Doctors at Cleveland Clinic perform a Pulmonary Thromboendarterectomy
Doctors at Cleveland Clinic perform a Pulmonary Thromboendarterectomy

At the Cleveland Clinic Respiratory Institute, our Pulmonary Hypertension Program is one of the nation's largest and most comprehensive treatment programs for patients with pulmonary hypertension. Our commitment is to provide patients with the best medical advice and to evaluate you in a timely manner with compassion and courtesy.

Patient Care–Patients First

For nearly 20 years, we have been caring for patients with all forms of pulmonary hypertension, including idiopathic pulmonary arterial hypertension (PAH), chronic thromboembolic pulmonary hypertension, portopulmonary hypertension and pulmonary hypertension associated with connective tissue diseases.

Our physicians and nurses have special expertise and interest in pulmonary hypertension, and are dedicated to the evaluation and care of patients with pulmonary hypertension. Teams are comprised of pulmonary and critical care physicians, advanced practice nurses, research nurse coordinators and research fellows. We also collaborate closely with the departments of cardiovascular medicine, cardiovascular imaging, cardiothoracic surgery, and lung transplantation as well as specialists in hepatology, liver transplantation, sleep medicine and rheumatology. As a result, our patients receive the most comprehensive, timely care as well as benefit from cutting-edge research and the best treatment options available for pulmonary hypertension.

Our HHT Center of Excellence has expertise in evaluating patients who have hereditary hemorrhagic telangiectasia (HHT). Among the numerous manifestations of hereditary hemorrhagic telangiectasia (HHT), pulmonary arteriovenous malformations contribute significantly to morbidity and mortality by causing hypoxemia and increasing the risk of stroke, brain abscess, and hemoptysis. Our physicians have expertise in evaluating patients who have pulmonary arteriovenous malformations and in minimally invasive techniques to embolize these lesions.

As part of our commitment to excellence in patient care, research and education, we bring together local, national and international experts during our Pulmonary Hypertension Symposium. This annual event provides patients and medical professionals with a unique opportunity to learn about the most recent advancements in the diagnosis and treatment of pulmonary hypertension.

View Our Treatment Outcomes

Our Outcomes offer detailed information and data to help patients and their physicians make informed decisions about treatment for a wide-range of respiratory issues.

Health Information

Health Information

Pulmonary hypertension (PH) is a group of diseases characterized by high pulmonary artery pressures and pulmonary vascular resistance. Pulmonary hypertension can be idiopathic (primary) or secondary to an identifiable underlying pulmonary, cardiac or systemic disease.

Idiopathic pulmonary arterial hypertension (IPAH), previously known as primary pulmonary hypertension, is a progressive disease that affects predominantly young individuals, is more common in females, and traditionally had an average survival rate of two to three years from the time of diagnosis. Thanks to the availability of targeted or advanced therapies for pulmonary hypertension, this survival rate has improved in recent years.

Types of Pulmonary Hypertension

  • PH originating at the pulmonary arteries (i.e., pulmonary arterial hypertension or PAH)
  • PH originating in the heart (i.e., pulmonary venous hypertension or PVH)
  • PH originating in the lung tissue or due to poor oxygenation
  • PH due to clots in the pulmonary arteries (i.e., chronic thromboembolic pulmonary hypertension or CTEPH)
  • PH due to unclear mechanisms (i.e., idiopathic pulmonary hypertension)

Causes of Pulmonary Hypertension

Pulmonary hypertension is associated with several conditions including:

  • Unknown causes (i.e., idiopathic)
  • Scleroderma, lupus or other inflammatory diseases
  • Heart, lung, liver, kidney and blood diseases
  • Blood clots - this condition is called chronic thromboembolic pulmonary hypertension (CTEPH)

Treatments for Pulmonary Hypertension

At Cleveland Clinic, our patients are on various advanced pulmonary hypertension therapies, such as intravenous epoprostenol (Flolan and Veletri), intravenous and inhaled treprostinil (Remodulin and Tyvaso), oral bosentan and ambrisentan (Tracleer and Letairis), oral sildenafil and tadalafil (Revatio and Adcirca). Many patients are on combination therapy.

The treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH) is a complex surgery called pulmonary thromboendarterectomy, which can potentially cure this disease. Cleveland Clinic is one of the few centers in the country with expertise in this procedure.

More Information from our Health Library

Learn more about symptoms, causes, diagnostic tests and treatments for pulmonary hypertension and other pulmonary vascular diseases in our Health Library.



Appointments & Locations

Appointments & Locations

Make an Appointment

To make an appointment with a Cleveland Clinic pulmonary hypertension specialist, call 216.636.5327 or toll-free 1.800.223.2273 (ext. 65327).


Research & Clinical Trials

Research & Clinical Trials

We have several ongoing investigator-initiated research projects aimed at understanding the pathophysiology of pulmonary hypertension (PH).

Pulmonary Hypertension Clinical Trials

SOUTHPAW: A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF)

United Therapeutics is sponsoring this study to assess the effect of oral treprostinil compared with placebo on change in exercise capacity as measured by change in 6-Minute Walk Distance (6MWD) from Baseline to Week 24 in subjects with PH associated with HFpEF. This study is recruiting patients that have WHO Group 2 Pulmonary Hypertension associated with left heart failure, a Six Minute Walk Test of ≥ 150 meters, and an ECHO with an LVEF value of LVEF ≥45%. Patients are excluded if they are currently taking PAH approved therapies, or have a recent history of hospitalization for a cardiopulmonary indication, and/or a Myocardial Infarction of Cardiac Resynchronization.


