Epilepsy

Adult Epilepsy: Effect of Treatment on Global Mental Health

Change in Global Mental Health in Adult Epilepsy Patients

2013 – 2021

Medical Patients (N = 3170)

7722 medically treated patients had at least 2 visits with PROMIS-10 Mental Health data available for analysis. Among those patients whose baseline PROMIS-10 Mental Health score ≤ 45 (N = 3170), 31.6% (N = 1001) showed improvement, 54% (N = 1713) remained stable, and 14.4% (N = 456) worsened. Median duration of follow-up was 1074 days (range, 180-2608).

Surgical Patients (N = 93)

163 surgical patients had a presurgery visit and postsurgery visit with PROMIS-10 Mental Health data available for analysis. Among those patients whose baseline PROMIS-10 Mental Health score ≤ 45 (N = 93), 38.7% (N = 36) showed improvement, 43% (N = 40) remained stable, and 18.3% (N = 17) worsened. Median duration of follow-up was 770 days (range, 188-1876). Clinically meaningful change was defined as a 5-point change in T-score, based on one-half the standard deviation.²

References
  1. Cella D, Yount S, Rothrock N, Gershon R, Cook K, Reeve B, Ader D, Fries JF, Bruce B, Rose M, PROMIS Cooperative Group. The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years. Med Care. 2007 May;45(5 Suppl 1):S3–S11.