Neuromuscular disorders strike 1.5 million Americans annually. Afflicting both young and old – and often those in the prime of life – diseases such as amyotrophic lateral sclerosis, peripheral neuropathy, myasthenia gravis, and myopathies are debilitating, often progressive, and sometimes fatal. Weakness, paralysis, respiratory distress, and intractable pain caused by a nerve disease dramatically alter quality of life for both patients and families.
Cleveland Clinic's Neuromuscular Center specializes in the diagnosis, treatment, and research of these and other neuromuscular disorders. Specialists at the Neuromuscular Center offer comprehensive workups to achieve accurate diagnosis of nerve disease and rely upon state-of-the-art treatment modalities to optimize quality of life. Both inpatients and outpatients benefit from well-orchestrated teamwork by Cleveland Clinic specialists and allied health professionals.
Neurologists, pulmonologists, rheumatologists, pathologists, anesthesiologists, surgeons, and orthopedists join forces with orthotics, physical and occupational therapists, speech pathologists, dieticians, nurse clinicians, and social workers to offer comprehensive, compassionate care for those with neuromuscular disorders.
What We Treat
Diseases and Conditions
Treating neuromuscular diseases such as amyotrophic lateral sclerosis (ALS), peripheral nerve injury, myasthenia gravis and myopathies requires a unique combination of medical expertise and compassion. Specialists in the Neuromuscular Center successfully achieve this blend and strive to apply the latest technology to help patients optimize their quality of life and minimize their disability.
To assist in the accurate diagnosis of these disorders, our specialists rely on diagnostic modalities such as electrodiagnosis (e.g. EMG); autonomic testing; and muscle, nerve and skin biopsies to supplement the history and physical evaluation.
- ALS - The symptoms of ALS, who is affected, how it is treated and the care path for ALS.
- Peripheral Neuropathies - What is peripheral neuropathy? Learn how it is diagnosed and treated in the Neuromuscular Center.
- Myasthenia Gravis - Learn the symptoms and causes and how to diagnosis and treat myasthenia gravis.
- Myopathies - The common myopathies treated in the Neuromuscular Center; learn how they are diagnosed and treated.
Diagnostics and Testing
Minimizing disability and maximizing quality of life depends upon accurate diagnosis and prompt, appropriate treatment of nerve disease and neuromuscular disorders. Yet because symptoms of neuromuscular disorders overlap and mimic those of several diseases, diagnosis can be difficult and often delayed. In addition to a neurological history, examination, and specialized laboratory tests, neuromuscular specialists at Cleveland Clinic rely upon diagnostic investigations such as EMG, the Autonomic Laboratory, Spinal Fluid Analysis, Muscle and Nerve Biopsies and the Peripheral Nerve Injury Program.
- Autonomic Laboratory
- Cutaneous Nerve Laboratory
- EMG Examination
- Skin Biopsy for Small Fiber Sensory Neuropathy
- Spinal Fluid Analysis
- Ultrasound of Peripheral Nerve and Muscle
Make an Appointment
To make an appointment with a Neuromuscular Center staff member please call 216.636.5860 or toll free 866.588.2264.
For our patients’ convenience some services are offered at our Regional Hospitals and Family Health Centers in Northeast Ohio.
If you are a patient and would to make an appointment with Cleveland Clinic's EMG Laboratory, please call 216.636.5860 or toll free, 866.588.2264.
If you are a provider and would like to make an appointment for your patient with Cleveland Clinic's EMG Laboratory, please download our guide below.
Cutaneous Nerve Laboratory
If you are a provider and would like to make an appointment for your patient with Cleveland Clinic’s Cutaneous Nerve Laboratory, please download our guide below.
Please contact our Referring Physician Hotline, available 24 hours a day, 7 days a week, for all your needs, by calling 855.REFER.123 (855.733.3712).
View portions of your medical record, see test results, renew prescriptions, request appointments and more.
Image Copy Request
When requesting a copy of radiology images, please allow a minimum of a 48-hour advance notice for all procedures conducted at any of our imaging centers.
