Cleveland Clinic’s Endoluminal Surgery Center is dedicated to delivering the highest quality of care for patients with precancerous and early cancerous lesions of the gastrointestinal tract. This includes early cancerous lesions of the esophagus and stomach, and duodenal and colorectal polyps.

These lesions have traditionally required surgical resection, but advances in technology and endoscopic techniques have enabled the ability to remove these lesions through an endoscope, a long, thin, flexible instrument. This allows patients to avoid surgery, keep their native organs and have an improved quality of life.

Our team is passionate and dedicated to delivering world class care to our patients, and we look forward to taking care of you.

Patient Path to Endoluminal Surgery Center | Digestive Disease & Surgery Institute | Cleveland Clinic
Treatments & Procedures

Treatments & Procedures

Cleveland Clinic has world class expertise in endoscopic techniques that give our patients the best chance to avoid invasive surgery and allows the patient to maintain their quality of life.

Meet Our Team

Meet Our Team

Make an Appointment

Make an Appointment

Call 216.444.7000 to make an appointment with any of our experts.

Our office is located at Cleveland Clinic Main Campus.

Patient Resources

Patient Resources

For More Information

Butts & Guts Podcast

Health Essentials Blog



Frequently Asked Questions about Endoscopic Submucosal Dissection (ESD) and Endoscopic Mucosal Resection (EMR)

What is the difference between ESD (Endoscopic Submucosal Dissection) and EMR (Endoscopic Mucosal Resection)

The ESD procedure removes the entire polyp in one piece, while the EMR removes the entire polyp in multiple pieces. The approach that is best for your polyp is chosen based on the type, location, shape, and/or size of the polyp.

Why couldn’t my GI doctor remove this polyp? Why do I need to see a specialist?

Polyps which are difficult to remove during a regular colonoscopy may include those which are of a larger size, those which are located in a difficult spot in the colon, and/or those which are misshapen. For these difficult types of polyps, a regular colonoscopy may not be able to completely remove the polyp. This is why you would be referred for the ESD or EMR procedure.

Why does a non-cancerous polyp have to be removed?

Removing non-cancerous colorectal polyps is necessary to interrupt their progression from non-malignant (adenoma) to malignant tumors (carcinoma). Leaving the polyp in the colon could lead to health concerns later in life, including colon cancer.

What is the benefit of having an ESD or EMR?

In the past, these large and difficult colon polyps required a colectomy, or the surgical removal of part of the colon, for treatment. Now, with the option for ESD or EMR, patients are able to keep their colon intact, while also removing the troublesome polyp. These techniques are just like a colonoscopy, which is much less invasive than colorectal surgery, and leads to decreased complications after the procedure.

Are there any restrictions after the ESD or EMR?

Since these procedures are a specialized type of colonoscopy, there are no major restrictions afterwards. This is another benefit to the ESD and EMR procedures.

What is the follow up after an ESD/EMR procedure?

Typically, you will need a colonoscopy in 6 months after the ESD/EMR procedure – unless otherwise directed by your doctor. This is to survey the area where the polyp was removed, and can typically be completed by your local gastroenterologist.

How long are the ESD and EMR procedures?

Typically these procedures lasts approximately one hour or up to one and a half hours.

Do I have to do a bowel prep for these procedures?

Yes, you will receive instructions regarding the bowel prep via mail and/or MyChart.

For Medical Professionals