Mellen Center for Multiple Sclerosis focuses on addressing physical, emotional, cognitive and rehabilitation needs of the MS patient and their family members through a team approach. Mellen Center for Multiple Sclerosis offers state-of-the-art resources to provide the most advanced specialized care, supported by an extensive program of research and education. The Mellen Center is one of the largest and most comprehensive programs for MS care and research worldwide, managing more than 20,000 patient visits every year. Basic and clinical research conducted at Cleveland Clinic sheds new light on MS every year.
Mellen Center physicians are national leaders in basic and clinical research related to MS pathogenesis and medical management and have made major contributions in the development of drugs to control MS disease activity and progression. The Mellen Center is the largest comprehensive program for MS care and research worldwide, managing more than 8,000 patients and more than 21,000 total visits every year. Basic and clinical research conducted at Cleveland Clinic sheds new light on MS every year, moving us ever closer to better treatments and hopefully, one day soon, a cure.
Program highlights for the Mellen Center include:
- clinical research
- Integration of neurorehabilitation with spasticity management through the use of baclofen pumps and Botox injections
- Standard and investigational imaging provided through the 3 Tesla MR imaging facility, staffed by an expert team
- Latest pharmaceutical therapies delivered in a comfortable 12-chair infusion center
Central to our philosophy is the importance of meeting your social and psychological needs, as well as your complex physical needs. At the Mellen Center, you will experience a supportive, welcoming atmosphere and receive assistance in managing the different aspects of MS so you will not feel overwhelmed.
If you have medical concerns beyond the immediate scope of the Mellen Center, you can benefit from the center's unique position as part of the world-renowned Cleveland Clinic, where a complete range of specialists and state-of-the-art treatments ensure that you will receive care that meets all your needs at each of our locations which include: Main Campus, Hillcrest Hospital and Fairview Hospital in Ohio.
The team in Cleveland Clinic's Mellen Center for Multiple Sclerosis recognizes that whether you have been newly diagnosed with multiple sclerosis or have been living with multiple sclerosis for many years, you can be left with a lot of unanswered questions or overwhelmed by on-going management of the disorder. To help, we now offer two ways to quickly and conveniently see a multiple sclerosis specialist online using the Cleveland Clinic Express Care® Online tool.
- Informational assessment: Receive an informational assessment from the world’s leader in multiple sclerosis research and patient care, no physician referral required. Let our specialists answer your most pressing questions, provide personalized education and share insights into how we manage care for individuals with multiple sclerosis.
- Established patient appointment: Receive follow-up or on-going care directly from your MS team. Benefits of choosing this appointment option include no travel or parking, no facility fees, less waiting, significant time savings and the convenience of seeing a specialist from wherever you choose.
If you would like to use Express Care Online for your initial informational assessment or next established patient visit, please call the Mellen Center office in Cleveland, Ohio at 216.444.8600 or toll-free 866.588.2264, Monday through Friday, between 8 a.m. and 5 p.m. If you are eligible, our team will schedule your virtual visit and provide details on the visit cost and setup instructions.
What We Treat
Diseases & Conditions
- Acute Disseminated Encephalomyelitis
- Multiple Sclerosis
- Neuromyelitis Optica (Devic's Disease)
- Optic Neuritis
- Pediatric Multiple Sclerosis
- Primary Progressive Multiple Sclerosis
- Relapsing Remitting Multiple Sclerosis
- Secondary Progressive Multiple Sclerosis
- Transverse Myelitis
Diagnostics & Testing
- Evoked Potentials
- Lumbar Puncture
- Magnetic Resonance Imaging (MRI)
- Neuropsychological Evaluations
- Optical Coherence Tomography
Treatments & Services
The Mellen Center for Multiple Sclerosis offers comprehensive care for the treatment of multiple sclerosis.
View our specialists below:
Make an Appointment
To make an appointment with a Mellen Center for Multiple Sclerosis specialist in:
- Cleveland, Ohio - call 216.636.5860 or 866.588.2264.
- Las Vegas, Nevada - call 702.483.6000 or 866.588.2264.
Please refer to Care at the Mellen Center to learn what to expect and how to prepare for an appointment for you or a loved one.
Whether you're a new or existing patient, you can get an initial evaluation or follow-up care from a multiple sclerosis specialist using your phone, tablet or computer. This means there's no travel or parking, less waiting and significant time savings. Call 216.636.5860 to schedule a virtual visit for you or a loved one and get details on cost and set-up instructions.
If you or a loved one suffers from multiple sclerosis meet with our nationally-renowned specialists for a virtual education visit, no physician referral required. Let our specialists answer your most pressing questions, provide personalized education and share insights into how we manage care for individuals with multiple sclerosis. If you would like to use Express Care Online for an educational visit, please sign in to or establish a login for Express Care Online. Once logged in navigate to “Multiple Sclerosis Education” and select the “Schedule” button where you will be able to schedule a visit that’s convenient for you.
MyChart connects you to your health care team from the comfort and safety of home. With this secure, online tool you can manage your appointments and complete pre-visit tasks, communicate with your providers, and keep track of your test results and medications.
