Overview

Overview

Patient with rare cancer seeks care at Cleveland Clinic.
Patient with rare cancer seeks care at Cleveland Clinic.

Here at Cleveland Clinic Cancer Center, we understand the weight of a cancer diagnosis. Because of our vast expertise, we also understand the added weight of a diagnosis that is considered rare or uncommon.

Within Cleveland Clinic’s Rare Cancer and Blood Disease Program, our multidisciplinary approach is designed to provide you with the expert opinions of highly sub-specialized medical and radiation oncologists, surgeons, radiologists and pathologists focused on ensuring you are diagnosed properly before receiving treatment.

We are experienced in treating patients with rare cancers and blood disorders, and that’s why you won’t hear us mentioning how uncommon your disease is. Instead, expect options and a clinical team experienced in caring for people with your particular diagnosis.

Cleveland Clinic’s Cancer Program is ranked No. 5 in the nation by U.S. News & World Report, and is top-ranked in Ohio by the same survey. Depending on your diagnosis, your care team may also include members of the No. 1 Urology Program, No. 2 Digestive Disease & Surgery Program and the No. 3 Orthopaedic Program in the nation.

What We Treat

What We Treat

Cleveland Clinic Cancer Center offers patients the collective expertise of dozens of specialists who study, diagnose and treat uncommon diseases on a regular basis. While the below list represents many of these rare diseases, it is not a comprehensive list of what we treat. If you don’t see your diagnosis listed, please give us a call. We may still be able to help.

Solid Tumors

  • Ampullary cancer
    • Ampullary carcinoma
  • Chest wall sarcoma
    • Angiosarcomas
    • Askin’s Tumor
    • Primary soft tissue sarcomas of the chest wall
    • Radiation-Induced chest wall sarcomas
  • Epithelioid hemangioendothelioma (EHE)
  • Gastrointestinal stromal tumor (GIST)
  • Germ cell & stromal tumors of the ovary
  • Gestational trophoblastic disease
  • Gynecologic small cell neuroendocrine tumors
  • Gynecologic large cell neuroendocrine tumors
  • Gynecologic carcinoid tumors
  • Histologic variants of bladder cancer
  • Merkel cell
  • Mesothelioma
  • Non-Clear cell kidney cancer
  • Ophthalmic tumors
  • Ovarian granulosa cell tumors
  • Pagets disease of the vulva
  • Salivary gland cancer
    • Minor salivary gland cancer
    • Parotid cancer
    • Submandibular gland cancer
  • Sinonasal cancer
  • Small cell neuroendocrine carcinoma
  • Thymic cancer
  • Thyroid cancer
    • Anaplastic thyroid cancer
    • Cowden’s disease
    • Invasive thyroid cancer
    • Medullary thyroid carcinoma
    • Pendred’s syndrome
    • Radioactive iodine refractory differentiated thyroid cancer (RAIR DTC)
    • Recurrent thyroid cancer
  • Upper tract urothelial carcinoma (UTUC)
    • Renal pelvic cancer
    • Ureteral cancer
  • Uterine sarcomas
  • Uveal melanoma

Liquid Cancers

  • Amyloidosis (View more about our Amyloidosis Center)
  • Aplastic anemia
  • B-cell neoplasms
  • B-Cell prolymphocytic leukemia
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN)
  • Castleman’s disease (CD)
    • Unicentric CD
    • Idiopathic multicentric CD (iMCD)
    • iMCD-TAFRO
    • POEMS-associated MCD
  • Chronic eosinophilic leukemia
  • Dermopathies
    • Necrobiotic xanthogranuloma 
    • Schnitzler syndrome
    • Scleromyxedema
  • Hypereosinophilic syndrome (HES)
  • Chronic neutrophilic leukemia
  • Clonal hematopoiesis of indeterminate potential (CHIP)
    • Clonal cytopenias of undetermined significance (CCUS)
    • Idiopathic cytopenia of undetermined significance (ICUS)
    • Other rare myeloid disorders
  • Hairy cell leukemia
  • Histiocytic disorders
    • Langerhans cell histiocytosis
    • Erdheim-Chester disease
    • Rosai-Dorfman disease
    • Follicular dendritic cell sarcoma (FDCS)
    • Histiocytic sarcoma
    • Interdigitating dendritic cell sarcoma
    • Hemophagocytic lymphohistiocytosis
    • Macrophage-activation syndrome
  • Inherited bone marrow failure syndrome
    • Fanconi anemia
    • Dyskeratosis congenita
    • Diamond Blackfan anemia (DBA)
    • Shwachman-Diamond syndrome (SDS)
    • Severe congenital neutropenia
    • Congenital dyserythropoietic anemia
    • Congenital amegakaryocytic thrombocytopenia (CAMT)
    • Thrombocytopenia absent radii syndrome (TAR)
  • Monoclonal Gammopathy of Renal Significance (MGRS)
    • Monoclonal Immunoglobin Deposition Disease (MIDDs)
    • Lightcahin deposition disease
    • Heavy chain deposition disease
    • Proliferative Glomerulonephritis with Monoclonal Immunoglobin Deposits (PGNMID)
    • C3 Glomerulopathy with Monoclonal Gammopathy
    • Light chain proximal tubulopathy
    • Fanconi syndrome
  • Natural killer (NK) cell lymphoma/leukemia
  • Paroxysmal nocturnal hemoglobinuria (PNH)
  • Plasma cell leukemia (PCL)
  • POEMS Syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein, Skin Manifestations)
  • T-cell Large granular lymphocyte (LGL) leukemia
  • T-cell neoplasms
    • Peripheral T-cell lymphomas
    • Primary cutaneous peripheral T-cell lymphomas
    • T-Cell prolymphocytic leukemia
  • Systemic mastocytosis
  • Post-transplant lymphoproliferative disorder (PTLD)
Our Doctors

Our Doctors

Patient Services and Support

Patient Services and Support

In addition to offering state of the art diagnostic techniques and treatment methods, our specialists also offer an array of resources that can help patients cope with the demands of cancer. Patients are encouraged to take advantage of these resources to ease the burden of managing cancer.

Clinical Trials and Research

Clinical Trials and Research

Cleveland Clinic Cancer Center clinical trials offer patients access to the latest treatments and procedures resulting from cancer research.

Learn more about our Research & Innovations

Search Cancer Clinical Trials

For Medical Professionals

For Medical Professionals

Cleveland Clinic Cancer Center is committed to working with you to provide the best care for your patients. Our team is also dedicated to the training and education of medical professionals to advance cancer care and research.

Referring a Patient

Cleveland Clinic welcomes the opportunity to partner with you in caring for your patients. Our dedicated Referring Physician team is available around-the-clock and committed to serving you and your patients. Please contact our Referring Physician Hotline, available 24 hours a day, 7 days a week, for all your needs, by calling 855.REFER.123 (855.733.3712).

View all of our resources for Medical Professionals