The link below takes you to our secure website where you can request your images electronically.
All CDs will be sent to your home address via UPS.
If you need assistance with the image request process please contact us at 216.444.6651, or toll free 800.223.2273 ext. 46651.
Use of 3,4-Diaminopyridine in Lambert Eaton Syndrome
Compassionate use of orphan drug 3,4-Diaminopyridine (DAP) in Treatment of Lambert Eaton Myasthenic Syndrome (LEMS). The purpose of the drug is to decrease the muscle weakness and other symptoms of Lambert Eaton Syndrome.Traditionally patients are treated with immunosuppressive agents such as Prednisone. The general guidelines for the use of this drug include taking the drug by mouth at increasing dosages until a clinical effect is seen. The duration of the use of this drug will depend upon whether you see benefit from it, and whether any side effects from the drug prevent you from wishing to continue. Additional inclusion and exclusion criteria apply.
If you have any questions or would like more information please contact Fran Greenfield, Clinical Research Coordinator at 216.445.1109.
This study is being conducted by Dr. Kerry Levin at the Cleveland Clinic Neurological Institute.
Section of Amyotrophic Lateral Sclerosis (ALS) and Related Disorders
The mission of the Center for ALS and Related Disorders is to:
- Evaluate and diagnose patients with ALS and other motor neuron diseases (MNDs) in a timely, comprehensive and compassionate fashion.
- Provide excellent and comprehensive clinical care on an ongoing basis to patients with ALS and other MNDs in the multidisciplinary ALS/MND Team Clinic
- Conduct clinical investigations, participate in therapeutic trials and conduct basic research to identify causes and effective treatments of ALS and other MNDs
- Provide ongoing education relevant to ALS and other MNDs to patients and their caregivers, to the multi-disciplinary team, and to health care professionals in the community
ALS Section Creates Solutions to the Challenges of ALS and Other MNDs
Through scientific investigation, specialists in the Section of ALS and Related Disorders continue to probe for the cause of the disease.
Through clinical trials of promising medications, specialists seek potentially effective treatments.
In creating solutions to the many challenges people with ALS face, the ALS Section capitalizes on the interaction and cooperation among the physicians and allied health professionals who are members of the patient’s care-giving team.
ALS Section’s Team of Specialists Offers Comprehensive Care
Although there is no specific treatment for ALS or other MNDs because the cause (or causes) is/are unknown, specialists in the ALS Section are familiar with the disease’s many manifestations. Because the specialists are familiar with both the typical and less typical symptoms, they are adept at distinguishing this disease from similar conditions that can be treated and reversed. Consequently, they are frequently called upon to confirm a diagnosis of ALS and other MNDs. The Section of ALS and Related Disorders specialists diagnose approximately 300 new ALS/MND patients each year from the United States and abroad.
Once the disease is diagnosed, specialists and allied health professionals in the ALS Section offer patients comprehensive treatment in a compassionate setting in the multidisciplinary ALS/MND Team Clinic. Although it is impossible to erase the weakness and progressive muscle paralysis (at present) that accompany ALS and other MNDs, team members strive to maintain, or at times restore, a patient’s muscle function and his or her ability to perform the daily activities of life.
ALS/MND Team Clinic Designated by the ALS Association
Cleveland Clinic’s ALS/MND Team Clinic is one of the first of 34 ALS clinics in the United States to be designated by the Amyotrophic Lateral Sclerosis Association (ALSA).
ALS/MND Team Clinic Specialists
- Acid Maltase Deficiency Association
- ALS (Amyotrophic Lateral Sclerosis) Association
- ALS (Amyotrophic Lateral Sclerosis) Association – Northern Ohio Chapter
- ALS (Amyotrophic Lateral Sclerosis) Survival Guide
- ALS (Amyotrophic Lateral Sclerosis): World Federation of Neurology (WFN)
- Clinical Trials
- Human Gene Mutation Database (HGMD)