Cleveland Clinic’s HIPEC program is one of only a few programs in the country to perform HIPEC, which stands for Hyperthermic (or Heated) Intraoperative Peritoneal Chemotherapy.

HIPEC is used to treat cancers that have spread to the lining of the abdominal cavity, such as those of the appendix, colon, stomach and ovaries.

Digestive Disease & Surgery Institute physicians collaborate with Cleveland Clinic Cancer Center and the Ob/Gyn & Women's Health Institute for HIPEC treatment.

Cleveland Clinic is recognized in the U.S. and throughout the world for its expertise and care.

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If you have questions or would like to schedule a consultation, please call 216.444.7000.

About the HIPEC Treatment

About the HIPEC Treatment

HIPEC is an alternative and innovative method of delivering chemotherapy, which is commonly used to treat many types of cancer, to the body. Unlike traditional chemotherapy that is delivered intravenously, HIPEC delivers chemotherapy directly into the abdomen making it a good option for cancers that originated in or have spread to the abdominal cavity.

How does HIPEC work?

First, your surgeon removes any visible tumors from the abdomen. Next, HIPEC delivers heated chemotherapy directly inside the abdomen to help destroy any remaining cancer cells and very small tumors that cannot be seen by the surgeon. This is because the chemotherapy circulates inside the abdomen, allowing it to reach more places. The goal of HIPEC is to prevent these cells from growing into new tumors and causing the cancer to return.

What are the benefits of HIPEC procedures?

  • HIPEC allows for a higher concentration of chemotherapy to be delivered into the abdomen more effectively and safer than standard chemotherapy, which is delivered intravenously.
  • This type of chemotherapy is best at killing cancer cells that are too small to be seen with the naked eye.
  • Chemotherapy delivered through HIPEC causes fewer side effects than intravenous chemotherapy. This is because the high concentrations of chemotherapy solution are unable to cross what is known as the peritoneal plasma barrier.
  • Experts say that pairing surgery and HIPEC together may be more beneficial than chemotherapy alone.

Am I a candidate for HIPEC?

Typical HIPEC patients are those with certain Stage IV abdominal cancers. Many are seeking an alternative to traditional chemotherapy or radiation therapy, as these options offer limited success treating advanced abdominal cancers. Patients also may have been told that no other treatment will work, but are still hoping to find a solution.

But HIPEC is not for everyone. At Cleveland Clinic’s Digestive Disease & Surgery Institute (DDSI), our multidisciplinary team of experts can conduct a thorough evaluation to determine if you are a candidate. In addition to having Stage IV abdominal cancers, other factors that will be considered include any other existing medical conditions, the location of the cancer, surgical history and the patient’s overall physical strength.

Our Doctors Schedule a Consultation

Schedule a Consultation

To schedule a consultation or for additional questions, please call 216.444.7000.

Patient Resources

Patient Resources

Treatment Guide

Additional information about HIPEC treatment

For Medical Professionals

For Medical Professionals


  • To refer a patient to Cleveland Clinic’s HIPEC program, please call our Referring Physician Hotline 855.REFER.123 (855.733.3712).

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