Epilepsy

Pediatric Epilepsy

Pediatric Epilepsy: Effect of Treatment on Mood

2009 – 2023

Medical Patients CES-DC (N = 256)

A total of 256 medically treated pediatric epilepsy patients seen from 2009 through 2023 had two Center for Epidemiological Studies-Depression scale (CES-DC) scores at least 180 days apart. Of these, 32% improved, 33% remained stable, and 35% worsened. Median time between questionnaire completions was 1032.5 days (range, 182-4242 days).

Surgical Patients CES-DC (N = 88)

A total of 88 surgically treated pediatric epilepsy patients seen from 2009 through 2023 had two Center for Epidemiological Studies-Depression scale (CES-DC) scores at least 180 days apart. Of these, 44% improved, 33% remained stable, and 23% worsened. Median time between questionnaire completions was 501 days (range, 181-3724 days).

Clinically meaningful change was defined as a total point change of ≥ 5 based on one-half the standard deviation of the baseline score.¹

Pediatric Epilepsy: Effect of Treatment on Quality of Life

2008 – 2023

Medical Patients (N = 578)

A total of 578 medically treated pediatric epilepsy patients seen from 2008 through 2023 had two Child’s Overall Quality of Life ( QOL) scores at least 180 days apart. Of these, 31% improved, 44% remained stable, and 25% worsened. Clinically meaningful change was defined as a total point change of ≥ 1 based on one-half the standard deviation of the baseline score.¹ Median time between questionnaire completions was 1391 days (range, 182-3959 days).

Surgical Patients (N = 246)

A total of 246 surgically treated pediatric epilepsy patients seen from 2008 through 2023 had two Child’s Overall QOL scores at least 180 days apart. Of these, 62% improved, 27% remained stable, and 11% worsened. Clinically meaningful change was defined as a total point change of ≥ 1 based on one-half the standard deviation of the baseline score.¹ Median time between questionnaire completions was 546 days (range, 184-3552 days).

References
  1. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003 May;41(5):582-592.