Cleveland Clinic lung cancer specialists are nationally recognized for diagnosing and treating lung and chest cancers. Our team provides the newest medical and surgical treatment options available for lung cancer today with survival rates of patients consistently five to 20 percent higher than the national average.

Lung Nodule Clinic

Any patient with a lung nodule discovered by their physician on CT imaging or chest x-ray can be referred to our Lung Nodule Clinic. Patients will meet with physician assistants, pulmonologists, and sometimes, thoracic surgeons, who have extensive knowledge of lung nodule management. Our services include initial consultations, reviews of CT images, risk calculation and volumetric analysis of pulmonary nodules, surgical and non-surgical biopsies and advanced bronchoscopy with guided technology.

Lung Cancer Screening

Cleveland Clinic is now screening for lung nodules. The screening can help the physician and patient look for signs of lung cancer before the disease has caused someone to have symptoms. The goal of screening is to detect the disease early in its course, when it is easier to treat. Learn more about lung cancer screening.

View Our Treatment Outcomes

Our Outcomes offer detailed information and data to help patients and their physicians make informed decisions about treatment for a wide-range of respiratory issues.

Make an Appointment

To make an appointment with one of our specialists, please call 216.444.6503 or toll-free at 800.223.2273, ext. 46503.

Health Information

Health Information

Lung Cancer Treatment Guide

Download our free Lung Cancer Treatment Guide to learn more about lung cancer and the possible medical and surgical treatment options including:

  • What you need to know about lung cancer
  • How lung cancer is diagnosed and managed
  • Stages of lung cancer
  • Types of lung cancer
  • Treatment options
  • Clinical trials
  • Patient services

Download Our Lung Cancer Treatment Guide

Lung Cancer Screening

Lung Nodules

Our Doctors

Our Doctors

Research & Clinical Trials

Research & Clinical Trials

At Cleveland Clinic, we are constantly striving to find new ways of helping patients with lung cancer through research and clinical trials.

Oncocyte A study to Evaluate a Panel of Blood Biomarkers for Use in Patients Undergoing Evaluation for Lung Cancer, ONC-LN-04

This study sponsored by Onocytes primary objective is to develop a blood-based gene expression signature to be used in the detection of lung cancer in patients who underwent radiologic screening for lung cancer and had lung nodules detected.

Eligibility: (1) Patients 21 years of age or older, history of smoking tobacco, either current or past (2) Detection of a lung nodule no larger than 3cm. Patients that have current or recurrent lung cancer are not eligible for this study.


STUDY COORDINATOR: Stuart Houltham | 216.445.1056

Pragmatic Trial of More Versus Less Intensive Strategies for Active Surveillance of Patients With Small Pulmonary Nodules

In conjunction with the Patient Centered Outcomes Research Institute (PCORI) and Kaiser Permanente of California, the main objective of the “Pragmatic trial of more versus less intensive strategies for active surveillance of patients with small pulmonary nodules,” also known as the “Lung Nodule Surveillance Trial (LNST),” compares two protocols for lung nodule evaluation, with cluster randomized assignment to treatment groups at the level of the hospital or health system. The design of the trial is a hospital-based cluster randomized trial of more frequent surveillance versus less frequent surveillance of pulmonary nodules, and immediate or delayed participation in quality improvement collaboratives. Existing medical information systems at each facility will be used to passively enroll patients in the trial. Patients will be enrolled at the time they undergo chest commuted tomography and are found to have a pulmonary nodule of the appropriate size range that meets our inclusion criteria, and who otherwise do not have exclusion criteria (such as no known lung cancer).


STUDY COORDINATOR: Christopher Estling | 216.445.8951

Search Lung Cancer Clinical Trials

For an accurate listing of open lung cancer clinical trials, click on the following links:

Lung Cancer Clinical Trials

For some patients, participating in a clinical trial may be the best treatment choice. Clinical trials are done to find out if new cancer treatments are safe and effective, or to see if they are better than the standard treatment. Many of today’s standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.

Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move medical knowledge forward.

There are a number of trials available for patients with lung cancer at Cleveland Clinic. These trials provide patients access to novel or experimental testing and treatment that may not be offered at other institutions. For more information about lung cancer clinical trials at Cleveland Clinic, visit the clinical trials listing.

For Medical Professionals

For Medical Professionals

Patient Referrals

Our secure online service, Dr.Connect, provides referring physicians access to patient’s treatment progress with streamlined communication from Cleveland Clinic physicians to your office, allowing continued participation in the ongoing care of patients. With the best possible treatment plans and coordinated care, our team approach benefits both the patient and the referring physician.

Lung Cancer Screening Referral Form

To refer a patient to the Lung Cancer Screening Program at Cleveland Clinic, please complete the following form. If you have any questions, please call the Lung Cancer Screening Program at 216.445.3800.
Patients must meet all the following criteria to be eligible for the screening.

  • Have a 30 pack year history of smoking (cigarettes only)
  • Ages 55-77
  • Have smoked within the past 15 years
  • Have no signs or symptoms of cancer
  • Healthy enough and willing to undergo curative intent treatment

Refer Your Patient