Mary Beukemann | 216.444.2140
Bryan Poynter | 216.445.1630

INTREPID A Phase 3 Open-Label, Multicenter Study to Evaluate the Long-term Safety and Tolerability of Inhaled LIQ861 (Treprostinil) in Pulmonary Arterial Hypertension (WHO Group 1) Patients

Liquidia is the sponsor of this study that will be evaluating the long-term safety and tolerability of LIQ861 in Patients with PAH. This study will also be evaluating the comparative bioavailability of treprostinil between two formulations of inhaled therapy. This study is enrolling patients 18 years or older diagnosed with WHO Group 1 Pulmonary Arterial Hypertension. Patients can be currently on a stable dose of approved inhaled therapy (Tyvaso), or no more than two PAH approved oral therapies. Patients taking any oral, IV or SubQ prostacyclin analogues or agonists other than Tyvaso will be excluded.


Mary Beukemann | 216.444.2140
Bryan Poynter | 216.445.1630

Pulmonary Arterial Hypertension Improvement with Nutrition and Exercise (PHINE) - A Randomized Controlled Trial

The National Institute of Health is funding this study to assess the effect of diet and exercise on metabolism and its role in pulmonary hypertension. This is a 12 week Diet and Exercise study that has 5 days a week of exercise training and 1 day a week of diet counseling. Recruiting patients that have WHO Group 1 Pulmonary Arterial Hypertension including idiopathic, heritable, drugs and toxin induced, and PAH associated with connective tissue disease, HIV infection and congenital heart disease on 1 or more PAH targeted therapy with a stable dose for 1 month. Patients are excluded if they have Diabetes, CTEPH, Portal Hypertension, and syncope within the previous 3 months.


Chazity Bush | Office: 216.444.3702 | Cell: 216.385.4694
Celia Melillo | 216.445.3763

A Study of the Efficacy and Safety of Bardoxolone Methyl in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

Sponsored by Reata Pharmaceuticals the study’s main objective is to assess the efficacy and safety of bardoxolone methyl relative to placebo in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH).

ELIGIBILITY: Symptomatic pulmonary hypertension WHO/NYHA FC class II and III; WHO Group I PAH associated with connective tissue disease; Had a diagnostic right heart catheterization performed and documented within 36 months prior to Day 1 that confirmed a diagnosis of PAH according to all the following criteria: a. Mean pulmonary artery pressure ≥ 25 mm Hg (at rest); b. Pulmonary capillary wedge pressure (PCWP) ≤ 15 mm Hg; c. Pulmonary vascular resistance > 240 dyn•sec/cm5 or > 3 mm Hg/liter (L)/minute.


STUDY COORDINATOR: Mary Beukemann | 216.444.2140

SPHERE; Uptravi® (SelexiPag): tHe UsErs dRug rEgistry

Describes the demographics, disease characteristics, dosing regiments and titration schemes and the clinical course of patients treated with Uptravi, including any transition processes from other PAH specific therapies to Uptravi and from Uptravi to other prostanoids. The study is looking for patients with PAH who either initiating Uptravi or have been receiving treatment with Uptravi and have a documented titration regimen.


STUDY COORDINATOR: Mary Beukemann | 216.444.2140

Pulmonary Hypertension Research Registry

The Pulmonary Hypertension Research Registry is a collection of patients’ clinical and demographic data be used for future research. The purpose of this registry is to develop a list of prospective participants with Pulmonary Hypertension who are interested in learning about future research opportunities. In addition to being part of the registry, participants will receive quarterly newsletters including information about recent research findings in pulmonary hypertension, currently enrolling and upcoming studies, and more.


STUDY COORDINATOR: Mary Beukemann | 216.444.2140

A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Subjects with Pulmonary Hypertension due to Parenchymal Lung Disease (RIN-PH-201)

The purpose of this study is to evaluate the safety and efficacy of inhaled treprostinil in subjects with pre-capillary pulmonary hypertension (PH) associated with interstitial lung disease (ILD) including combined pulmonary fibrosis and emphysema (CPFE). Inclusion criteria include WHO Group 3 PH based on CT imaging that demonstrates evidence of diffuse parenchymal lung disease, baseline 6MWD ≥ 100 meters and a right heart catheterization performed within 1 year prior to randomization with the specific documented parameters. Exclusion criteria include subject receipt of any PAH approved therapy including: ERA, PDE5, or soluble guanylate cyclase.


STUDY COORDINATOR: Mary Beukemann | 216.444.2140

For Medical Professionals

For Medical Professionals


We offer elective, two-to-four-week rotations that include clinical or research experience for residents, pulmonary fellows, cardiology fellows and community physicians, who want to learn more about pulmonary hypertension, as well as pulmonary hypertension experiences for allied health professionals. For more information, visit the Center for Advanced Skills Training.


Disease Management Project

Cleveland Clinic publishes an online medical reference, the Disease Management Project, which provides nationally-established treatment guidelines for the most common diseases and conditions.
View an overview of treatment guidelines for:

Recommended Readings

View helpful publications written by Cleveland Clinic Respiratory Institute physicians on the topic of pulmonary hypertension.