Overview

Overview

Why Choose Lou Ruvo Center for Brain Health?

Cleveland Clinic Lou Ruvo Center for Brain Health provides diagnosis and ongoing treatment for patients with cognitive disorders and support services for family members who care for them, integrating research and education at every level. We take a team approach to neurological care, with physicians, advanced practice clinicians and nurses working in an integrated fashion.

Across our four locations — Cleveland and Lakewood, Ohio; Las Vegas, Nevada and Weston, Florida — our treatment programs are designed to provide excellent care and to respect the dignity of patients and their families. Our collaborative clinical research programs help to advance Cleveland Clinic's groundbreaking clinical trials and offer hope for improving brain health.

An individualized treatment plan is developed for each patient who is treated at the Lou Ruvo Center for Brain Health. The plan is tailored to each patient and may include recommendations for medications, physical exercise, diet, cognitive rehabilitation, psychiatric treatment (when needed), participation in clinical trials and family support.

Many individuals experiencing cognitive decline can benefit from targeted, individualized therapy sessions. At the Lou Ruvo Center for Brain Health, our board certified specialists use cutting-edge technology and customized exercises during one-on-one treatment sessions. Unlike general or orthopedic therapy, our physical (PT), occupational therapy (OT) and speech-language pathology (SLP) programs are specifically tailored to the needs of those experiencing the effects of brain disorders. By incorporating patients’ interests and hobbies and offering socially enriching experiences, we work to increase our patients’ mobility and agility while decreasing fatigue and falls. We also work to improve all aspects of communication and cognition.

Our center’s goal is to leverage research, provide expert care to patients and their caregivers, and empower patients to live as independently as possible.

What We Treat

What We Treat

Learn about the conditions and diseases we treat at Lou Ruvo Center for Brain Health and make an appointment at one of our locations: Nevada, Ohio, or Florida.

Cognitive Disorders

Disease Management

Diagnostics & Testing

Our Doctors

Our Doctors

Appointments

Appointments

In-Person Appointments

To make an appointment with a specialist in Cleveland Clinic’s Neurological Institute, please call toll-free 24 hours, 7 days a week at 866.588.2264.

  • To schedule directly with a provider at Cleveland Clinic in Cleveland, Ohio, please call 866.588.2264 or locally at 216.636.5860
  • To schedule directly with a provider at Cleveland Clinic Florida, please call 866.588.2264 or locally at 954.659.5124
  • To schedule directly with a provider at Cleveland Clinic Nevada, please call 866.588.2264 or locally at 702.483.6000

Locations

Cleveland Clinic's Lou Ruvo Center for Brain Health has locations in Ohio, Florida and Nevada providing diagnosis and ongoing treatment for patients with cognitive disorders and support services for family members who care for them.

Refer a Patient

DrConnect: Online Tool for Referring Physicians

DrConnect is a complimentary online tool for referring physicians that offers secure access to their patients' treatment progress at Cleveland Clinic.

Clinical Trials

Clinical Trials

Clinical trials, the path to better treatment.

Overview

Cleveland Clinic Lou Ruvo Center for Brain Health has come of age in step with an accelerated drive among scientists worldwide to penetrate the secrets of the brain. Since its inception in 2009, the center has taken its place among front-line research institutions racing to find a cure for the spectrum of devastating neurological diseases that plague humankind.

Clinical Trials

What are clinical trials and why are they conducted?

A clinical trial is a research process that is used to test new ways of treating disease. Clinical trials are the only way to test new drugs and advance treatment. We offer a four-prong approach to better understanding of brain health:

  1. Prevention Trials: These trials focus on preventing the onset of brain disease. Typically, they enroll people who are asymptomatic, but who may eventually develop a neurodegenerative disease because of risk factors such as genetics, a positive amyloid brain scan or family history.
  2. Treatment Trials (also known as Clinical Trials): These studies test potential new treatments for individuals with brain disease.
  3. Observational Trials: These studies add to our understanding of how the brain changes over time. They shed light on areas such as disease progression, symptoms and biological markers of disease. They do not test new medications.
  4. Lifestyle Trials: These studies assess the impact of lifestyle choices on brain health, such as a study that evaluates participants engaging in various forms of exercise.

Why should I get involved with clinical trials?

Many get involved because they want to help those suffering from a disease. Others get involved to potentially help themselves by receiving comprehensive assessments and access to the newest medication, which is not yet available to the general public.

The success of finding a new treatment depends on having enough patients participate. Your involvement is the key to finding cures and preventing the onset of brain diseases. You could do something today to make a difference for your family and your community.

How do I participate?

Learn more about current trials at Cleveland Clinic Lou Ruvo Center for Brain Health:

Observational Investigator-led Research

Investigator led studies are clinical studies initiated and managed by a non-pharmaceutical company researchers, like individual investigators, institutions, collaborative study groups or cooperative groups. Cleveland Clinic Lou Ruvo Center for Brain Health engages in many investigator led studies. One is the Professional Athletes Brain Health Study.

