In collaboration with Cleveland Clinic’s Neurological Institute, pulmonologists from the Respiratory Institute operate a neuromuscular disease clinic with a singular focus on managing pulmonary complications from diaphragm paralysis, post-polio syndrome, multiple sclerosis, muscular dystrophy, myasthenia gravis, polymyositis, amyotrophic lateral sclerosis, cerebral palsy, paraplegia, inflammatory myopathies and other neuromuscular disorders.

Our team works in partnership with neurologists, sleep physicians, physical therapists, respiratory therapists, thoracic surgeons, and nutritionists to provide the most comprehensive medical care for our patients. Our team monitors patients’ symptoms and provides therapeutic interventions, when needed, including cough assistance methods, ventilatory assistance and tracheostomy.

Services and Treatments

  • Pulmonary function tests including sitting and supine spirometry, lung volumes, respiratory muscle strength, sniff nasal-inspiratory force, peak cough flows, and arterial blood gases
  • Diagnostic and therapeutic sleep studies with hypoventilation protocols.
  • In collaboration with the neurological institute: Diaphragm EMG, phrenic nerve conduction studies, diaphragm ultrasounds
  • Suction machine to clear mouth and throat secretions
  • Non-invasive ventilation
  • Home mechanical ventilation
  • Tracheostomy care
  • Cough-assist device
  • Assisted cough, breath stacking, lung recruitment
  • Vest device
  • Flu vaccine, PPSV23 and PCV-13 (pneumonia vaccines),and Tdap (Whooping cough vaccine)
  • Diaphragm plication
  • Diaphragm fluoroscopy
Health Information

Health Information

Learn more about the diseases and conditions we treat.



Research & Clinical Trials

Research & Clinical Trials

Clinical Trials

  • Noninvasive ventilation in ALS: Factors determining tolerance, impact on survival and rate of decline of lung function
  • Clinical and Physiologic Characteristics of Patients with Diaphragm Dysfunction due to Neuralgic Amyotrophy

For more information about clinical trials, please contact us directly


Below is a list of articles about neuromuscular disease and respiratory failure written by Cleveland Clinic doctors and staff.

  • Alter A. Aboussouan LS, Mireles-Cabodevila E. Neuromuscular weakness in chronic obstructive pulmonary disease: chest wall, diaphragm, and peripheral muscle contributions. Curr Opin Pulm Med 2017; 23(2):129-138.
  • Kumar A, Mireles-Cabodevila E, Mehta AC, Aboussouan LS. Sudden onset of dyspnea preceded by shoulder and arm pain. Ann Am Thorac Soc. 2016; 13(12):2261-2265.
  • Panchabhai TS, Bandyopadhyay D, Highland KB, Chaisson NF, Aboussouan LS. A 26-year-old woman with systemic lupus erythematosus presenting with orthopnea and restrictive lung impairment. Chest. 2016; 149(1):e29-33.
  • Rokadia HK, Adams JR, McCarthy K, Aboussouan LS, Mireles-Cabodevila E. Cough augmentation in a patient with neuromuscular disease. Ann Am Thorac Soc. 2015; 12(12):1888-91
  • Aboussouan LS. Sleep-disordered breathing in neuromuscular disease. Am J Respir Crit Care Med. 2015; 191(9):979-89.
  • Aboussouan LS, Mireles-Cabodevila E. Respiratory support in patients with amyotrophic lateral sclerosis. Respir Care. 2013; 58(9):1555-8.
  • Theerakittikul T, Ricaurte B, Aboussouan LS. Noninvasive positive pressure ventilation for stable outpatients: CPAP and beyond. Cleve Clin J Med. 2010; 77(10):705-14.
  • Aboussouan LS. Mechanisms of exercise limitation and pulmonary rehabilitation for patients with neuromuscular disease. Chronic Respiratory Disease 2009; 6(4):231–249
  • Aboussouan LS, Ricaurte B, Noninvasive Positive Pressure Ventilation in Acute Settings. Cleve Clin J Med 2010; 77(5):307-16
  • Aboussouan LS, Lewis R, Shy M. Disorders of pulmonary function, sleep, and the upper airway in Charcot-Marie-Tooth disease. Lung 2007;185:1-7
  • Aboussouan LS. Respiratory management in neurological diseases. Cleve Clin J Med 2005;72:511-520. [Invited review]
  • Aboussouan LS, Lattin CD, Anne VV. Determinants of time-to-weaning in a specialized respiratory care unit. Chest 2005;128;3117-3126.
  • Aboussouan LS, Lattin CD, Kline JL. Determinants of long-term mortality after prolonged mechanical ventilation. Lung 2008;186:299-306.
  • Aboussouan LS, Khan SU, Banerjee M, Arroliga AC, Mitsumoto H. Effect of noninvasive positive-pressure ventilation on pulmonary function, respiratory muscle strength and arterial blood gases in amyotrophic lateral sclerosis. Muscle Nerve 2001;24:403-409.
  • Aboussouan LS, Khan SU, Meeker DP, Stelmach K, Mitsumoto H. Effect of non-invasive positive pressure ventilation on survival in amyotrophic lateral sclerosis. Ann Intern Med 1997;127:450-453.
For Medical Professionals

For Medical Professionals

Patient Referrals

Our secure online service, DrConnect, provides referring physicians access to patient’s treatment progress with streamlined communication from Cleveland Clinic physicians to your office, allowing continued participation in the ongoing care of patients. With the best possible treatment plans and coordinated care, our team approach benefits both the patient and the referring physician.

Pulmonary and Critical Care Medicine Fellowships

Our pulmonary and critical care medicine fellowships provide board-certified general internists with the tools necessary to care for patients, who have complicated lung diseases and critical illnesses. During the three-year training period, which includes an 18-month core program and 18-month subspecialty track, fellows are exposed to a wide variety of medical problems in both the inpatient and outpatient settings.


Cleveland Clinic Respiratory Institute offers continuing medical education courses through the Center for Continuing Education. We are providers of AMA-approved continuing medical education (CME) units for physicians and physician assistants, and of continuing education units by the Ohio Nurses Association for nurses and by the Ohio Respiratory Care Board for respiratory therapists.