At Cleveland Clinic's Asthma Center, we offer the most advanced diagnostic testing and innovative treatments for adults and children with asthma. Within Cleveland Clinic's Respiratory Institute, the Asthma Center brings together physicians from allergy and immunology, pulmonary and critical care, and sports medicine (for asthma in elite athletes).
For those with asthma and co-existing conditions, such as chronic rhinosinusitis, nasal polyps, gastroesophageal reflux, inducible laryngeal obstruction, cataracts, glaucoma or osteoporosis, we also coordinate your care with specialists in gastroenterology, ophthalmology, otolaryngology, osteoporosis and metabolic bone disease, and speech therapy. Our integrated approach to patient care provides you with state-of-the-art diagnostic and treatment services and opportunities to try new medications and therapies through clinical trials.
View Our Treatment Outcomes
Our Outcomes offer detailed information and data to help patients and their physicians make informed decisions about treatment for a wide-range of respiratory issues.
What We Treat
We offer a full range of clinical services including:
- Comprehensive consultation services and ongoing care for refractory asthma (poorly-controlled asthma)
- Occupational and environmental asthma evaluation
- Specialized (e.g. Spriometry and Exhaled Nitric Oxide) testing to determine how well your asthma is being controlled
- Bronchoprovocation direct and indirect testing (i.e. Methacholine and mannitol)
- Highly specialized treatment for asthma, including new and innovative therapies from injections to procedures
- Treatment and direction for coexisting conditions that complicate asthma control
- Initial management plans for newly diagnosed asthma cases and continued care when needed
- Comprehensive patient education
- Collaboration with Obstetrics and Gynecology department to help address asthma in pregnancy
- Collaboration with the Multicultural Lung Health Center to help address asthma health disparities
Novel Diagnostic and Treatment Approaches
Our physicians have a particular expertise in refractory asthma, or poorly-controlled asthma. For patients with refractory asthma, the Asthma Center offers innovative diagnostic and treatment services that are at the forefront of asthma care including:
- Measurement of inflammatory biomarkers in exhaled breath for patients not responding to therapies, and requiring high doses of corticosteroids
- Bronchoscopic evaluation to identify potential chronic causes of asthma
- Allergen immunotherapy (allergy shots)
- Anti-IgE therapy
- Anti-Interleukin-5 therapies
- Bronchial thermoplasty: a technique designed to reduce the contractility of airway smooth muscle by applying radiofrequency energy to airway walls in selected individuals
- Aspirin desensitization: used to develop tolerance to aspirin and similar drugs for patients with aspirin-exacerbated respiratory disease
Asthma is one of the most common chronic diseases in the world, becoming more prevalent and more severe in recent years. Asthma causes the airways of the lungs (bronchial tubes) to narrow, the lining of the airways to become inflamed and irritated, causing spasms or swelling, and the cells that line the airways to produce more mucus. These changes make breathing difficult and cause symptoms, such as cough, shortness of breath, wheezing, chest tightness and excess mucus production.
Learn about symptoms, causes and triggers, diagnostic testing, treatments and management tips for asthma from our Health Library below:
Asthma Symptoms, Causes and Triggers
- Asthma Symptoms
- Asthma Causes and Triggers
- Smoking (vaping) and Asthma
- Exercise-induced Asthma
- Stress and Asthma
- Allergies and Asthma
- Obesity and Asthma
- Infection as an Asthma Trigger
Asthma in Special Populations
Appointments & Locations
To make an appointment, please call 216.444.6503.
Virtual Second Opinions
If you cannot travel to Cleveland Clinic, help is available. You can connect with Cleveland Clinic specialists from any location in the world via a phone, tablet, or computer, eliminating the burden of travel time and other obstacles.
If you’re facing a significant medical condition or treatment such as surgery, this program provides virtual access to a Cleveland Clinic physician who will review the diagnosis and treatment plan.
Following a comprehensive evaluation of medical records and labs, you’ll receive an educational second opinion from an expert in their medical condition covering diagnosis, treatment options or alternatives as well as recommendations regarding future therapeutic considerations. You’ll also have the unique opportunity to speak with the physician expert directly to address questions or concerns.
Find additional information on the following helpful links:
American Lung Association
- Asthma Control Test: Can help you and your healthcare provider determine if your asthma symptoms are well controlled. Sharing your or a family member's score with a healthcare provider may help them determine your treatment.
