Epilepsy

Pediatric Epilepsy

Pediatric Epilepsy: Effect of Treatment on Mood

2009 – 2021

Medical Patients CES-DC (N = 237)

A total of 237 medically treated pediatric epilepsy patients seen from 2009 through 2021 had 2 Center for Epidemiological Studies-Depression scale (CES-DC) scores at least 180 days apart. Of these, 28% improved, 39% remained stable, and 32% worsened. Clinically meaningful change was defined as a total point change of ≥ 5 based on one-half the standard deviation of the baseline score.¹ Median time between questionnaire completions was 1058 days (range, 182-3891).

Surgical Patients CES-DC (N = 78)

A total of 78 surgically treated pediatric epilepsy patients seen from 2009 through 2021 had 2 Center for Epidemiological Studies-Depression scale (CES-DC) scores at least 180 days apart. Of these, 46% improved, 30% remained stable, and 24% worsened. Clinically meaningful change was defined as a total point change of ≥ 5 based on one-half the standard deviation of the baseline score.¹ Median time between questionnaire completions was 443.5 days (range, 181-2645).

Pediatric Epilepsy: Effect of Treatment on Quality of Life

2008 – 2021

Medical Patients (N = 689)

A total of 689 medically treated pediatric epilepsy patients seen from 2008 through 2021 had 2 Child’s Overall QOL scores at least 180 days apart. Of these, 30% improved, 46% remained stable, and 24% worsened. Clinically meaningful change was defined as a total point change of ≥ 1 based on one-half the standard deviation of the baseline score.¹ Median time between questionnaire completions was 1372 days (range, 181-3959).

Surgical Patients (N = 242)

A total of 242 surgically treated pediatric epilepsy patients seen from 2008 through 2021 had 2 Child’s Overall QOL scores at least 180 days apart. Of these, 62% improved, 27% remained stable, and 10% worsened. Clinically meaningful change was defined as a total point change of ≥ 1 based on one-half the standard deviation of the baseline score.¹ Median time between questionnaire completions was 537.5 days (range, 184-3552).

References
  1. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003 May;41(5):582-592.