Uterine Cancer

Overview

What is uterine cancer?

Uterine cancer is a general term that describes cancers of the uterus, or womb:

  • Endometrial cancer develops in the endometrium, the inner lining of the uterus. It’s one of the most common gynecologic cancers — cancers affecting a woman’s reproductive system.
  • Uterine sarcoma develops in the myometrium, the muscle wall of the uterus. Uterine sarcomas are very rare.

Are endometrial cancer and uterine cancer the same?

Uterine cancer can refer to either endometrial cancer, uterine sarcoma or other rare forms of cancer that arises in the uterus. But people often treat the terms “endometrial cancer” and “uterine cancer” the same. That’s because endometrial cancers are much more common than other cancers that arise in the uterus.

What does the uterus do?

The uterus is part of the female reproductive system. It’s where a baby grows and develops during pregnancy.

The top part of the uterus is called the body or corpus. At the end of the uterus is the cervix, which connects the uterus to the vagina. Uterine cancer refers to cancer in the body of the uterus. Cancer in the cervix — cervical cancer — is a separate type of cancer.

What does the endometrium do?

The endometrium is the inner layer of the uterus. It changes during the menstrual cycle.

A hormone called estrogen causes the endometrium to thicken in case of pregnancy. If no pregnancy occurs, the body produces less estrogen and more progesterone, a different hormone. When that happens, the endometrial lining sheds. That’s when periods take place.

Who’s at risk for uterine cancer?

There are several risk factors for endometrial cancer. Many of them relate to the balance between estrogen and progesterone. These include morbid obesity, a condition called polycystic ovarian syndrome or taking unopposed estrogen. A genetic disorder known as Lynch syndrome is another risk factor unrelated to hormones.

Risk factors include:

Age, lifestyle and family history:

  • Age: As women get older, the likelihood of uterine cancer increases. Most uterine cancers occur after age 50.
  • Diet high in animal fat: A high-fat diet can increase the risk of several cancers, including uterine cancer. Fatty foods are also high in calories, which can lead to obesity. Extra weight is a uterine cancer risk factor.
  • Family history: Some parents pass on genetic mutations (changes) for hereditary nonpolyposis colorectal cancer (HNPCC). This inherited condition raises the risk for a range of cancers, including endometrial cancer.

Other conditions:

  • Diabetes: This disease is often related to obesity, a risk factor for cancer. But some studies suggest a more direct tie between diabetes and uterine cancer as well.
  • Obesity (having excess body weight): Some hormones get changed to estrogen by fat tissue, raising uterine cancer risk. The higher the amount of fat tissue, the greater the effect on estrogen levels.
  • Ovarian diseases: Women who have certain ovarian tumors have high estrogen levels and low progesterone levels. These hormone changes can increase uterine cancer risk.

Menstrual and reproductive history:

  • Early menstruation: If periods start before age 12, risk for uterine cancer might increase. That’s because the uterus gets exposed to estrogen for more years.
  • Late menopause: Similarly, if menopause occurs after age 50, risk also increases. The uterus gets exposed to estrogen longer.
  • Long menstruation span: The number of years menstruating might be more important than your age when periods started or ended.
  • Not getting pregnant: Women who have not been pregnant have a higher risk because of the increased exposure to estrogen.

Previous treatments for other conditions:

  • Earlier radiation therapy to the pelvis (between belly and legs): Radiation therapy to treat other cancers can damage cell DNA. This damage may increase the risk of a second type of cancer.
  • Estrogen replacement therapy (ERT): Some people receive estrogen therapy to help relieve menopause symptoms. Women who get ERT without progesterone face a higher risk for uterine cancer.
  • Use of tamoxifen: People may receive this drug for breast cancer treatment. It acts like estrogen in the uterus and can increase the risk of uterine cancer.

How common is uterine cancer?

In the United States, endometrial cancer is the most common cancer affecting a woman’s reproductive system. It mostly affects women after menopause. About 3% of women receive a diagnosis of uterine cancer at some point during their lives.

Symptoms and Causes

What causes uterine cancer?

Researchers are not sure of the exact cause of uterine cancer. Something happens to create changes in cells in the uterus. The mutated cells grow and multiply out of control, forming a mass called a tumor.

Certain risk factors can increase the chances you’ll develop uterine cancer. If you’re at high risk, talk to your healthcare provider about steps you can take to protect your health.

