications

Research & Publications

See publications for Nathan Mesko, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/10/2020, Dr. Mesko has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Mesko receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Stryker Corporation

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

219 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.8
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

56 Patient Comments

Reviewed on Nov 6, 2020

Very clear, helpful. and went the extra mile by emailing Dr. Joyce (who I had seen previously) to give him an update.

Reviewed on Oct 28, 2020

Dr Mesko was very attentive and thorough!!

Reviewed on Sep 29, 2020

Dr. Mesko is the best.

Reviewed on Sep 18, 2020

Doctor Mesko really cares about me and my concerns. He is the best.

Reviewed on Sep 18, 2020

Dr. Mesko & his staff are awesome!

Reviewed on Sep 9, 2020

Dr. Mesko has always gone above and beyond for my care. Thank you!

Reviewed on Sep 2, 2020

Received outstanding care from *Dr. Meslo, so pleased I chose him as my surgeon.

Reviewed on Aug 26, 2020

Greatly appreciate Dr. Nathan Mesko and his team. Highly recommend Dr. Nathan Mesko for his compassion and expertise.

Reviewed on Aug 19, 2020

polite staff and doctor made me feel comfortable and relaxed

Reviewed on Aug 19, 2020

Dr Mesko is by far the absolute BEST doctor. He and his team are amazing. I am forever truly grateful for him and Cleveland Clinic.

Reviewed on Jul 1, 2020

The Resident or PA was kind, curious at attentive and made me feel calm and comfortable. Dr Mesko exuded confidence and was direct in his assessment and recommendation. I appreciated his approach and feel a tremendous sense of hopefulness that he can ease the pain I have been living with for years. He provided explanations and answered questions and made me feel like he understood my condition.

Reviewed on Jun 23, 2020

Have already recommended Dr. Mesko to numerous people

Reviewed on Jun 23, 2020

dr Mesko is the best.

Reviewed on Jun 19, 2020

I was not seen by the doctor. he was running behind. the NP with him was very rude. very rude. I had to leave because. They. were running behind two hours. the clinic should devise a system that calls wyou when your care giver is ready for you. unacceptable

Reviewed on Jun 19, 2020

you work these poor physicians to death and give them a fifteen minute time slot for something that takes 45 minutes to do. shame on you for not giving them the tools to really care for those of us who bring you millions of dollars.

Reviewed on Jun 16, 2020

Dr. Mesko is excellent! He takes time to explain everything and is very thorough. I will not go to any other orthopedic surgeon!

Reviewed on Jun 16, 2020

Dr. Mesko's staff, Rachel, Andre, his resident - thay are all top notch people! They have all been kind, courteous and fun to be around! I appreciate that we may be dealing with some very serious issues but they make me feel at ease and able to just be myself. They are not stuffy and they are still able to be very professional.

Reviewed on Jun 10, 2020

Dr. Mesko exemplifies every CC standard

Reviewed on Jun 5, 2020

Dr. Mesko is a great guy and he saved my life .

Reviewed on Jun 5, 2020

I have already told people about my doctor. he is a great guy !

Reviewed on May 29, 2020

Dr. and Staff has always treated us with kindness. very professional. I feel very blessed to have received such outstanding care for my child.

Reviewed on May 27, 2020

Dr. Mesko and Nurse Rachael Laubacher have both been amazingly helpful and proactive!

Reviewed on May 27, 2020

I came to this doctor on a previous patients recommendation. I was not disappointed. He listened to the big picture about my health, my hobbies, and what type of activity level I needed to achieve. He actually listened to me and helped me make my choice

Reviewed on May 26, 2020

Dr. Mesko and his nurse Rachael are just great about getting back to me very quickly through mychart.

Reviewed on May 22, 2020

Very highly recommend Dr. Nathan Mesko !!!!!

Reviewed on May 22, 2020

Very good experience. Highly recommend the Cleveland Clinic and my physician Dr. Mesko. Thank you for the ease of access to world class medical care.

Reviewed on May 20, 2020

Dr. Mesko is the best doctor that I have ever been to. So compassionate, professional and explains everything in detail. His entire staff is also amazing.

Reviewed on Apr 29, 2020

Dr Mesko is a great and caring doctor and I am so grateful that I found him to take care of my issue.

