Patients treated by the Solid Tumor team benefit from having experts in pediatric tumors develop a multi-disciplinary treatment plan. Our solid tumor team is made up of pediatric oncologists, an oncology nurse practitioner, and a care coordinator who see children, adolescents, and young adults with rare and common varieties of cancer that occur in young people. We work closely with surgeons, interventional radiologists, and radiation oncologists to not only accurately diagnose, but to develop a family centered treatment plan. We have world-class expertise in providing outpatient cancer treatment. A solid tumor nurse coordinator also facilitates patient visits and scheduling. The solid tumor team also has a dedicated social worker to help access resources for a more normal life of not only the patients, but caregivers, too.
Patients who receive solid tumor treatment at Cleveland Clinic Children’s build a therapeutic alliance with their caregivers and our team to achieve an active life while on therapy and after treatment. In addition to the individual attention patients receive from their primary oncologists, they benefit from the collective expertise of the entire Department of Pediatric Hematology, Oncology, & Blood and Marrow Transplantation.
Our treatment group remains actively involved in the oversight and process of continuous improvement of every patient’s care by discussing patients’ needs and treatment on a regular basis. Each week, the team of physicians, nurse practitioner, nurse coordinator, and social worker reviews patients currently on active therapy and make plans for the upcoming week and month to ensure well-coordinated, family-centered care.
What We Treat
The Solid Tumor team treats a wide variety of disorders. Some of the more common conditions we treat are:
Desmoplastic Small Round Cell Tumor (DSRCT)
Desmoplastic Small Round Cell Tumor (DSRCT) is a type of cancer, usually found in the abdomen, but it can also occur in other parts of the body. The tumors are formed by small, round cancer cells and are surrounded by scar-like tissue.
Ewing sarcoma is a cancerous tumor that grows in bones or soft tissue near bones. It can develop anywhere in the body, but most commonly affects the arms, legs, ribs, spinal column, and pelvis.
Hepatoblastoma (Liver Cancer)
Hepatoblastoma is a rare tumor that originates in cells in the liver. It is the most common cancerous liver tumor in early childhood. Hepatoblastoma is typically found in babies and children up to age 3.
In Neuroblastoma, a solid tumor is formed by aspecial nerve cells called neuroblasts. Normally, these immature cells grow into functioning nerve cells. But in neuroblastoma, they become cancer cells instead.
Osteosarcoma is the most common type of bone cancer. Although other types of cancer can eventually spread to parts of the skeleton, osteosarcoma is one of the few that actually begins in the bones. Because osteosarcoma usually develops from osteoblasts (the cells that make growing bone), it most commonly affects teens who are having a growth spurt.
Paranganglioma is a rare tumor that forms in the neuroendocrine system. Paragangliomas form in the nerve tissue in the adrenal glands and near certain blood vessels and nerves. Paragangliomas that form in the adrenal glands are called pheochromocytomas.
Retinoblastoma is a cancerous tumor that grows in the retina, a layer of nerve tissue in the back of the eye that sense light and sends images to the brain. A cancer of early childhood, retinoblastoma can affect developing fetuses in the womb, as well as newborns, babies, toddlers, and children up to 5 years old.
Rhabdomyosarcoma is a cancerous tumor that develops in the body’s soft tissues, usually the muscles. It can affect the head, neck, bladder, arms, legs, trunk, or just about any body part. Cells from rhabdomyosarcoma are often fast growing and can spread to other parts of the body.
Also known as nephroblastoma, Wilms tumor can affect both kidneys, but usually develops in just one. Doctors believe the tumor begins to grow as a fetus develops in the womb, with some cells that are destined to form into the kidneys malfunctioning and forming a tumor.
- Crystal Chisler, CNP
- Taylor Buss, MSW, LSW
The Children's Oncology Group has nearly 100 active clinical trials open at any given time and more than 90% of children with cancer are cared for at a COG site. These trials include front-line treatment for many types of childhood cancers, studies aimed at determining the underlying biology of these diseases, and trials involving new and emerging treatments, supportive care, and survivorship. In addition to running clinical trials with the Children’s Oncology Group, our team has trials open with pharmaceutical sponsors as well as trials initiated by our own physicians.
Below is a list of open solid tumor clinical trials available at Cleveland Clinic Children’s Department of Pediatric Hematology, Oncology, and Blood & Marrow Transplantation:
- 2125-RST-101: (Idera Pharmaceuticals, Dr. Peter Anderson) A Phase 1b Study of Intratumoral IMO-2125 in Patients with Refractory Solid Tumors
- CL-PTL-121: (Gradalis, Dr. Peter Anderson) Randomized Phase IIb Trial of Vigil™ (bishRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) versus gemcitabine + docetaxel for Ewing’s Sarcoma
- COG ADVL1622: Phase 2 Trial of XL184 (Cabonzantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors
- COG AEWS1221: Randomized Phase II Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# 750008, IND# 120449) to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma
- COG AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
- COG AHEP0731: Treatment of Children with All Stages of Hepatoblastoma with Temsirolimus (IND# 122782, NSC# 683864) Added to High Risk Stratum Treatment
- COG ANBL1231: Utilizing Response- and Biology-based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma
- COG AOST1321: Phase 2 Study of Denosumab (IND# 127430, NSC# 744010), a RANK Ligand Antibody, for Recurrent or Refractory Osteosarcoma
- COG ARST1321: Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754, IND# 118613)
- COG Pediatric MATCH Protocols: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice Master Version)
- ONC201: (PI Initiated Trial, Dr. Peter Anderson) Phase 2 Study of ONC201 in Neuroendocrine Tumors
If you are interested in learning more about a COG trial, please contact:
Aron Flagg, MD
COG Principal Investigator
If you are interested in any of our sponsor or PI-initiated studies, please contact:
Peter Anderson, MD
For information or to make an appointment for an in-person or virtual visit, please call 216.444.5517.
Patients can also be seen via Virtual Visit. Patients use the Cleveland Clinic Express Care® Online tool to see our providers online from the comfort of their home. This service allows patients a fast, secure, and easy way to receive care from their healthcare team in a live virtual visit using a smartphone, tablet, or computer. The benefits of choosing a virtual visit include no travel or parking, less waiting, significant time savings, no facility fee and the convenience of seeing your physician from wherever you choose.
Note: All patients looking to schedule virtual visits must have a Cleveland Clinic Medical Record Number (MRN). If you do not have a Cleveland Clinic MRN, please call the appropriate number below and they will be able to assist you in getting your record created.
- USA: 216.444.5437
- International (including Canada): 216.444.8184
Members of our Solid Tumor Team can be seen at Cleveland Clinic Main Campus:
Cleveland Clinic Main Campus – R Building
8950 Euclid Ave.
Cleveland, OH 44195