Movement Disorders

Deep Brain Stimulation

Change in Motor Aspects of Activities of Daily Living Following Deep Brain Stimulation for Parkinson Disease (N = 35)

2018

DBS = deep brain stimulation, MDS-UPDRS-II = Movement Disorders Society – Unified Parkinson’s Disease Rating Scale Part II

The Movement Disorders Society – Unified Parkinson’s Disease Rating Scale Part II (MDS-UPDRS-II) is a self-administered scale with items covering the motor aspects of activities of daily living including speech, feeding, hygiene, handwriting, tremor, hobbies, mobility, and freezing. Higher numbers reflect worse symptoms. Thirty-five Parkinson disease (PD) patients who underwent deep brain stimulation (DBS) completed the UPDRS-II both before and after surgery (median time to follow-up was 188 days; range, 152–323). The graph shows mean self-reported symptoms ± 2 standard errors of the mean and compares surgical outcome to the expected group change in symptoms over a 1-year period with medical therapy alone.¹ There was a significant improvement in motor-related activity of daily living skills over the treatment period (paired-samples t = 3.6, P < 0.05). The Cleveland Clinic has been designated a Parkinson's Disease Foundation Center of Excellence.

Improvement Following Deep Brain Stimulation Treatment for Parkinson Disease (N = 47)

2018

PGI-I = Patient Global Impression of Improvement

In 2018, 47 Parkinson Disease patients completed the Patient Global Impression of Improvement (PGI-I) questionnaire after DBS. Median time to follow-up was 98 days (range, 35–359). At follow-up, 83% rated their condition as improved, compared with their condition before surgery.

Improvement Following Deep Brain Stimulation for Essential Tremor (N = 38)

2018

PGI-I = Patient Global Impression of Improvement

In 2018, 38 essential tremor patients completed the PGI-I questionnaire after DBS. Median duration of follow-up was 74 days (range, 34–352). At follow-up, 76% percent of patients rated their condition as improved, and none worsened, compared with their condition before surgery.

References
  1. Holden SK, Finseth T, Sillau SH, Berman BD. Progression of MDS-UPDRS scores over five years in de novo Parkinson disease from the Parkinson’s Progression Markers Initiative Cohort. Mov Disord Clin Pract. 2018 Jan-Feb;5(1):47-53.