Epilepsy

Adult Epilepsy: Effect of Treatment on Quality of Life

Successful epilepsy treatment should translate into a better quality of life. Patients’ quality of life is assessed at every outpatient clinic visit using the Quality of Life in Epilepsy questionnaire (QOLIE-10), a 10-item, validated, patient-completed questionnaire covering general and epilepsy-specific domains: epilepsy effects (memory, physical and mental effects of medication), mental health (energy, depression, overall quality of life), and role functioning (seizure worry, work, driving, social limits). Lower scores reflect a better quality of life. QOLIE-10 scores improved in both the medical and surgical groups.

Improvement in Quality of Life in Medically Treated Adult Epilepsy Patients (N = 5434)

2008– 2018

In medically treated patients, the mean QOLIE-10 score improved from 22.1 at initial visit to 20.7 at last follow-up (P < 0.001). N = patients with at least 6 months of follow-up. Mean duration of follow-up was 43.4 months. The standard box plots reflect the median and the 25th and 75th quartiles.

Improvement in Quality of Life in Surgically Treated Adult Epilepsy Patients (N = 494)

2008 – 2018

In surgically treated patients, the mean QOLIE-10 score improved from 27.7 at initial visit to 22.7 at last follow-up (P < 0.001). N = patients with at least 6 months of follow-up. Mean duration of follow-up was 37 months. The standard box plots reflect the median and the 25th and 75th quartiles.

Clinically Meaningful Improvement in Quality of Life

2009 – 2018

Patients Achieving Clinically Meaningful Improvement
Medically treated patients (N = 5434)41%
Surgically treated patients (N = 494)59%

Clinically meaningful improvement in quality of life is defined as a drop of at least 10% in the baseline QOLIE-10 Score. (References 1-3)

References
  1. Cramer JA, Perrine K, Devinsky O, Meador K. A brief questionnaire to screen for quality of life in epilepsy: the QOLIE-10. Epilepsia. 1996 Jun;37(6):577-582.
  2. Cramer JA, Arrigo C, Van Hammée G, Gauer LJ, Cereghino JJ. Effect of levetiracetam on epilepsy-related quality of life. N132 Study Group. Epilepsia. 2000 Jul;41(7):868-874.
  3. Jehi L, Tesar G, Obuchowski N, Novak E, Najm I. Quality of life in 1931 adult patients with epilepsy: seizures do not tell the whole story. Epilepsy Behav. 2011 Dec;22(4):723-727.