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James Cook, MD, PhD

James Cook, MD, PhD
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Department Clinical Pathology
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon No
Locations Specialties & Treatments

Specialty in Diseases & Conditions

  • Dendritic Cell Related Histiocytic Sarcomas
  • Erdheim-Chester Disease (ECD)
  • Follicular Dendritic Cell Sarcoma (FDCS)
  • Histiocytic Disorders
  • IgM Monoclonal Gammopathy
  • Interdigitating Dendritic Cell Sarcoma
  • Langerhans Cell Histiocytosis (LCH)
  • Lymphoplasmacytic Lymphoma
  • Macrophage-Related Histiocytic Sarcomas
  • Pediatric Rare Cancer and Blood Disease Program
  • Rare Cancer and Blood Disease Program
  • Rosai-Dorfman Disease (RDD)
  • Thymic Cancer
  • Waldenstrom’s Macroglobulinemia
View all 14 Specialties +


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About James Cook, MD, PhD

James R. Cook, M.D., Ph.D., is a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine.  He serves as Section Head of Hematopathology in the Department of Laboratory Medicine.  Dr. Cook's clinical interests focus on diagnostic hematopathology and molecular diagnostics.

His research interests include diagnostic and prognostic markers in non-Hodgkin lymphoma and plasma cell disorders, and molecular diagnosis of leukemia and lymphoma.  He participates in numerous multi-institutional research efforts including the Lymphoma and Leukemia Molecular Profiling Project (LLMPP) and the Lymphoma Translational Medicine Committee for SWOG.  He regularly serves as faculty for post-graduate educational courses at national and international meetings.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - University of Pittsburgh School of Medicine
Pittsburgh, PA

Residency - Barnes Jewish Hospital
Anatomic Pathology
St. Louis, MO

Graduate School - Washington University School of Medicine
St. Louis, MO

Medical Education - Washington University School of Medicine
St. Louis, MO

Undergraduate - Pennsylvania State University
University Park, PA

Professional Highlights

  • President, Society for Hematopathology, 2020-2022
  • Chair, Association for Molecular Pathology Hematopathology Subdivision, 2011-2012
  • Member of Lymphoma Translational Medicine Committee, Southwest Oncology Group


  • Pathology - Hematology
  • Pathology - Anatomic Pathology

Specialty Interests


Awards & Honors

  • Pathologist-in-Training Award, Society for Hematopathology, 2003
  • John Beach Hazard Distinguished Teacher Award, Institute of Pathology and Laboratory Medicine, 2005


  • Society for Hematopathology
  • United States and Canadian Academy of Pathology
  • American Society for Clinical Pathology
  • Association for Molecular Pathology
  • College of American Pathologists
Research & Publications

Research & Publications

See publications for James Cook, MD, PhD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/22/2024, Dr. Cook has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

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