What is endoscopic submucosal dissection (ESD)?

Endoscopic submucosal dissection (ESD) is a minimally invasive procedure that removes cancer from the gastrointestinal tract of a patient without removing the organ involved. This allows the patient to maintain quality of life.

The gastrointestinal tract is the passageway through which food travels from the mouth to the anus, and includes the esophagus (the “food tube”), stomach, small bowel and colon.

What are esophageal and gastric cancers?

Esophageal and gastric cancer are conditions in which malignant (cancerous) tumors develop through a series of changes (dysplasia) in the cells of the esophagus or stomach. Treatments include ESD, surgery, brachytherapy radiation, chemotherapy, and combination therapy (radiation and chemotherapy).

Last reviewed by a Cleveland Clinic medical professional on 02/27/2019.

References

  • Bhatt A, Abe S. Indications and Techniques for Endoscopic Submucosal Dissection. Am J Gastroenterol 2015 Jun;110(6):784-91.
  • Mejía-Pérez LK, Abe S. A minimally invasive treatment for early GI cancers. Cleve Clin J Med 2017 Sep;84(9):707-717.
  • Mehta N, Strong AT. Optimal injection solution for endoscopic submucosal dissection: A randomized controlled trial of Western solutions in a porcine model. Dig Endosc. 2018 May;30(3):347-353
  • Aadam M, Abe S. Endoscopic submucosal dissection for superficial esophageal cancer. Diseases of the Esophagus, Volume 31, Issue 7, 1 July 2018, doy021, https://doi.org/10.1093/dote/doy021
  • National Cancer Institute. Esophageal Cancer Treatment (PDQ®)–Patient Version. Accessed 3/4/2019.
  • Seewald, S., Ang, T.L., Pouw, R.E. et al. Management of Early-Stage Adenocarcinoma of the Esophagus: Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection. Dig Dis Sci (2018) 63: 2146. https://doi.org/10.1007/s10620-018-5158-5

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