Our Bone Marrow Failure and Cytopenias Program was founded on the realization that patients with uncommon diseases can only receive world class care when their providers have a vast experience in seeing patients with these rare diagnoses and who are familiar with all the intricacies of care needed to treat these uncommon, hematologic conditions. A select number of hematologists at Cleveland Clinic with a long-standing clinical and research track record in these diseases have organized working groups which combine multiple specialists from several disciplines who diagnose and treat these rare conditions.

Multi-disciplinary team

Our team consists of subspecialties involved in the care of these rare disorders including hematologists, bone marrow transplant specialists, hematopathologists and geneticists.  We are also supported by pharmacy specialists, highly trained nursing care and a clinical trial research team. We have a long-standing track record of collaboration with patient advocacy groups. Cleveland Clinic Hematologist and program director Jaroslaw Maciejewski, MD, PhD is a member of multiple medical advisory groups that help with national recommendations and treatment standards for these diseases.

We are a top research center for Bone Marrow Failures and Cytopenias in the United States. Program Director Jaroslaw Maciejewski MD, PhD, is an internationally renowned expert in these diseases. Our program has a track record of pivotal discoveries in this field with over 350 publications and participation in crucial clinical trials for these diseases. Eligible patients may participate in laboratory research and clinical registries.


We are one of the largest referral centers in the United States. Since 2002, we have seen more than:

Our team has performed over 50 allogeneic bone marrow transplant procedures for aplastic anemia. We treat patients from all over the United States and internationally and provide the option of virtual visit consultations to enable access to our expertise for patients who cannot travel.

We offer:

  • Comprehensive diagnostic evaluation and multidisciplinary treatment.
  • Evaluation of treatment received or receiving and confirmation of diagnosis.
  • Genetic/genomic evaluation of your case.
  • Diagnostic workup of unclear and complicated cases.

We welcome appointments for:

  • Newly diagnosed patients or those who suspect they have one of the rare conditions we treat.
  • Second opinion referred by doctors or self-referred.
  • Patients seeking clinical trials.
  • Virtual visits and consultations.
What We Treat

What We Treat

Bone marrow failure and cytopenias include a variety of diseases and syndromes. Most hematologists include myelodysplastic syndromes in the bone marrow failure classification and there is a great deal of overlap. Others consider myelodysplastic syndromes as a form of myeloid leukemia or pre-leukemia. We also collaborate with pediatric hematologists and oncologists in the diagnosis and management of inherited forms of bone marrow failure occurring in childhood.


  • Idiopathic aplastic anemia.
  • Idiopathic neutropenia.
  • Autoimmune neutropenia.
  • Amegakaryocytic thrombocytopenic purpura.
  • Cytopenias of myelodysplastic syndrome (MDS).
  • Other unclear cytopenias.
  • Pure red cell aplasia.
  • Idiopathic.
  • B19 parvovirus related/Transient aplastic crisis.
  • Paroxysmal nocturnal hemoglobinuria.
  • Large granular lymphocyte leukemia/lymphoproliferation.
    • NK-LGL.
    • T-LGL.


  • Congenital dyserythropoietic anemia.
  • Congenital amegakaryocytic thrombocytopenia (CAMT).
  • Diamond Blackfan anemia (DBA).
  • Dyskeratosis congenital.
  • Fanconi anemia.
  • Idiopathic and autoimmune neutropenia.
  • Severe congenital neutropenia.
  • Cyclic neutropenia.
  • Shwachman-Diamond syndrome (SDS).
  • Thrombocytopenia absent radii syndrome (TAR).

Related programs

Our Doctors

Our Doctors

This group of disorders encompasses several rare hematologic diseases. Highly specialized physicians who have vast experiences in diagnosing, managing and treating these disorders created this program to provide the most comprehensive care for these conditions. We are located at Cleveland Clinic’s main campus.


Hetty Carraway, MD
Hetty Carraway, MD
Director of the Leukemia Program
Abhay Singh, MD, MPH
Abhay Singh, MD, MPH
Associate Staff

Bone marrow transplant

Ronald Sobecks, MD
Ronald Sobecks, MD
Quality Review Officer


James Cook, MD, PhD
James Cook, MD, PhD
Section Head, Hematopathology

Molecular Hematology

David Bosler, MD
David Bosler, MD
Department Chair

Medical genetics

  • Brittany Griffin, MS, CGC, PhD
Support and Resources

Support and Resources

Patient services

In addition to offering state of the art diagnostic techniques and treatment methods, our specialists offer an array of resources that can help patients cope with the demands of rare hematologic disorders. Patients are encouraged to take advantage of these resources to ease the burden of managing their disease.

Patient stories


Clinical Trials Research

Clinical Trials Research

Many clinical trials of new treatments or combinations of treatments are available for patients with Bone Marrow Failures or Cytopenias. If your Cleveland Clinic doctor feels you might benefit from participating in a clinical trial, the options will be discussed with you in detail. Clinical trials (or research studies) help us create the medicine of tomorrow. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are widely available. We can help you access hundreds of clinical trials across all specialty areas. Our new searchable online trials tool makes identifying treatment opportunities easier than ever.

Medical Professionals

Medical Professionals

Cleveland Clinic Cancer Center is committed to working with you to provide the best care for your patients. Our team is also dedicated to the training and education of medical professionals to advance cancer and hematologic disease care and research.

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Pathology second opinion

Cleveland Clinic Laboratories offers second opinion pathology consultations for surgical pathology, cytology, and hematopathology cases.

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