Allergic and immunologic disorders, including asthma, have become much more common. Allergies now affect an estimated 50 million Americans.

Our Department of Allergy and Clinical Immunology is one of the largest in the United States, and is committed to excellence in patient care, research, education and advocacy. We offer comprehensive and evidence-based diagnosis and management for adults and children with conditions within the spectrum of allergic/immunology disorders, including asthma, food allergy, atopic dermatitis (eczema), year-round and seasonal allergic rhinitis (hay fever), anaphylaxis, sinusitis, angioedema (swelling), urticaria (hives), stinging insect allergy, common variable immunodeficiency, aspirin sensitivity syndromes, chronic cough and drug allergy.

Our physicians also have experience in diagnosis and treatment of rare and difficult-to-treat conditions including C1 inhibitor deficiency syndromes, severe asthma, systemic mast cell disorders (e.g. mastocytosis), resistant-to-treat urticaria and complex disorders of the immune system. We offer extensive evaluations that may include skin testing and challenge procedures to rule out or confirm a diagnosis.

For patients with allergic or immunologic disorders, we offer a broad range of treatment options including medications, biologic agents, immunoglobulin replacement, drug desensitization and allergen immunotherapy. 

Services and Treatments
  • Allergy (immediate hypersensitivity) skin testing
  • Allergen immunotherapy (allergy shots)
  • Biologic agents for asthma, chronic urticaria, atopic dermatitis 
  • Drug and food/food additive challenges 
  • Drug desensitization 
  • Intravenous immunoglobulin (IVIg) administration

Make an Appointment

Call 216.444.6503 or 800.223.2273, ext. 46503, or contact us online to make an appointment today.

Our Doctors

Our Doctors

Health Information

Health Information

Allergy and Immunology Diseases

Food and Drug Allergies

Environmental Allergies

Allergy Tests

  • Allergy Testing
  • Allergy Skin Tests
  • Drug Allergy Tests
  • Elimination Diet and Food Challenge Test
  • Food Diary
  • Sulfite Sensitivity Challenge Test

Allergy Treatments

Research & Clinical Trials

Research & Clinical Trials

Systemic Allergic Reactions to SARS CoV-2 Vaccination

The SARS Vaccination study is sponsored by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. Cleveland Clinic, along with approximately 39 other centers across the United States, will be participating in this study.

The SARS Vaccination study is for people ages 18-69 years old with a history of serious allergic reactions or mast cell disorders. People who do not have a history of allergies can join the study too.

The purpose of the SARS Vaccination study is to look at two vaccines, the Pfizer-BioNTech COVID-19 Vaccine and the Moderna COVID-19 Vaccine, to see:

  1. If people with a history of allergic reactions or a mast cell disorder are more likely to have an allergic reaction to these vaccines compared to people without a history of allergic reactions
  2. If certain factors increase risk of an allergic reaction to these vaccines.

Participants will be compensated for time and travel expenses.

To learn more about this study or register, please visit: URL HERE

Principal Investigator: David Lang, MD
Study Coordinator: JoAnne Baran-Smiley, BSN, RN




For Medical Professionals

For Medical Professionals


Allergy and Immunology Fellowships

Allergy/immunology training at the Cleveland Clinic fosters the skills to be successful in clinical practice or a career at an academic center. The fellowship includes exposure to a wide range of patients with common and uncommon conditions. Fellows work closely with faculty who are dedicated to fulfilling the educational mission of the Cleveland Clinic, through both immunology and allergy treatments and elective rotation in asthma, dermatology, otolaryngology, pulmonary and critical care, radiology, rheumatology, infectious diseases, and/or other areas. Learn more about our allergy/immunology fellowships.


Cleveland Clinic's Respiratory Institute offers continuing medical education courses through the Center for Continuing Education. We are providers of AMA-approved continuing medical education (CME) units for physicians and physician assistants, and of continuing education units by the Ohio Nurses Association for nurses and by the Ohio Respiratory Care Board for respiratory therapists.

Appointments & Locations

Appointments & Locations

To make an appointment, please call 216.444.6503.

Virtual Second Opinions

If you cannot travel to Cleveland Clinic, help is available. You can connect with Cleveland Clinic specialists from any location in the world via a phone, tablet, or computer, eliminating the burden of travel time and other obstacles.

If you’re facing a significant medical condition or treatment such as surgery, this program provides virtual access to a Cleveland Clinic physician who will review the diagnosis and treatment plan. Following a comprehensive evaluation of medical records and labs, you’ll receive an educational second opinion from an expert in their medical condition covering diagnosis, treatment options or alternatives as well as recommendations regarding future therapeutic considerations. You’ll also have the unique opportunity to speak with the physician expert directly to address questions or concerns.

Learn more about virtual second opinions