Allergic and immunologic disorders, including asthma, have become much more common. Allergies now affect an estimated 50 million Americans.

Our Department of Allergy and Clinical Immunology is one of the largest in the United States, and is committed to excellence in patient care, research, education and advocacy. We offer comprehensive and evidence-based diagnosis and management for adults and children with conditions within the spectrum of allergic/immunology disorders, including asthma, food allergy, atopic dermatitis (eczema), year-round and seasonal allergic rhinitis (hay fever), anaphylaxis, sinusitis, angioedema (swelling), urticaria (hives), stinging insect allergy, common variable immunodeficiency, aspirin sensitivity syndromes, chronic cough and drug allergy.

Our physicians also have experience in diagnosis and treatment of rare and difficult-to-treat conditions including C1 inhibitor deficiency syndromes, severe asthma, systemic mast cell disorders (e.g. mastocytosis), resistant-to-treat urticaria and complex disorders of the immune system. We offer extensive evaluations that may include skin testing and challenge procedures to rule out or confirm a diagnosis.

For patients with allergic or immunologic disorders, we offer a broad range of treatment options including medications, biologic agents, immunoglobulin replacement, drug desensitization and allergen immunotherapy. 

Services and Treatments

  • Allergy (immediate hypersensitivity) skin testing
  • Allergen immunotherapy (allergy shots)
  • Biologic agents for asthma, chronic urticaria, atopic dermatitis 
  • Drug and food/food additive challenges 
  • Drug desensitization 
  • Intravenous immunoglobulin (IVIg) administration

Make an Appointment

Call 216.444.6503 or 800.223.2273, ext. 46503, or contact us online to make an appointment today.

What We Treat

What We Treat

Allergy and Immunology Diseases

Food and Drug Allergies

Environmental Allergies

Allergy Tests

  • Allergy Testing
  • Allergy Skin Tests
  • Drug Allergy Tests
  • Elimination Diet and Food Challenge Test
  • Food Diary
  • Sulfite Sensitivity Challenge Test

Allergy Treatments

What to Expect

What to Expect

Before Your Visit:

Make a list of concerns or questions

  • Knowing your goals or questions will help to optimize your time with us.
  • Keeping a symptom diary or list of symptoms can make it easier to remember everything at your visit.

Collect your medical records

  • Gather copies of tests or provider’s notes related to your medical concerns.
  • Fax your records to our office before your visit or bring them to your appointment. You’ll find office contact information on your Cleveland Clinic provider’s website or through your MyChart account.
  • Make a list of your medications.
  • If a provider outside of Cleveland Clinic referred you to us, please make sure you have their contact information.

Sign up for MyChart

  • With a MyChart account, you have access to all of your health information and appointments at Cleveland Clinic.
  • We use MyChart to send you pre-visit instructions or questionnaires to help you prepare for your visit. Please review these before you see us.
  • You can use MyChart to communicate with your provider after your visit.

During Your Visit:

  • One of our experts will go over your symptoms, medical history, and any prior testing and/or treatment with you.
  • Our specialists will listen to your concerns and answer your questions. Then, they’ll use their knowledge and expertise to craft a personalized treatment plan to match your needs and goals.
  • We may recommend skin testing at your visit. We’ll send you instructions through MyChart on how to prepare for testing. Please review these carefully. We can do same day testing to select foods, inhalants and penicillin. For other drug or insect allergies, you may need to return at a later date to complete testing. It’s important to know that we do not do patch testing in our clinic. You’ll need to make an appointment with our dermatology department to have this done. Please contact our office if you have any questions.
  • If you’re late to your appointment, you may need to wait until the provider can fit you into their schedule, and/or testing may need to be rescheduled.

After Your Visit:

  • If a provider referred you to our clinic, we’ll share our recommendations with them.
  • We’ll talk with you about when to follow up to review results or to see how you’re responding to treatment.
  • If you’re traveling to see us, you may consider having a local provider help you complete our recommendations and/or continue your treatment.
  • If we recommend you see another specialist, we’ll try to schedule these consultations as soon as possible.
Our Doctors

Our Doctors

Research & Clinical Trials

Research & Clinical Trials

Clinical trials (or research studies) help us create the medicine of tomorrow. They provide hope through offering testing of new drugs, new surgical techniques or other treatments before they are widely available.

We can help you access hundreds of clinical trials across all specialty areas. Our new searchable online trials tool makes identifying treatment opportunities easier than ever.

For Medical Professionals

For Medical Professionals


Allergy and Immunology Fellowships

Allergy/immunology training at the Cleveland Clinic fosters the skills to be successful in clinical practice or a career at an academic center. The fellowship includes exposure to a wide range of patients with common and uncommon conditions. Fellows work closely with faculty who are dedicated to fulfilling the educational mission of the Cleveland Clinic, through both immunology and allergy treatments and elective rotation in asthma, dermatology, otolaryngology, pulmonary and critical care, radiology, rheumatology, infectious diseases, and/or other areas. Learn more about our allergy/immunology fellowships.


Cleveland Clinic's Respiratory Institute offers continuing medical education courses through the Center for Continuing Education. We are providers of AMA-approved continuing medical education (CME) units for physicians and physician assistants, and of continuing education units by the Ohio Nurses Association for nurses and by the Ohio Respiratory Care Board for respiratory therapists.

Appointments & Locations

Appointments & Locations

To make an appointment, please call 216.444.6503.

Virtual Second Opinions

If you cannot travel to Cleveland Clinic, help is available. You can connect with Cleveland Clinic specialists from any location in the world via a phone, tablet, or computer, eliminating the burden of travel time and other obstacles.

If you’re facing a significant medical condition or treatment such as surgery, this program provides virtual access to a Cleveland Clinic physician who will review the diagnosis and treatment plan. Following a comprehensive evaluation of medical records and labs, you’ll receive an educational second opinion from an expert in their medical condition covering diagnosis, treatment options or alternatives as well as recommendations regarding future therapeutic considerations. You’ll also have the unique opportunity to speak with the physician expert directly to address questions or concerns.

Learn more about virtual second opinions