Asthma Treatment and Management
- Asthma Treatments
- Alternative Therapy for Asthma
- Bronchial Thermoplasty
- Asthma Management
- Traveling with Asthma
- Exercise and Asthma
Using an Inhaler
- How to Use a Peak Flow Meter
- How to Use a Metered Dose Inhaler
- How to Use Your Flexhaler Dry Powder Inhaler
- How to Use Your Diskus Dry Powder Inhaler
- How to Use Your Turbuhaler Dry Powder Inhaler
- Diagnosing Asthma
Research & Clinical Trials
The Asthma Center is an integral part of many research studies and trials. It is our mission to ensure that all possible means in which we can care for our patients and community are available to them. This includes the opportunity to be part of research studies for asthma.
One of the large multicenter studies from the National Institute of Health (NIH) in which we have engaged is the Severe Asthma Research Program.
A more recent, NIH study on asthma is novel and innovative because it evaluates how asthma can be quite different from person to person. This can then help us learn how various treatments can be helpful in certain groups and perhaps not as helpful in others. This study is called Precisions Interventions for Severe asthma (PrecISE): A comprehensive trial utilizing precision medicine in Moderate and Severe Asthmatics.
In addition to being part of NIH studies about asthma, we are also evaluating signals (called ‘biomarkers’) in severe asthma, tracking how our patients feel with treatment (outcomes), evaluating environmental triggers for asthma, and learning how to better diagnose asthma with the newest technology. Our studying these areas allows us to provide the very best care available.
The clinical and research groups are always engaging in new and exciting studies in addition to the ones listed here. We are looking for volunteers who become part of our team! For more information on our current research studies please call 216.445.1756 to speak with a research coordinator or our general number 216.444.0582
Recommended Research Readings
View helpful research publications on the topic of asthma below:
- Associations of Air Quality with Asthma During the Cleveland Multiple Air Pollutant Study (CMAPS) -Khatri SB, Newman C, Rose J, Ross K, Pillai M, Holstein A, Tailor S, Hammond S, Norris G. Am J Respir Crit Care Med. 2010; 181:A6827.
- Angioplasticity in Asthma - Asosingh K, Erzurum SC.Biochem Soc Trans. 2009 Aug;37(Pt 4):805-10.
- Association of Ambient Ozone Exposure with Airway Inflammation and Allergy in Adults with Asthma -Khatri SB, Holguin FC, Ryan PB, Mannino DM, Erzurum SC, and Teague WG. J of Asthma 2009; 46: 777-785.
- When Should a Methacholine Challenge Be Ordered for a Patient with Suspected Asthma? - Swartz, E, and Lang, D. Cleveland Clinic Journal of Medicine. 2008: 75(1): 37-40.
- Th1- and Th2- Dependent Endothelial Progenitor Cell Recruitment and Angiogenic Switch in Asthma - Asosingh K, Swaidani S, Aronica M, Erzurum SC. J Immunol. 2007, 178:6482-6494.
- The Pathology of Asthma, with Special Reference to Changes in the Bronchial Mucosa - Dunnill MS. J Clin Pathol. 1960 Jan;13:27- 33.
For Medical Professionals
Following a patient evaluation at the Asthma Center, our team provides a timely, specialized report that includes our evaluation, test results and a proposed plan of care. Our specialists may assume care for patients or provide a treatment plan to you and the patient to carry out proposed recommendations.
Our secure online service, Dr.Connect, provides referring physicians access to patient’s treatment progress with streamlined communication from Cleveland Clinic physicians to your office, allowing continued participation in the ongoing care of patients. With the best possible treatment plans and coordinated care, our team approach benefits both the patient and the referring physician.
To refer a patient, call the Asthma Center at 216.444.0582 or the Bronchial Thermoplasty Referral Line at 216.445.6266.
- Learn more about physician referrals to the Cleveland Clinic Respiratory Institute
Allergy and Clinical Immunology Fellowships
Cleveland Clinic Respiratory Institute offers two fellowships in allergy/immunology each year. Fellows will gain experience working in a multi-specialty group practice setting, with a busy outpatient allergy/immunology practice and have the opportunity to do elective rotations in asthma, dermatology, otolaryngology, pulmonary and critical care, radiology, rheumatology, infectious diseases, and more.
Pulmonary and Critical Care Medicine Fellowships
Our pulmonary and critical care medicine fellowships provide board-certified general internists with the tools necessary to care for patients, who have complicated lung diseases and critical illnesses. During the three-year training period, which includes an 18-month core program and 18-month subspecialty track, fellows are exposed to a wide variety of medical problems in both the inpatient and outpatient settings.
The Cleveland Clinic Respiratory Institute offers continuing medical education courses through the Center for Continuing Education. Current CME offerings include:
Disease Management Project
Cleveland Clinic publishes an online medical reference, the Disease Management Project, which provides nationally-established treatment guidelines for the most common diseases and conditions