Emergency icon Important Updates
Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon Yes
Locations Specialties & Treatments

Treatment & Services

  • Benign Soft Tissue Tumor Surgery
  • Biopsy, Musculoskeletal System
  • Bone Tumor Surgery
  • Cancer Center
  • Joint Preserving Hip Surgery
  • Knee Replacement
  • Malignant Bone Tumor Surgery
  • Malignant Soft Tissue Tumor Surgery
  • Musculoskeletal Oncology
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Sarcoma Oncologists
  • Sarcoma Surgery
  • Soft Tissue Tumor Pathology
  • Soft Tissue Tumor Surgery
View all 15 Treatment & Services +

Specialty in Diseases & Conditions

  • Aneurysmal Bone Cyst
  • Benign Bone Tumors
  • Bone Cancer
  • Bone Disorders
  • Bone Tumors
  • Cancer
  • Chondrosarcoma
  • Ewing's Sarcoma
  • Foot Benign Tumors
  • Giant Cell Tumor of Bone
  • Metastatic Bone Tumors
  • Musculoskeletal Neoplasms
  • Osteosarcoma
  • Pediatric Rare Cancer and Blood Disease Program
  • Pediatric Soft Tissue Sarcoma
  • Pediatric Tumors
  • Pigmented Villonodular Synovitis
  • Rare Cancer and Blood Disease Program
  • Rhabdomyosarcoma
  • Sarcoma
  • Soft Tissue Sarcoma
View all 21 Specialties +


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About Zachary D. Burke, MD

Zachary Burke, MD is an orthopaedic oncologist in the Sarcoma Program of the Department of Orthopedic Surgery at the Cleveland Clinic. He completed his medical and orthopaedic training at UCLA where he was inducted into the Alpha Omega Alpha (AOA) honor society. He continued his training with a fellowship in orthopaedic oncology at Mount Sinai Hospital, Princess Margaret Cancer Center, and the Hospital for Sick Children at the University of Toronto. He specializes in pediatric and adult bone sarcoma, limb sparing surgical techniques, soft tissue sarcoma, benign tumors, and metastatic bone disease. Patient-centered care is his passion.

As a surgeon-scientist, Dr. Burke is very active in research in the Cleveland Clinic Lerner Research Institute (LRI) as a translational scientist. His research interests include novel treatments for prosthetic joint infection, sarcoma therapies, and clinical outcomes in orthopaedic sarcoma surgery. He completed a research fellowship at the Orthopaedic Hospital Research Center at UCLA and was awarded a Ruth L. Kirschstein National Research Service Award (T32) from the National Institutes of Health (NIH) in support of his work. He has numerous publications in both translational science and clinical research, has authored several book chapters, and has presented widely at national and international meetings. He is a member of the American Academy of Orthopaedic Surgeons (AAOS), Musculoskeletal Tumor Society (MSTS), and Connective Tissue Oncology Society (CTOS).

Dr. Burke lives in Cleveland and devotes his time outside of the Clinic to his wife, three children, and dog.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - University of Toronto/Princess Margaret Cancer Center
Musculoskeletal Oncology
Toronto, ON Canada

Residency - UCLA Medical Center, Department of Orthopedic Surgery
Orthopedic Surgery
Los Angeles, CA

Fellowship - Orthopedic Hospital Research Center, University of California, Los Angeles (UCLA)
Postdoctoral Research Fellow
Los Angeles, CA

Internship - University of California Los Angeles Medical Center (UCLA)
General Surgery
Los Angeles, CA

Medical Education - University of California, Los Angeles (UCLA)
Los Angeles, CA

Undergraduate - Pomona College
Claremont, CA


  • Orthopaedic Surgery

Specialty Interests

Orthopedic oncology, pediatric and adult bone sarcoma, limb sparing surgical techniques, soft tissue sarcoma, benign and malignant tumors, metastatic bone disease.

Research & Publications

Research & Publications

See publications for Zachary D. Burke, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/27/2023, Dr. Burke has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

59 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Listens 4.7
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.8

9 Patient Comments

Reviewed on Apr 4, 2024

We love Dr. Burke! He has been nothing but kind and caring and showed compassion for our worries in caring for our son

Reviewed on Apr 4, 2024

OMG, Dr Burke is the 4th Dr I have seen for this issue and what a DIFFERENCE. He was kind, considerate and he LISTENED. Even though we were on video I felt we were in the same room. He talked to me as a person, he made me feel at ease, he didn't make me feel like I was a number on his wall. I am very appreciative of that

Reviewed on Feb 19, 2024

From beginning to end, the experience with Dr. Burke, his staff and Cleveland Clinic was superior.

Reviewed on Feb 19, 2024

Dr. Burke was honest and compassionate. He has a unique ability to deliver even the worst of news in a respectful manner. He kept us informed along the way and we felt very supported.

Reviewed on Feb 1, 2024

Doctor and all assistants top notch, very grateful

Reviewed on Dec 18, 2023

Dr. Burke was excellent. He answered all my questions, explained what he was seeing, and allayed my fears that a local orthopedic doctor had created when unable to diagnose what was going on.

Reviewed on Dec 18, 2023

Dr very thorough. Personable and clear communicator

Reviewed on Nov 16, 2023

Very much appreciated Dr. Burke's approach: matter-of-fact with just right amount of empathy

Reviewed on Jul 13, 2023

I have been dealing with my medical issue for we) over a year. Meeting with Dr. Burke and his resident was the first time I felt someone was listening to me.

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