What are the symptoms of uterine cancer?

Signs of uterine cancer can resemble those of many conditions. That’s especially true of other conditions affecting reproductive organs. If you notice unusual pain, leaking or bleeding, talk to your healthcare provider. An accurate diagnosis is important so you can get the right treatment.

Symptoms of endometrial cancer or uterine sarcoma include:

  • Vaginal bleeding between periods in women before menopause.
  • Vaginal bleeding or spotting in postmenopausal women, even a little amount.
  • Lower abdominal pain or cramping in the pelvis, just below the belly.
  • Thin white or clear vaginal discharge in postmenopausal women.
  • Extremely long, heavy or frequent vaginal bleeding in women older than 40.

Diagnosis and Tests

How is uterine cancer diagnosed?

Talk to your healthcare provider if you notice possible signs of uterine cancer. Your provider will:

What tests will I need to diagnose uterine cancer?

Your provider may perform one or more tests to confirm a diagnosis of uterine cancer:

Lab tests:

  • CA-125 assay is a blood draw that measures CA-125, a protein. A certain amount of CA-125 can point to cancer in the body.

Imaging tests:

  • CT scans take a series of detailed pictures of the inside of the body.
  • MRI scans use radio waves and a powerful magnet to create images.
  • Transvaginal ultrasound inserts a special probe (smooth, rounded device) into the vagina to get pictures of the uterus.

Other tests:

  • Endometrial biopsy inserts a thin, flexible tube through the cervix (opening of the vagina) and into the uterus. The provider removes a small amount of the endometrium.
  • Hysteroscopy inserts a hysteroscope, a long thin tube, through the vagina and cervix to reach the uterus. This narrow instrument with a light and camera provides detailed images of the uterus.
  • Dilation and curettage (D&C) is a more complex procedure to remove uterine tissue. It takes place in the operating room.

If you had a D&C or biopsy to remove tissue samples, your provider then sends the sample to a lab. There, a pathologist looks at the tissue to confirm if there’s cancer.

Can a Pap test diagnose uterine cancer?

The Pap test (Pap smear) does not screen for or diagnose uterine cancer. It checks for cervical cancer.

What else does an endometrial cancer diagnosis show?

If healthcare providers diagnose endometrial cancer, they also need to determine the type. The type helps the care team figure out the best treatment:

  • Type 1 endometrial cancers are less aggressive. They usually don’t spread to other tissues quickly.
  • Type 2 endometrial cancers are more aggressive. They’re more likely to spread outside of the uterus and need stronger treatment.

Management and Treatment

How is uterine cancer treated?

Most people with endometrial cancer need surgery. Your particular treatment plan depends on the type of cancer and your overall health. Other treatments you may have include:

  • Chemotherapy, which uses powerful drugs to destroy cancer cells.
  • Radiation therapy, which sends targeted radiation beams to destroy cancer cells.
  • Hormone therapy, which gives hormones or blocks them to treat cancer.
  • Immunotherapy, which helps your immune system fight cancer.
  • Targeted therapy, which uses medications to target specific cancer cells to stop them from multiplying.

Researchers continue to study more ways to treat endometrial cancer. You may qualify for a clinical trial.

What type of uterine cancer surgery will I need?

Surgery is usually the main treatment for endometrial cancer. You’ll most likely have a hysterectomy, with the surgeon removing the uterus and cervix. There are three types of hysterectomy procedures:

  • Total abdominal hysterectomy: The surgeon makes an incision (cut) in the abdomen to access and remove the uterus.
  • Vaginal hysterectomy: The surgeon removes the uterus through the vagina.
  • Radical hysterectomy: If the cancer has spread to the cervix, you may need a radical hysterectomy. The surgeon removes the uterus and the tissues next to the uterus. The surgeon also removes the top part of the vagina, next to the cervix.

During a hysterectomy, surgeons often perform two other procedures as well:

Do I need to have my ovaries removed?

Many people who have uterine cancer need their ovaries removed. But removing the ovaries means you will go through menopause if you haven’t already. If you’re younger than 45 and premenopausal, talk to your care team to see if you can keep your ovaries.

What can I expect after uterine surgery?

Side effects of uterine cancer surgery include:

  • Infertility, not being able to get pregnant.
  • Menopause (if you were premenopausal) and its symptoms, including vaginal dryness and night sweats.

How is a uterine sarcoma treated?