Reviewed on Apr 28, 2020

Dr Mesco is very caring, he also listens and answers our questions.

Reviewed on Mar 25, 2020

Dr Mesko & his staff are awesome! I would & have recommended him to friends & family members.

Reviewed on Mar 11, 2020

as usual Dr. Mesko and his staff were very respectful and responsive!

Reviewed on Mar 11, 2020

I've never had any problems or concerns with Dr. Mesko and/or his Staff!

Reviewed on Mar 6, 2020

Dr. Mesko is the best Doctor I have ever had.

Reviewed on Feb 12, 2020

Dr. Nathan Mesko is extraordinary and I chose him without reservation for my second total hip replacement.

Reviewed on Feb 7, 2020

best overall care I've ever received. Dr. Mesko is extremely professional and honest. His level of care and compassion to bring my quality of life up to where it belongs was why I chose and will continue to choose him for any future issues that may arise with my hips. He is extremely through, he answered any and all my questions before I decided to go ahead with my surgery. I can't say enough good things about him and his team of professionals that accompany him. He is a true blessing to me and my family. I'm so glad I've had the opportunity to be under his care.

Reviewed on Feb 7, 2020

Dr. Mesko and his team as well as the Cleveland clinic have set the bar in treatment of the patient. Everyone makes you feel like royalty and that you actually matter to them which is evident in the care I received. Kudos to all involved in my care.

Reviewed on Feb 7, 2020

I always have and always will continue to recommend Dr. Mesko and the Cleveland clinic to anyone who will listen to me.

Reviewed on Jan 29, 2020

I love Dr Mesko! He is thorough and listens!

Reviewed on Jan 29, 2020

Excellent experience in every part of my visit! Dr. Mesko's staff is so caring and attentive!! Dr. Mesko himself was very through in explaining the process I need to go through in order to go through the knee replacement surgeries. His PA/Nurse was so kind and attentive. Completely satisfied with whole experience.

Reviewed on Jan 29, 2020

Because of my surgery risk Every risk was explained to me in full on how the process before the surgeries will insure a safe surgery. I do have to go to a couple other Doctor's before I will be cleared for the surgery but I sm glad he took time to explain everything and why.

Reviewed on Jan 24, 2020

I've been very impressed by Dr. Mesko's staff, as well as others at CC. EVERYONE was kind, helpful and competent.

Reviewed on Jan 24, 2020

Dr. Mesko very patiently explained the problem and solution in great detail, and listened carefully to our concerns and questions. We came away with great confidence in him.

Reviewed on Jan 15, 2020

Dr. Nathan Mesko is an outstanding surgeon. He is very professional, highly skilled and compassionate.

Reviewed on Jan 15, 2020

Excellent doctor and staff!

Reviewed on Jan 14, 2020

Nathan is a star physician. He asks good questions, provides good answers to the patient. his nurse Rachael and secretary were very good. positive visit.

Reviewed on Jan 10, 2020

Dr. Mesko and Rachel seem to be the perfect team. They are wonderful. I am so happy that they are the ones taking care of me.

Reviewed on Dec 24, 2019

Dr. Mesko has a great staff

Reviewed on Dec 13, 2019

I had a very good experience with the way I was treated and the doctors were very kind and helpful explaining my problem and if the cancer ever comes back I will come back there.

Reviewed on Dec 4, 2019

Dr. Nate Mesko, his assistant and staff are remarkable.

Reviewed on Nov 26, 2019

Dr. Mesko is fabulous, I have recommended his to many of my friends and coworkers.

Reviewed on Nov 26, 2019

I have recommended friends & family members to Dr. Mesko's service & will continue to do so!

Reviewed on Nov 22, 2019

A very difficult appointment was made positive by Dr. Mesko. We are very grateful..

Reviewed on Nov 15, 2019

Dr. Mesko left our family feeling confident that our dad was in great hands.

Reviewed on Nov 13, 2019

I am extremely satisfied with Dr.Mesko and his staff/team. They been extremely knowledgeable and accessible.

Reviewed on Nov 13, 2019

Dr Mesko is an excellent doctor and has explained every thing that I wanted to know and needed to know.

Reviewed on Nov 12, 2019

both Doctor and his assistance were very caring and thorough!

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