Cleveland Clinic is dedicated to being a leader in patient experience, clinical outcomes, research, and education for patients with amyloidosis. Specialists in our Cancer Center and Sydell and Arnold Miller Family Heart & Vascular Institute work together to provide the most advanced treatment options for patients with amyloidosis. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s top hospitals in its annual “America’s Best Hospitals” survey and has named Cleveland Clinic’s heart program No. 1 in the nation since 1995.

A Team Approach

Depending on the symptoms and type of amyloidosis, there will be different specialty doctors involved. The initial evaluation will be done by one of our amyloid specialists in cardiology or cancer care, with possible additional involvement of specialists in neurology, nephrology, gastroenterology, hematology/oncology, genetics and primary care. Together, our amyloid specialists explore all options and tailor the most appropriate treatment plan for each patient, taking into consideration your goals and quality of life. Each patient will also have a patient care coordinator to help coordinate appointments with the various specialists involved. The Amyloidosis Center is led by co-directors Jason Valent, MD, from Hematology and Medical Oncology, and Mazen Hanna, MD, from Cardiovascular Medicine.

Patient Story

Dallas Physician-turned-patient Travels to Cleveland Clinic for Specialized Complex Care

Learn more about Manuel Rivera-Alsina, a former physician, Navy member and triathlete, who came to Cleveland Clinic where doctors discovered he had AL Amyloidosis. After undergoing heart, bone marrow and stem cell transplants, he is now fully recovered and running again.

View Manuel's Story
What We Treat

What We Treat

Amyloidosis (am-uh-loy-doh-sis) is a protein disorder. In this disease, proteins change shape (misfold), then clump together and form amyloid fibrils which deposit in organs. As amyloid fibrils build up, the tissues and organs may not work as well as they should.

Our bodies make several proteins that can cause amyloidosis. To choose the right treatment, it is very important to know the exact protein that is causing the disease. The two most common types are light chain (AL) and transthyretin (ATTR) amyloidosis.

Proteins change shape (misfold) then clump together and form amyloid fibrils.

Learn More

To learn more about the most common types of amyloidosis, please click on the links below:



The Amyloidosis Center brings together specialists in cardiology, cancer care, neurology, nephrology, gastroenterology, hematology/oncology, genetics and primary care.

Our Medical Team






Genetic Counselors

  • Christine Rigelsky
  • Brittany Psenske
  • Diane Clements
Care Team

Care Team

Along with our physicians, Cleveland Clinic’s Amyloidosis Center is comprised of several other valuable team members who assist patients throughout their cancer treatment.

Mary Ann Karam, RN, BSN Care Coordinator Mary Ann Karam, RN, BSN
Care Coordinator
Janice Reed, RN, BSN Care Coordinator Janice Reed, RN, BSN
Care Coordinator
Kristen Schleuter, RN Care Coordinator Kristen Schleuter, RN
Care Coordinator
Kathleen Stefunek, RN Research Nurse Kathleen Stefunek, RN
Research Nurse
Nathan Rosko, PharmD Nathan Rosko, PharmD
Clinical Pharmacy Specialist
Support & Services

Support & Services

In addition to offering state of the art diagnostic techniques and amyloidosis treatments, our specialists also offer an array of resources that can help patients cope with the demands of a chronic disease.

Additional External Resources

Clinical Trials & Research

Clinical Trials & Research

Clinical trials (or research studies) help us create the medicine of tomorrow. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are widely available.

We can help you access hundreds of clinical trials across all specialty areas. Our new searchable online trials tool makes identifying treatment opportunities easier than ever.

Generous philanthropic donations have enabled the creation of the Cleveland Clinic Term Chair in Amyloid Heart Disease, which has helped fund numerous studies and allowed for the creation of a dedicated research fellow position to further our work in the field.  The Cleveland Clinic Amyloidosis Center has participated in all of the major multi-center treatment trials in AL and ATTR amyloidosis, and readily collaborates with the national and international amyloidosis community to promote advancements in therapies and our understanding of the disease.

Clinical trials of new treatments are available for patients with amyloidosis.  Our team at Cleveland Clinic is a leader in research efforts to develop diagnosis and treatment strategies to improve our patients’ outcomes.  Cleveland Clinic offers several clinical trials for patients with amyloidosis.  If your Cleveland Clinic amyloidosis specialist feels you might benefit from participating in a clinical trial, the options will be discussed with you in detail.

Current and Upcoming Trials

 Ongoing Trial, Closed to Recruitment

Completed Trials

Medical Professionals

Medical Professionals

Cleveland Clinic is committed to working with you to provide the best care for your patients. Our team is also dedicated to the training and education of medical professionals to advance care and research of amyloidosis.

To refer a patient, please contact our Referring Physician Hotline, available 24 hours a day, 7 days a week, for all your needs, by calling 855.REFER.123 (855.733.3712).