National Management Center

The Center for Pediatric Rheumatology at Cleveland Clinic Children’s is dedicated to providing cutting-edge, patient-centered care to children with a broad range of rheumatologic conditions. Our center is a well recognized for excellence in the diagnosis and management of a variety of inflammatory and autoimmune disorders that affect the joints, muscles, and connective tissue. Our physicians, surgeons and scientists are known nationally and internationally for their leadership, innovation and superior patient care outcomes.

  • We are a regional, national, and international referral center for families seeking second opinion services for pediatric rheumatologic conditions, including juvenile arthritis, vasculitis and childhood autoinflammatory diseases.
  • Our facility offers patients the opportunity to participate in numerous state-of-the-art clinical trials for juvenile arthritis and vasculitis.
  • The members of the Center are dedicated to working closely with patients and coordinating efforts with referring providers to ensure families receive world-class care close to home.

Multidisciplinary Team

Through our multidisciplinary approach and the expertise of our pediatric team members, Cleveland Clinic is able to offer high quality care in a number of specialty areas. Our team of expert doctors coordinates their efforts with a variety of pediatric subspecialist colleagues to provide world-class, comprehensive care to patients and families. The Pediatric Rheumatology team has close collaboration with the following subspecialists at Cleveland Clinic Children’s Hospital:

Working closely with our colleagues in adult orthopaedic and rheumatology programs, we can also provide seamless transition of care for young adults with childhood-onset rheumatic conditions.

International Access

The Center for Pediatric Rheumatology is internationally recognized for its expertise in evaluation of rare or complex rheumatologic conditions. In addition to providing pediatric patients with quality family-centered care we also offer rheumatology care for children and adolescents outside of the country.

Through the Global Patient Services Department, our International Center regularly arranges visas, travel, and accommodations for families who require extensive out-patient evaluations and/or in-patient management. Translators are also available for 28 languages for the convenience of all of our patients. The International Center may be reached at +1.844.330.0842

Long distance consultations are also available through MyConsult. Our physicians are able to review case histories from other states or overseas at the request of patients or individual physician generalists and specialists.

What We Treat

What We Treat

Rheumatic and autoimmune diseases are disorders which can affect any part of the body including the joints, muscles, connective tissues, and soft tissues around the joints and bones. We evaluate and treat children with a number of rheumatic and immunological diseases including:


Autoinflammatory Syndromes

  • Blau’s syndrome
  • Chronic recurrent multifocal osteomyelitis (CRMO)
  • Deficiency of interleukin-1 receptor antagonist (DIRA)
  • Familial Cold Autoinflammatory syndrome (FCAS)
  • Familial Mediterranean Fever Syndrome
  • Hyper-Immunoglobulin D syndrome
  • Majeed’s Syndrome
  • Mevalonate kinase deficiency
  • Muckle-Wells Syndrome
  • Neonatal onset multisystem inflammatory disease (NOMID), Chronic Inflammatory Neonatal Arthritis (CINCA)
  • NLRP12- associated autoinflammatory disorders
  • Periodic Fever Aphthous Stomatitis and Adenopathy Syndrome (PFAPA)
  • Periodic Fever Syndrome
  • Recurrent fever syndromes
  • Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO)
  • TNF-receptor associated periodic syndrome (TRAPS)

Connective Tissue Disease


  • Acute or chronic limp
  • Autoimmune disease
  • Epislceritis
  • Growing Pains
  • Hypermobility arthralgia
  • Scleritis
  • Sjögren’s Syndrome
  • Uveitis


The Center for Pediatric Rheumatology has established comprehensive programs for the diagnosis and treatment of children and adolescents who are living with a variety of rheumatologic disorders. Learn more about each of these programs and the patients they serve.

Childhood Autoinflammatory Diseases

A collaboration with pediatric physician partners in Infectious Disease, this program is staffed by experts in diagnosing and managing various types of childhood autoinflammatory diseases in children and young adults, including:

  • Blau’s syndrome
  • Cryopyrin-Associated Periodic Syndrome (CAPS)
  • Familial Cold Autoinflammatory Syndrome (FCAS)
  • Familial Mediterranean fever (FMF)
  • Hyperimmunoglobulin D Syndrome (HIDS)
  • Muckle-Wells Syndrome (MWS)
  • Periodic Fever, Aphthous stomatitis, Pharyngitis &Adenopathy syndrome (PFAPA)
  • Periodic or recurrent fever syndromes
  • TNF Receptor Associated Periodic Syndrome (TRAPS)

In addition our collaboration with colleagues in pediatric otolaryngology has received an excellent response when tonsillectomies are performed on patients with autoinflammatory diseases.

Once a visit is completed, our physicians will actively collaborate with the patient's local care team to support ongoing care. Patients are also provided with the option of participating in a number of clinical, therapeutic and translation research studies being conducted at our center.

Juvenile Arthritis

The Center for Pediatric Rheumatology currently cares for more than 300 children with some form of chronic arthritis. Our treatment approach is driven by national guidelines yet individualized to meet the needs and expectations of our patients and their families.

Our program offers unique opportunities for patients and families, including:

  • Research. Our researchers are conducting multiple studies on children with JIA including collaborative studies with the NIH to identify genetic markers associated with JIA, cutting-edge therapeutic trials for new biologics in JIA, and the financial impact of JIA on the healthcare system and families.
  • Shared Medical Appointments. Our patients and families are invited to participate in Shared Medical Appointments where 6-8 children with JIA and their family members meet with our nurse practitioner every 3 months for an educational session and routine check-up.
    The SMA visit consists of a 20 minute presentation on various subjects related to your child’s arthritis, followed by a private examination to address each child’s needs. For more information about SMAs please contact us at 216.445.1099.
  • Pediatric Infusion Suites. Patients requiring infusible medications like Remicade®, Orencia®, or Actemra® are able to receive their infusions at the Children’s Hospital’s pediatric infusion center on main campus or at satellite locations in Avon (Richard E. Jacobs Health Center) or Twinsburg.

To discover treatment options available for your child, download our free parent’s guide to juvenile arthritis.


Patients coming for a visit with our pediatric rheumatologists have access to ENT doctors, ophthalmologists, neurologists, radiologists, cardiologists, pulmonologists, and vascular surgeons with extensive experience in the evaluation and management of children with vasculitis. We also work closely with internationally-known experts in the Center for Vasculitis Care and Research also located at Cleveland Clinic.

Upon completion of the visit, our physicians actively collaborate with a patient's local care teams to support ongoing care. Patients are also provided with the option of participating in a number of clinical, therapeutic and translation research studies being conducted at our center.

To schedule an appointment with the rheumatology team for one of these programs, request an appointment online or call us at 216.444.9000 or 866.275.7496.