    Professional Athletes Brain Health Study Overview
    The effect of repeated head trauma on long term brain health has come under increasing scrutiny as some aging athletes in contact sports are being identified with progressive neurocognitive deficits. Our emphasis is on early identification of cognitive decline and prediction of long-term neurological consequences. Why is it that with similar levels of trauma, some individuals experience a decline in brain health, yet many do not?

    The effect of repeated head trauma on long term brain health has come under increasing scrutiny as some aging athletes in contact sports are being identified with progressive neurocognitive deficits. Our emphasis is on early identification of cognitive decline and prediction of long-term neurological consequences. Why is it that with similar levels of trauma, some individuals experience a decline in brain health, yet many do not?

    The answer has implications for many types head injury in athletics, civilian injury, and injury sustained in military combat.

    Since 2011, more than 820 active and retired professional fighters (boxers, mixed martial arts), professional bull riders, and retired professional football players have been participating in research with the Lou Ruvo Center for Brain Health, the only entity in the country to conduct such a longitudinal study.

    Learn more:

Actively Recruiting: These studies are currently seeking participants

ADNI III

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: CN/MCI/AD, 65-90 years of age
Study Type: Observational (no drug treatment)
Learn more
Purpose: Look at how brain scans and other tests change in individuals with AD; perhaps the most influential study of AD ever conducted


ARISE for MS

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: RIS, 18 years of age and older
Study Type: Interventional (Oral Medication)
Learn more
Purpose:  Can starting treatment promptly delay or prevent the onset of MS in people whose brain scans indicate MS may be developing?


Arise for PSP (Abbvie-PSP)

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: PSP symptoms less than 5 years, ages 40 years of age and older
Study Type: Interventional (Infusion)
Learn more
Purpose:  Can an anti-tau protein infusion halt symptoms in progressive supranuclear palsy (PSP)?


Center for Brain Health Biobank

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Those diagnosed with neurodegenerative disease (e.g. Alzheimer’s disease, Parkinson’s disease), those considered at-risk for neurodegenerative disease and those considered healthy
Study Type: Observational (no drug treatment)
Learn more


COBRE

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Normal, Alzheimer’s; Parkinson’s, 55-90 years of age
Study Type: Observational (no drug treatment)
Learn more
Purpose: A National Institutes of Health (NIH)-funded study to enhance our understanding of aging across diverse populations


Diagnose CTE

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: NFL or college football players; 45-74 years of age
Study Type: Observational (no drug treatment)
Learn more


ENROLL HD

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Huntington’s disease, ages 18 years of age and older
Study Type: Observational (no drug treatment), Prospective registry study for patients with Huntington’s disease
Learn more
Purpose:  A study of people with Huntington’s — an inherited disease — and their family members


Esteem

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Multiple Sclerosis patients 18 years of age and older.  Observational study for patients who are newly initiating treatment with dimethyl fumarate (DMF) under routine clinical care
Study Type: Observational (no drug treatment)
Learn more


Exert

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Mild cognitive impairment (MCI), 65-89 years of age
Study Type: Interventional (Exercise)
Learn more
Purpose: Can exercise slow the progression of memory loss in people with MCI?


Genematch

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Normal asymptomatic 55-75 years of age
Study Type: Registry (database of prospective research participants)
Learn more


Generation I

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Has APOE HZ gene, 60-75 years of age
Study Type: Interventional (Oral Medication/Vaccine)
Purpose:  Can a medication reduce genetic risk of developing memory problems?
Learn more


Healthybrains.org

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: All
Study Type: Registry (database of prospective research participants)
Learn more
Purpose: An online community of individuals interested in receiving a free self-assessment and learning more about their brain health, with the opportunity to receive a monthly newsletter and join a database of potential research volunteers.


Inroads

Location: Las Vegas
Status: Active – Recruiting
Eligibility: Ages 18-70 with XXX MS
Study Type: Interventional (Oral Medication)
Learn more
Purpose: Can a repurposed drug treatment improve walking in individuals with multiple sclerosis (MS)?


Mission AD

Location:  Las Vegas and Cleveland
Status: Active – Recruiting
Eligibility: Mild cognitive impairment (MCI) due to Alzheimer’s, early AD, 50-85 years of age
Study Type: Interventional (Oral Medication)
Learn more
Purpose: Can a pill that reduces amyloid plaque buildup in the brain help individuals with mild memory problems?


MS Path

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Multiple sclerosis (MS), 18 years of age and older; under 18 must have guardian consent and adult present
Study Type: Observational and Biobank blood draw
Learn more


NILO PD

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Parkinson’s disease, 40-79 years of age
Study Type: Interventional (Oral Medication)
Learn more
Purpose:  Can an approved cancer treatment slow symptoms of PD?


Presence/HBEH

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Parkinson’s disease, 40-85 years of age
Study Type: Interventional (Oral Medication)
Learn more
Purpose: Can a new treatment improve memory and thinking in PD?


TANGO

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Mild cognitive impairment (MCI)/Mild Alzheimer’s, 50-80 years of age
Study Type: Interventional (Infusion)
Learn more
Purpose:  Can the first study to use an anti-tau protein infusion slow the decline of cognitive and functional impairment in people with mild cognitive impairment (MCI)?


