Epilepsy

Adult Epilepsy: Effect of Treatment on Quality of Life

Improvement in Quality of Life in Medically Treated Adult Epilepsy Patients (N = 4631)

2007 – 2023

QOLIE-10 = Quality of Life in Epilepsy questionnaire

Note: Lower score means improved quality of life.

In medically treated patients, the mean QOLIE-10 score changed from 22 at initial visit to 19.6 at last follow-up (p < 0.001). The median (Q1, Q2) was 20 (15, 28) at initial visit and 18 (14, 24) at follow-up.

N = patients with at least 6 months of follow-up.

Mean duration of follow-up was 70.9 months.

The standard box plots reflect the median and the 25th and 75th quartiles.

Improvement in Quality of Life in Surgically Treated Adult Epilepsy Patients (N = 745)

2007 – 2023

QOLIE-10 = Quality of Life in Epilepsy questionnaire

Note: Lower score means improved quality of life.

In surgically treated patients, the mean QOLIE-10 score changed from 27.9 at initial visit to 22.2 at last follow-up (p < 0.001). The median (Q1, Q2) was 28 (21, 35) at initial visit and 20 (16, 28) at follow-up.

N = patients with at least 6 months of follow-up.

Mean duration of follow-up was 56 months.

The standard box plots reflect the median and the 25th and 75th quartiles.

Clinically Meaningful Improvement in Quality of Life

2007 – 2023

Patients Achieving Clinically Meaningful Improvement

Medically treated patients

(N = 4631)

47.7%

Surgically treated patients

(N = 745)

63.8%

Clinically meaningful improvement in quality of life is defined as a drop of at least 10% in the baseline QOLIE-10 Score.¹

References
  1. Cramer JA, Perrine K, Devinsky O, et al. A Brief Questionnaire to Screen for Quality of Life in Epilepsy The QOLIE-10. Epilepsia 1996;37(6):577-582