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Peripartum Cardiomyopathy

Medically Reviewed.Last updated on 09/04/2026.

Peripartum cardiomyopathy is a weakness of your heart muscle that happens in the last month of pregnancy or within five months after delivery, and doesn’t come from any other cause. This condition leads to heart failure and can be fatal. Symptoms include fatigue, heart palpitations and shortness of breath.

What Is Peripartum Cardiomyopathy?

Normal heart compared to one with peripartum cardiomyopathy
Peripartum cardiomyopathy harms the left ventricle in your heart, making it less able to pump blood to your body.

Peripartum cardiomyopathy (PPCM) is a rare condition that weakens your heart muscle during or after pregnancy. This lowers your heart’s ability to pump blood to the rest of your body (heart failure). It can be life-threatening. PPCM affects women in the last month of pregnancy or up to five months after delivery. This is why people also call it postpartum cardiomyopathy or pregnancy-associated cardiomyopathy.

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PPCM can damage one or both of your lower heart chambers. Most commonly, it affects the left ventricle, making it hard for this chamber to pump oxygen-rich blood throughout your body. Sometimes, it can weaken both the right and left ventricles.

An early diagnosis is key for getting proper treatment and greatly increases your chances of a smooth recovery.

Peripartum cardiomyopathy isn’t common. In the U.S., it affects 1 in 1,500 to 1 in 4,000 live births. It happens more often in women older than 30 and in Black women.

Symptoms and Causes

Symptoms of peripartum cardiomyopathy

Peripartum cardiomyopathy symptoms are easy to miss because many of them are like what you feel during pregnancy. Symptoms may include:

  • Shortness of breath, even at rest
  • Fatigue
  • Swelling in your lower body
  • Heart palpitations
  • Dry cough
  • Swollen neck veins
  • Lightheadedness
  • Low blood pressure or blood pressure that drops suddenly when you stand up
  • Chest pain
  • Trouble lying flat on your back

Peripartum cardiomyopathy causes

Researchers don’t know what causes peripartum cardiomyopathy. But they think possible causes include:

  • Hormonal changes during pregnancy (specifically, a hormone called prolactin)
  • Preeclampsia
  • Genetic variation for cardiomyopathy
  • Stress of pregnancy and delivery

Risk factors

Peripartum cardiomyopathy has many risk factors. The more risk factors you have, the more likely you are to develop it.

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Risk factors include:

  • High blood pressure
  • Diabetes
  • Obesity
  • Selenium and zinc deficiency
  • Substance use disorder (SUD)
  • First pregnancy
  • Pregnancy with twins or triplets
  • Prior diagnosis of PPCM
  • Use of IVF to get pregnant
  • Preeclampsia and eclampsia
  • Anemia
  • Thyroid disease
  • Asthma or autoimmune disease flare-up
  • Extended use of medicine to delay delivery if you have preterm contractions
How to lower your risk

The best way to prevent peripartum cardiomyopathy is to do what you can to keep your heart healthy. While you can’t avoid all risk factors, you can manage others by:

  • Eating nutritious foods or taking prenatal vitamins
  • Getting regular physical activity
  • Avoiding tobacco products and alcohol
  • Managing conditions like overweight or obesity
  • Checking your blood pressure regularly and treating it if needed

If you had heart failure during a previous pregnancy, talk with a healthcare provider about your risk factors if you’re planning to get pregnant again. For many women, PPCM happens more than once. If you have it with one pregnancy, you’re more likely to have it again.

Complications of this condition

As your heart gets weak and tired, it can’t pump blood as well to your organs. This affects your whole body.

Life-threatening complications may include:

  • Abnormal heart rhythms (arrhythmias)
  • Sudden cardiac arrest
  • Cardiogenic shock
  • Severe heart failure
  • Failure of other organs
  • Issues from a blood clot
  • Injury to your brain

Diagnosis and Tests

How doctors diagnose this condition

Your healthcare provider will check your left ventricular ejection fraction (LVEF). They usually check this with an echocardiogram.

LVEF refers to how well your left ventricle can pump blood out of your heart. Providers describe your LVEF as a percentage, and a higher number is better. Normally, your LVEF is 50% to 70%. Peripartum cardiomyopathy reduces your LVEF to less than 45%. The lower your LVEF, the more serious the condition.