Recruitment Completed: Enrolled participants are currently completing the study protocol. No more participants are needed.

A4

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Normal Cognition, 65-83 years of age
Study Type: Interventional (Infusion - Solanezumab)
Learn more


Affinity/LINGO

Location: Las Vegas
Status: Active – Recruiting
Eligibility: Relapsing MS; 18-58 years of age
Study Type: Interventional (Infusion)
Learn more
Purpose:  Can we alter the course of MS by rebuilding damaged brain cells (re-myelination)?


ASCLEPIOS

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Relapsing multiple sclerosis (MS); 18-55 years of age
Study Type: Interventional (Injection/Oral)
Learn more


Chords

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Relapsing multiple sclerosis (MS), 18-55 years of age
Study Type: Interventional (Infusion)
Learn more


CREAD II

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: mild cognitive impairment (MCI); 50-85 years of age
Study Type: Interventional (Infusion)
Learn more


Daybreak

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Relapsing multiple sclerosis (MS)
Study Type: Interventional (Oral Medication)
Learn more


Ensemble

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Relapsing multiple sclerosis (MS), 18 years of age and older
Study Type: Interventional (Infusion)
Learn more


Emerge
Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Mild Cognitive Impairment (MCI) or Early Alzheimer’s disease, 50-85 years of age
Study Type: Interventional (Infusion)
Learn more


FLUENT

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Relapsing multiple sclerosis (MS), patients 18 or older
Study Type: Interventional (Oral Medication)
Learn more


LEARN

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Normal cognition, 65-83 years of age, must have been screened for A4 study
Study Type: Observational (no drug treatment)
Learn more


MS BAF

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Secondary Progressive multiple sclerosis (MS), 18-60 years of age
Study Type: Interventional (Oral Medication)
Learn more


MSPT Normative

Location:  Las Vegas and Cleveland
Status: Active – Recruitment Completed
Eligibility: Normal cognition, 10-89 years of age
Study Type: Observational (no drug treatment)
Learn more


Professional Fighter Study

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Active and retired professional fighters
Study Type: Observational (no drug treatment)
Learn more


Rasagiline

Location:  Las Vegas and Cleveland
Status: Recruitment Completed
Eligibility: Mild to moderate Alzheimer’s disease, 50-90 years of age
Study Type: Interventional (Oral Medication)
Learn more


SURE PD3

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Early Parkinson’s; 30 years of age and older
Study Type: Interventional (Oral Medication)
Learn more


TOMMORROW

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Cognitively normal, 65-83 years of age
Study Type: Interventional (Oral Medication)
Learn more


Ultimate II

Location:  Las Vegas
Status: Active – Recruiting
Eligibility: Relapsing multiple sclerosis (MS), 18 to 55 years of age
Study Type: Interventional (Infusion)
Learn more
Purpose: Can an infusion reduce MS attacks by slowing down immune system response?


Veloce

Location:  Las Vegas
Status: Active – Recruitment Completed
Eligibility: Relapsing multiple sclerosis (MS), 18-55 years of age
Study Type: Interventional (Infusion)
Learn more


Research Team

For Medical Professionals

For Medical Professionals

Referrals
Find resources for referring physicians, including physician consults, transfers and a liaison service.

DrConnect
Stay connected to patients you refer to Cleveland Clinic through online updates and electronic medical records.

CME Programs
The Center for Continuing Education is responsible for one of the largest and most diverse CME programs anywhere in the world. We offer live CME courses and free online CME activities.

Fellowships & Residencies
There are 140 staff physicians and scientists and 150 trainees in over 30 post-graduate training programs within the Neurological Institute.

Outcomes
View a summary of our surgical and medical trends and approaches, data on patient volume and outcomes and review new technologies and innovations.

Resources

Resources

Online Services

View portions of your medical record, see test results, renew prescriptions, request appointments and more.

Caregivers who use MyChart can also sign up for the MyChart Caregiver feature.

Events

Ongoing events in Las Vegas, Nevada at Cleveland Clinic Lou Ruvo Center for Brain Health in association with Keep Memory Alive.

Caregiver Support

We offer a number of services for our patients and their families. We view caregiver services as an integral part of our mission. Complementing excellent medical care, our focus on care partners affirms that cognitive disorders impact not just the patient, but everyone involved in their care and support. These programs vary by Cleveland Clinic location.

Families are challenged by supporting a loved one with a neurocognitive or movement disorder. They strive to rise to the occasion, assuming the role of caregiver, partner, advocate or guide to provide support for the patient over the course of the disease.

But who provides care and support for these family caregivers? We recognize that caregivers suffer tremendous stress. While coping with change and loss — in relationships, responsibilities, dreams for the future — caregivers can become overwhelmed, anxious or depressed. From diagnosis throughout the course of the illness, they benefit from guidance and reliable information on where to turn for help.

Self-Assessments

Get a free, online, brain health self-assessment, sign up for a monthly newsletter to receive tips for improving your brain health, or learn how you can participate in research.

Other Resources