At Cleveland Clinic’s Liver Tumor Clinic, we’ve designed our services so that all of the specialists you need – including hepatologists, radiologists, oncologists, liver and transplant surgeons, and specialized nurse coordinators – work together as a team. One call puts you in touch with our multidisciplinary team that works with patients who have benign liver tumors, cancerous liver tumors, cirrhosis of the liver and more in order to develop the appropriate treatment plan, aimed at preserving liver function and quality of life.

This new, “one-stop” clinic improves your treatment by eliminating multiple appointments with different physicians at various locations. Now, all of the doctors you need are assembled here under one roof for you. Not only is this model of care more convenient, but it also allows our physicians to create an individualized treatment plan that’s best for you in less than 30 days.

Mission of the Liver Tumor Clinic

The mission of the Liver Tumor Clinic is to offer state of the art medical care to patients with hepatic tumors through a multidisciplinary team of experienced health care professional leaders in the field of hepatic oncology.

Philanthropic support provides the necessary resources to continue cutting-edge research.

Contact the Liver Tumor Clinic

To reach the Liver Tumor Clinic, please call 216.445.8389 or 800.223.2273 ext. 58389.
Email: livertumorclinic@ccf.org

Our Doctors What We Treat

What We Treat

Tumors Treated

Primary Malignant Tumors

Benign Tumors

Secondary Malignant Tumors

Treatment Options

Treatment options include diverse surgical interventions and locoregional and medical oncological therapies only offered by the most highly specialized centers in the nation


  • Extensive liver resections
  • Two-stage hepatectomy
  • Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure
  • Ex-vivo hepatectomy
  • Liver transplantation

Locoregional Treatments

  • Microwave ablation, cryoablation, electroporation (NanoKnife) and radiofrequency ablation
  • Transcatheter therapies : radioembolization, chemoembolization

Medical Oncology Treatments

  • Diverse systemic chemotherapies and molecular targeted therapies

Minimally Invasive Liver Surgery

The Liver Tumor Clinic offers minimally invasive liver surgery (MIS) via laparoscopic and robotic technology. Since the advent of our MIS liver surgery program in 2006, our team has performed over 200 resections. Diverse types of liver resections and liver sparing interventions such as microwave ablation and radiofrequency ablation are offered to selected patients with the advantage of shorter postoperative hospital length of stay and less surgical pain.



Videos show graphic content. Please watch at your own disgression.



Cleveland Clinic Liver Tumor Clinic Highlights

Since its inception in May of 2009:

  • The multidisciplinary liver tumor clinic has served 646 patients with 530 therapies provided.
  • The time between consults (surgery/hepatology/radiology/oncology) has been reduced 3 fold.
  • A comprehensive liver tumor database has been created.
  • A tumor tissue bank has been created.
  • The number of liver tumor related publications has increased significantly.

Patient Demographics

Mean age (years) 60 +/-11
Gender: Males 65%
Females 35%
Diagnosis: Number:
Hepatocellular carcinoma: 298 (46%)
Colorectal liver metastasis: 81 (13%)
Cholangiocarcinoma: 48 (7%)
Hepatic adenoma: 29 (5%)
Liver hemangioma: 27 (4%)
Liver cyst: 24 (4%)
Metastatic neuroendocrine tumors: 15 (2%)
Others: 124 (19%) (includes liver metastasis from breast CA, pancreas CA, stomach CA, leiomisarcoma, etc)


Surgical: 226
Liver resection: 137
Liver transplantation: 89
Non-surgical: 304
Transarterial chemoembolization
Bland embolization: 22
Transarterial radiotherapy (TARE): 60
Radiofrequency ablation (RFA): 25
Systemic chemotherapy: 45
Sorafenib: 28
Research & Innovations

Research & Innovations

Innovation and treatment discoveries are pivotal within the mission of the Cleveland Clinic Liver Tumor Clinic. Some of these endeavors include:

  • 3-D printing of liver models and computer software to aid surgical treatments of complex liver malignancies
  • Tissue, serum and breath bio-repository for translational research
  • Liver malignancy mice xenograft research platform—to study liver tumors from individual patients fostering personalized medicine in the field of liver oncology

Liver Tumor Clinic Publications


  1. Akyuz M, Yazici P, Dural C, et al. Laparoscopic management of liver metastases from uveal melanoma. Surg Endosc. 2015.
  2. Akyuz M, Yazici P, Yigitbas H, et al. Oncologic results of laparoscopic liver resection for malignant liver tumors. J Surg Oncol. 2015.
  3. Berber E. The first clinical application of planning software for laparoscopic microwave thermosphere ablation of malignant liver tumours. HPB (Oxford). 2015;17(7):632-636.
  4. Berber E. Laparoscopic microwave thermosphere ablation of malignant liver tumors: An initial clinical evaluation. Surg Endosc. 2015.
  5. Dugum M, Hanouneh I, Lopez R, Aucejo F, Eghtesad B, Zein N. Hepatocellular carcinoma in the setting of chronic hepatitis B virus infection: Tumor recurrence and survival rates after liver transplantation. Transplant Proc. 2015;47(6):1939-1944.
  6. Hashimoto K, Miller CM. Liver transplantation for intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 2015;22(2):138-143.
  7. Mi K, Kalady MF, Quintini C, Khorana AA. Integrating systemic and surgical approaches to treating metastatic colorectal cancer. Surg Oncol Clin N Am. 2015;24(1):199-214.
  8. Mohamad B, Bhatt A, Kumaravel A, et al. Xanthogranulomatous cholecystitis mimicking biliary tract cancer. ACG Case Rep J. 2015;3(1):57-59.
  9. Mohamad B, Shah V, Onyshchenko M, et al. Characterization of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis. Hepatol Int. 2015.
  10. Zaidi N, Okoh A, Yigitbas H, Yazici P, Ali N, Berber E. Laparoscopic microwave thermosphere ablation of malignant liver tumors: An analysis of 53 cases. J Surg Oncol. 2015.
  11. Zhang W, Kim R, Quintini C, et al. Prognostic role of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma undergoing liver transplantation. Liver Transpl. 2015;21(1):101-111.
  12. Karagkounis G, Seicean A, Berber E. The impact of laparoscopic approaches on short-term outcomes in patients undergoing liver surgery for metastatic tumors. Surg Laparosc Endosc Percutan Tech. 2015;25(3):229-234.
  13. Kumar AM, Fredman ET, Coppa C, El-Gazzaz G, Aucejo FN, Abdel-Wahab M. Patterns of cancer recurrence in localized resected hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2015;14(3):269-275.