Your provider will diagnose you with PPCM if you meet all three of these criteria:

  • Your LVEF is less than 45%.
  • You develop heart failure near the end of pregnancy or within five months of delivery.
  • Your provider can’t find any other cause for the heart failure.

In referring to the condition, your provider may call it Class I, II, III or IV. The higher the number, the more severe your case. An early diagnosis reduces your risk of dying from PPCM and allows you to get treatment as soon as possible. If you get a diagnosis after the condition gets worse, you’re more likely to have serious complications, like continued heart problems.

Your provider will do a physical exam to look for signs of extra fluid in your body. They’ll use a stethoscope to check for abnormal heart sounds. Then, you’ll have tests that may include:

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  • Blood tests: These can tell if your heart has damage and how well certain organs are working.
  • Electrocardiogram (ECG/EKG): This can detect a problem with your heart’s rhythm.
  • Chest X-ray: This can show an enlarged heart and fluid in your lungs.
  • Echocardiogram: This will show your LVEF, which is an essential part of your diagnosis.
  • Heart MRI: A provider can use this to measure your heart chambers.
  • Heart catheterization: This procedure can tell you how well your heart muscle works.
  • Myocardial biopsy: A provider can take a sample and examine it for signs of damage.

These tests will reveal any heart problems that you had before your pregnancy. Some people have heart problems for years and don’t know until they start having symptoms during pregnancy.

Management and Treatment

How is it treated?

Peripartum cardiomyopathy treatment manages heart failure symptoms and helps your heart recover. The condition doesn’t go away on its own.

If you get a diagnosis during pregnancy, your provider will make sure any medications are safe for the fetus. They’ll talk with you about treatment options and discuss possible side effects. You’ll also likely work with a team of providers who can discuss the impact of heart disease on pregnancy.

You’ll probably need medications, like:

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Rarely, you may need other treatments, like:

  • A wearable or implantable cardiac defibrillator
  • left ventricular assist device (LVAD), which is a permanent implanted mechanical heart pump
  • Heart transplant, if you don’t respond to therapy

When should I see my healthcare provider?

If you have any symptoms of peripartum cardiomyopathy, call your healthcare provider right away. You’ll have regular appointments during treatment. Once your heart is working well again, you’ll need a provider to check your heart once a year or more often. Regular checkups will help them catch the condition early if it returns.

Follow your treatment plan and call your provider to talk about any problems or changes you notice. Ask for a referral to a counselor if you feel anxious or depressed.

Call 911 or your local emergency services number, or go to the ER, if you have:

  • Chest pain
  • Heart palpitations
  • Fainting
  • Any new symptoms

Outlook / Prognosis

What can I expect if I have this condition?

If you have peripartum cardiomyopathy, you’ll work closely with your healthcare provider to monitor your health and the fetus’s health.

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Your provider will also create a delivery plan. If your heart failure is stable, your provider will likely prefer you have a vaginal delivery. But with PPCM, you’re more likely to have a cesarean delivery (C-section).

After delivery, you’ll keep working with your provider to manage your care. How you feel and how quickly you recover depend on many factors. The most important factor is your left ventricular ejection fraction (LVEF). If your LVEF is less than 30% at diagnosis, you’re at a higher risk of serious complications.

For some people, peripartum cardiomyopathy becomes permanent. For others, treatment can manage the symptoms and restore some or all heart function. This can take days, weeks, months or years. But you’ll likely need to keep taking medicine for at least a year after your heart function recovers.

You’ll have to monitor your health and work closely with your provider, even after your heart function returns to normal. That’s because you can have a heart failure relapse later. Also, you may still feel long-term effects, like reduced exercise capacity.

Life expectancy with peripartum cardiomyopathy depends on your condition, how well the treatment works and many other factors related to your overall health. Your risk of dying is higher with a lower ejection fraction (LVEF). Also, the outlook isn’t as good for those who need a medical device to help their heart function.

Researchers estimate that up to 3 in 10 people in the world with this condition don’t survive. In the U.S., up to 1 in 10 don’t survive.

A note from Cleveland Clinic

When you’re preparing to have a baby, you don’t expect to have a heart issue at the same time. It can be overwhelming to juggle both. Your team of healthcare providers will help your heart get stronger.

If you’re pregnant and have any PPCM risk factors, talk with your provider. An early diagnosis is vital for getting the treatment you need and reducing the risk of serious complications.

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Medically Reviewed.Last updated on 09/04/2026.

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References

Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards.

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