Neuromodulatory Therapy With Responsive Neural Stimulation


Seizure Outcomes in Patients Undergoing RNS Placement at Cleveland Clinic (N = 45)

2021 Responsive Neurostimulation for Epilepsy Outcomes

The graph shows percent seizure reduction (most recent 3-month patient-reported seizure frequency compared with the preresponsive neural stimulation (RNS) baseline seizure frequency) of 45 patients who were implanted with the responsive neurostimulation device at Cleveland Clinic and had > 6 months of accurate seizure reporting.

Two out of 3 (66%) patients have achieved > 50% reduction in their seizure frequency over time.

Location of Responsive Neurostimulation (RNS) Lead Placement

Responsive neural stimulation (RNS) has 2 active leads per device. Above figure highlights Cleveland Clinic's experience with lead placements in various brain regions, outside of the typical mesial temporal regions.

  1. Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, et al. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology. 2020 Sep 1;95(9):e1244-e1256.