Epilepsy

Adult Epilepsy: Effect of Treatment on Global Mental Health

Change in Global Mental Health in Adult Epilepsy Patients

2014 – 2022

Medical Patients (N = 3257)

6893 medically treated patients had at least 2 visits with PROMIS-10 Mental Health data available for analysis. Among those patients whose baseline PROMIS-10 Mental Health score ≤ 45 (N = 3257), 33.7% (N = 1099) showed improvement, 51.2% (N = 1669) remained stable, and 15% (N = 489) worsened. Median duration of follow-up was 1282 days (range, 180-2976 days).

Surgical Patients (N = 129)

212 surgical patients had a presurgery visit and postsurgery visit with PROMIS-10 Mental Health data available for analysis. Among those patients whose baseline PROMIS-10 Mental Health score ≤ 45 (N = 129), 36.4% (N = 47) showed improvement, 45% (N = 58) remained stable, and 18.6% (N = 24) worsened. Median duration of follow-up was 799 days (range, 188-2570 days). Clinically meaningful change was defined as a 5-point change in T-score, based on one-half the standard deviation.²

References
  1. Cella D, Yount S, Rothrock N, Gershon R, Cook K, Reeve B, Ader D, Fries JF, Bruce B, Rose M, PROMIS Cooperative Group. The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years. Med Care. 2007 May;45(5 Suppl 1):S3–S11.