Often, surgeons use a single procedure to diagnose, stage (describe severity) and treat uterine sarcoma. Treatment options are like those for endometrial cancer. Most women have a hysterectomy, as well as a BSO to remove the ovaries and fallopian tubes.

Prevention

Can uterine cancer be prevented?

Most of the time, you can’t prevent uterine cancer. But you can take steps to reduce your risk:

  • Control diabetes.
  • Maintain a healthy weight.
  • Talk to your provider about using oral contraceptives. These medications can offer some protection against uterine cancer.

Will estrogen replacement therapy make me more likely to get uterine cancer?

If you are considering ERT, talk to your healthcare provider. Together, you can discuss your cancer risk and make the decision that’s best for you.

Is there a screening test for uterine cancer?

No, there’s no screening tool. And healthcare providers usually don’t recommend regular testing for women without symptoms. They may do so for women at higher risk, though. If you’re at high risk, talk to your provider about regular checks for uterine cancer.

Outlook / Prognosis

What’s the outlook for people with uterine cancer?

The National Cancer Institute reports that the five-year survival rate for endometrial cancer is 81%. That means 81% of people diagnosed with the disease are alive five years later. The rate is even higher when cancer is localized and hasn’t spread outside the uterus. Then the survival rate reaches as high as 95%. Treatments continue to improve, along with survival rates.

Can uterine cancer be cured?

Fortunately, endometrial cancer is often diagnosed at an early stage. That’s because many women notice unusual bleeding and tell their healthcare providers. If cancer gets caught early and hasn’t spread to other organs, removing the uterus can cure it.

Living With

When should I see my healthcare provider?

The American Cancer Society says to discuss any unusual bleeding or spotting with a provider. If you’ve inherited endometrial cancer risk, talk to your provider about yearly testing. You may need an endometrial biopsy every year, starting at age 35.

What should I ask my healthcare provider?

If you’ve received a uterine cancer diagnosis, ask your provider:

  • What is the cancer’s stage?
  • What treatment options will be best for me?
  • Will I need more than one treatment?
  • Are there clinical trials I can take part in?
  • What’s the goal of treatment?
  • What can I expect after treatment?
  • Will cancer come back?
  • Am I at high risk for other cancers?

How can I take care of myself after uterine cancer treatment?

After you finish treatment, your care team will talk to you about your follow-up visits. It’s important to go to these appointments. During a follow-up visit, your provider will do a pelvic exam. They’ll also ask you about any symptoms. The goal is to make sure cancer isn’t coming back and that you’re feeling OK after treatment.

You can also talk to your provider about ways to live a healthier life after cancer. Eating well, getting enough sleep and exercising can help you feel your best.

A note from Cleveland Clinic

Uterine cancer includes endometrial cancer (more common) and uterine sarcoma. The disease is the most common cancer affecting a woman’s reproductive system. It usually happens after menopause. But it can affect younger women, too. Uterine cancer symptoms include vaginal bleeding between periods or after menopause. If healthcare providers catch uterine cancer before it spreads, surgery can cure it. If you experience any signs of uterine cancer, contact your healthcare provider.

Last reviewed by a Cleveland Clinic medical professional on 01/20/2021.

References

  • Centers for Disease Control and Prevention. Uterine Cancer. (https://www.cdc.gov/cancer/uterine/pdf/uterine_facts.pdf) Accessed 1/15/2021.
  • National Cancer Institute. Cancer Stat Facts: Uterine Cancer. (https://seer.cancer.gov/statfacts/html/corp.html) Accessed 1/15/2021.
  • National Cancer Institute. Uterine Cancer — Patient Version. (https://www.cancer.gov/types/uterine/patient/uterine-sarcoma-treatment-pdq) Accessed 1/15/2021.
  • National Cancer Institute. Uterine Sarcoma Treatment—Patient Version. (https://www.cancer.gov/types/uterine/patient/uterine-sarcoma-treatment-pdq) Accessed 1/15/2021.
  • U.S. Department of Health & Human Services. Office on Women’s Health. Uterine Cancer. (https://www.womenshealth.gov/cancer/uterine-cancer) Accessed 1/15/2021.
  • American Cancer Society. Survival Rates for Endometrial Cancer. (https://www.cancer.org/cancer/endometrial-cancer/detection-diagnosis-staging/survival-rates.html) Accessed 1/15/2021.

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