Epilepsy

Adult Epilepsy: Effect of Treatment on Global Mental Health

Change in Global Mental Health in Adult Epilepsy Patients

2014 – 2023

Medical Patients (N = 7864)

7864 medically treated patients had at least 2 visits with PROMIS-10 Mental Health data available for analysis. Among those patients whose baseline PROMIS-10 Mental Health score ≤ 45 (N = 3761), 35% (N = 1318) showed improvement, 50.8% (N = 1909) remained stable, and 14.2% (N = 534) worsened.

Median duration of follow-up was 1336 days (range, 180-3347 days).

Surgical Patients (N = 291)

291 surgical patients had a pre-surgery visit and post-surgery visit with PROMIS-10 Mental Health data available for analysis. Among those patients whose baseline PROMIS-10 Mental Health score ≤ 45 (N = 177), 39% (N = 69) showed improvement, 48% (N = 85) remained stable, and 13% (N = 23) worsened.

Median duration of follow-up was 1135 days (range, 188-2625 days).

Clinically meaningful change was defined as a 5-point change in T-score, based on one-half the standard deviation.²

References
  1. Cella D, Yount S, Rothrock N, Gershon R, Cook K, Reeve B, Ader D, Fries JF, Bruce B, Rose M, PROMIS Cooperative Group. The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years. Med Care. 2007 May;45(5 Suppl 1):S3–S11.