The mission of the Center for Renal Diseases is to diagnose and prevent kidney disease, anticipate complications, and treat renal problems before they become life threatening. The center is staffed with experienced nephrologists and other healthcare professionals who develop and implement customized treatment for polycystic kidney disease (PKD), kidney stones, glomerulonephritis (GN), and the Anemia Clinic.
What We Treat
- Glomerulonephritis (GN)
- Alport Syndrome
- Anca Associated Vasculitis
- Focal Segmental Glomerulosclerosis
- Henoch Schonlein Purpura
- Immunoglobulin A Nephropathy
- Lupus Nephritis
- Membranous Glomerulopathy
- Membranoproliferative Glomerulonephritis
- Minimal Change Disease
- Post Infectious Glomerulonephritis
- Thin Basement Membrane
- Thrombotic Microangiopathies
- Hemolytic Uremic Syndrome
- Polycystic Kidney Disease
Glomerulonephritis is a group of diseases which result in injury to the glomerulus. The glomerulus is the part of the kidney that filters the blood, which is the first step in the process of making urine. This can result from either an attack by your own immune system (autoimmune), scarring or other damage. When the glomeruli are injured, they are not able to rid the body of waste materials and extra water. The Glomerular Diseases Clinic is staffed with experienced nephrologists and other healthcare professionals who develop and implement customized treatment for patients with this unusual condition. The team meets regularly with pathologists to review biopsies and treatment plans, discuss advances in the field and ensure optimal care for patients.
The Glomerulonephritis Board is a medical board composed of world recognized nephrologists, rheumatologists, immunologists, renal pathologists and other interested physicians whom review complex nephrological glomerulonephritis cases.
- Individual patient cases are presented to the medical board for diagnosis, and treatment recommendations are made based on the clinical history, laboratory work, and kidney biopsy.
- The most current evidence based medicine is used in recommending management and treatment strategies.
- Patients benefit by having leading specialists discuss their glomerulonephritis in a multidisciplinary discussion.
- The board discusses Glomerulonephritis conditions including, but not limited to: lupus nephritis, anti-glomerular basement membrane disease, membranous glomerulonephritis, and focal segmental glomerulosclerosis (FSGS).
- The board participates in National Institutes of Health trials and other impact trials critical to understanding and treating GN.
- Requests for a case review by the GN board can be made by local nephrologists or patients.
Polycystic Kidney Disease Clinic (PKD)
The PKD Clinic uses a comprehensive medical evaluation including genetic testing and counseling, imaging of the kidneys and associated organs, and a treatment program designed by an experienced nephrologist.
- Expanded clinical services, including diet and fluid management, monitoring by trained nurses and regular evaluations by committed nephrologists.
- Specialized services for surgical management of PKD complications.
- Access to and support from experienced pediatric nephrologists when appropriate.
- A basic research team that works in areas relevant to PKD, such as cell signaling pathways that effect cell growth, experimental work in biological models of PKD and kidney tissue studies.
- The PKD Clinic is engaged in important national PKD research studies.
- The center is actively building its PKD registry, which will serve as a valuable foundation for a comprehensive PKD Clinic.
Research & Innovation
Cleveland Clinic is a leader in research to uncover innovative ways of diagnosing and treating renal diseases through evidence-based medicine.
This is an observational trial designed to characterize the natural decline of renal function markers such as glomerular filtration rate, creatinine, proteinuria and β-2 microglobulin in Alport syndrome patients.
The Department of Nephrology is a participant in the first national randomized clinical trial of treatments for PKD. The HALT-PKD study involves individuals with autosomal dominant polycystic kidney disease (ADPKD), the most common inherited form of PKD. Participants are given drugs to control hypertension. The study will use kidney growth to measure the effectiveness of an intervention.
This study is important because hypertension complications, including stroke and heart attack, affect many more individuals with ADPKD than with ADPKD-specific conditions, such as liver cysts or brain aneurysms. The goal of this study is to discover methods to slow the progression of ADPKD and related health conditions.
In addition to the HALT-PKD Trial, a pilot study is under way at Cleveland Clinic to examine the effects of sirolimus in reducing renal cysts and kidney volume in ADPKD patients. Traditionally, sirolimus is an immunosuppressant used in combination with cyclosporine and a steroid medication to prevent the body from rejecting a kidney transplant. The Center for Renal Diseases is at the forefront of research and testing of medications that could change the way PKD is treated in the future.
MENTOR (Membranous Nephropathy Trial of Rituximab)
Patients with idiopathic membranous nephropathy are randomly assigned to a trial of cyclosporine (given as a pill) or rituximab (given intravenously). The goal is to reduce protein loss in urine without encountering the risks typically associated with steroid therapy. Participants will be compared at 24 months (12 months after stopping the medication).
NEPTUNE (The Nephrotic Syndrome Study Network)
This is an observational study of patients with nephrotic syndrome who undergo a medically indicated kidney biopsy. The primary study outcomes being followed are changes in the amount of urine protein and kidney function.