Cognitive Disorders

Depressive Symptoms

Cleveland Clinic’s Lou Ruvo Center for Brain Health cares for patients with a variety of neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer disease (AD), Lewy body dementia (LBD), and frontotemporal dementia (FTD). Patients are evaluated for depressive symptoms, as measured by the Patient Health Questionnaire (PHQ-9), and health-related quality of life, as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS-10®).

Change in Depressive Symptoms in Patients With Cognitive Disorders (N = 407)

2021 – 2022

AD = Alzheimer disease, FTD = frontotemporal dementia, LBD = Lewy body dementia, MCI = mild cognitive impairment

Fluctuations in 2022 volumes are a result of significant changes to the number of patients treated, which can be directly attributed to the COVID-19 pandemic.

Many patients with neurocognitive disease have comorbid conditions such as depression. Depression is most common in FTD but affects about one-third of patients with AD and MCI. Depression is a treatable complication of cognitive decline, and depressive symptoms remained stable or improved in most patients. Data include all patients with at least moderate depressive symptoms, as defined by a PHQ-9 score ≥ 10, at their initial visit. Clinically meaningful change was defined as a total point change of 5 or more.¹ Median interval between assessments was 226 days (range, 1-470 days).

  1. Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care. 2004 Dec;42(12):1194-1201.