Multiple Sclerosis Performance Test
The Multiple Sclerosis Performance Test (MSPT) is a new feature from Cleveland Clinic for patients to enhance their current care and better establish trends in the management of their Multiple Sclerosis. The MSPT is an iPad-based assessment of neurological function that includes health status questionnaires, a 25-foot walking speed test, 9-hole peg manual dexterity test, plus new assessments of processing/thinking speed and visual function.
The results of the tests are immediately available to your provider for use at the time of your visit, so it is important to complete the testing prior to the visit with your care provider.
Please note, your visit to the Mellen Center for Multiple Sclerosis will be structured as follows:
- 20 minutes with a Medical Assistant including vital signs, review medication list, standard nursing intake questions
- 30 minutes for MSPT
- 45 minute appointment with your care provider
Please arrive at the time noted on your appointment reminder or in MyChart, but know that your visit will consist of more than just the 45 minutes that you spend with your provider.
In MyChart reminders – the details about the appointment time will not reflect this new structure, but the arrival time is accurate. Other appointment reminders will detail the breakdown of the various appointments that now comprise your total visit at the Center. Completing health status questionnaires in advance of your visit from home via MyChart will save approximately 10 minutes on the day of your appointment.
Image Copy Request
When requesting a copy of radiology images, please allow a minimum of a 48-hour advance notice for all procedures conducted at any of our imaging centers.
The link below takes you to our secure website where you can request your images electronically.
All CDs will be sent to your home address via UPS.
Clinical Trials & Research
Multiple Sclerosis Research Programs
The Neurological Institute advances research into disease of the brain and spine and conducts clinical therapeutic trials to support patients with neurological disorders. Our multidisciplinary research collaboration combines the expertise of clinical principal investigators with state-of-the-art imaging and data analysis to establish and implement new approaches to the treatment of neurological diseases. In addition, the Neurological Institute trains clinical fellows, full-time research fellows, and residents as next generation clinical research scientists.
Clinical trials and research are the key for advancing medial knowledge and patient care. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are available.
- Access our multiple sclerosis clinical trials
- Learn about our multiple sclerosis research programs
- To contact a member of our MS research team, email MCResearchTeam@ccf.org
Refer a Patient
The Mellen Center for Multiple Sclerosis offers direct referral lines to ease the process of making a patient referral.
To refer a patient to the Neurological Institute via phone, please call our dedicated physician referral hotline at 216.445.8455. An intake coordinator will handle your call directly. If you are unable to reach an intake coordinator, please leave a message and they will return your call within the work day (if left before 1 p.m. ET) or the next work day (if left after 1 p.m. ET).
To refer a patient to the Neurological Institute via fax, please download and complete our physician referral form and fax to 216.636.2596.
Stay connected to patients you refer to Cleveland Clinic through online updates and electronic medical records.
Education & Training
In conjunction with Cleveland Clinic Lerner College of Medicine, Mellen Center for Multiple Sclerosis staff have the opportunity to interact in teaching sessions in the neurosciences curriculum, as well as teaching students one-on-one in elective time. We host a neuroimmunology fellowship, have elective rotations for neurology residents and work with medical students regularly. There are also physiatry opportunities for residents and fellows.
Additional education opportunities available through the Mellen Center for Multiple Sclerosis include:
- An annual regional update on multiple sclerosis in late spring/early summer. Watch for an announcement about this program in the spring of each year.
- Electives for physiatry trainees and neurology trainees.
- Medical student rotations as part of the outpatient neurology experience.
- Elective two-week neurology resident outpatient rotation with a variety of experiences including one-on-one bedside teaching with center staff, exposure to rehabilitation procedures such as botox injections for spasticity and intrathecal baclofen pump refills, neuroradiology, occupational therapy, social work and physical therapy.
- A monthly team conference on different topics in multiple sclerosis care which we call “Mellen Center Approaches”. Consensus results of these discussions are posted below for use by all medical professionals who treat patients with multiple sclerosis.
Virtual Grand Rounds
Mellen Center Approaches
To assist other medical professionals involved in treating patients with multiple sclerosis, Mellen Center staff have developed a series of professional "Mellen Center Approaches" fact sheets.
To learn more about Mellen Center for Multiple Sclerosis education opportunities and programs, please contact Alex Rae-Grant, MD at 216.445.2751.
- Frequently Asked Questions about MS
- Multiple Sclerosis: Resources for Caregivers
- Multiple Sclerosis: Glossary of Terms
- How is Multiple Sclerosis Diagnosed?
- Eating Right With MS
- Exercise & Multiple Sclerosis
- Depression & Multiple Sclerosis
- Fatigue in Multiple Sclerosis
- Living with Multiple Sclerosis
- Intimacy and Multiple Sclerosis
- Multiple Sclerosis & Pain
- Impact of Temperature Variation on Multiple Sclerosis
- Impaired Cognition in Multiple Sclerosis
- Talking to Your Teen About Multiple Sclerosis
- Needle Disposal
- Bladder & Bowel Dysfunction