History, Mission and Vision


The American Center for Reproductive Medicine was founded in 1993 as the research program of the Glickman Urological & Kidney Institute. Our research fellowship, ART training and summer mentorship opportunities represent one of the largest and most comprehensive academic programs of its kind in the United States.


Our mission is to conduct cutting-edge research into the causes of human reproductive and sexual disorders, leading to the development of new treatments and cures, as well as training of physicians and scientists to advance the understanding of human reproduction, infertility and sexual function.


Our vision is to mentor and train each research fellow, trainee and summer intern using an individualized approach, to develop technical expertise and the ability to work independently.


The Cleveland Clinic Andrology Laboratory and Reproductive Tissue Bank is fully accredited by the College of American Pathologists' Reproductive Laboratory Accreditation Program.


Scholarship in Teaching Award for the Training Program in Advanced Reproductive Techniques

The Case Western Reserve School of Medicine Scholarship in Teaching Awards is an annual program designed to recognize faculty contribution to education from the preceding year and promote undergraduate, graduate, and continuing medical education teaching as a scholarly activity.


The Center conducts basic science and translational research into oxidative stress, proteomics and male infertility.

For an up to date list of our publications, visit Dr. Agarwal's profile on Scopus.

A Web of Science Citation Report of Research Publications by the American Center for Reproductive Medicine from 1993 to 2013 is available here.



Ashok Agarwal, PhD

Ashok Agarwal, PhD
Director of the Clinical Andrology Laboratory and Sperm Bank

Rakesh Sharma, PhD

Rakesh Sharma, PhD
Assistant Technical Supervisor
Andrology Center and Reproductive Tissue Bank

 Sajal Gupta, MBBS, MS, TS (ABB)

Sajal Gupta, MBBS, MS, TS (ABB)
Andrology Center and Reproductive Tissue Bank

Dr. Gupta is an Assistant Professor in the Cleveland Clinic Lerner College of Medicine and the Technical Supervisor of Andrology Laboratory and Reproductive Tissue Bank. She has done her residency in Ob-Gyn from the University of Delhi and then completed two Fellowships in Reproductive Medicine: a WHO Fellowship, followed by a Research Fellowship at the Cleveland Clinic. She received a Masters in Clinical Embryology and Andrology from the Eastern Virginia Medical School. She is a recipient of several awards during her tenure in the Andrology Lab such as the Tommaso Falcone Award for Excellence in Female Infertility Research, Scholarship in Teaching Award by Case Western Reserve Medical School and Innovator Award. Dr. Gupta has published over 90 research articles in peer-reviewed scientific journals, and authored a dozen book chapters. As the Technical Supervisor of the Andrology Lab since last 13 years, Sajal is responsible for the day to day operation of Andrology Laboratories in two Cleveland location. She manages the work-flow, address any patient related problems, triages with referring physician, updates Andrology SOP and conducts competency assessment. She is responsible for the Andrology Lab Quality management, safety compliance and annual re-accreditation of Andrology laboratory through various agencies such as CAP, ODH, FDA and JCAHO. Alongside her supervisory duties, Sajal loves to work on the bench and takes care of patients coming for a variety of tests and services. She is a compassionate and dedicated professional who has trained scores of individuals in Andrology tests.

Invited Trainers, Clinical Embryologists

Christina Anagnostopoulou, MS  | Cleveland Clinic 

Christina Anagnostopoulou, MS

Christina Anagnostopoulou has studied Biology at the National University of Athens and was trained as a clinical embryologist in Aberdeen Maternity Hospital and Cleveland Clinic. She has been working in the field of assisted reproduction since 2004 and currently she is employed as a senior clinical embryologist at the ART unit AKESO-EMBRYO ART which is situated in Athens, Greece.

Since 2011 she has been providing IVF training at the American Center for Reproductive Medicine at Cleveland Clinic as visiting faculty. She is actively engaged in the theoretical part of the course by delivering lectures and in the practical part by demonstrating techniques such as oocyte denudation, ICSI, vitrification and embryo biopsy.

Israel Maldonado Ross, MS | Cleveland Clinic 

Israel Maldonado Rosas, MS

Dr. Israel Maldonado Rosas is the owner and CEO of the IVF Clinic “CITMER with branches in three Mexican cities. He was trained as a Clinical Embryologist at the Instituto Valenciano de Infertilidad at Valencia, Spain and received additional training at the Kato Ladies Clinic in Japan. In 2020, Israel was recognized as the Embryologist of the Month by the American College of Embryology (ACE). He serves as a Visiting Faculty in the ART Training Program of the American Center for Reproductive Medicine at Cleveland Clinic.



Module: 1
Course: Semenology
Duration: 40 hours (1 week)
Fees: USD 5,295

Module: 1A
Course: Routine Semen Analysis
Duration: 8 hours (1 day)
Fees: USD 950

Module: 1B
Course: Sperm Morphology
Duration: 16 hours (2 days)
Fees: USD 1,395

Module: 2A
Course: Advanced Andrology Techniques
Duration: 40 hours (5 days)
Fees: USD 5,750

Module: 2B
Course: Advanced Andrology Techniques
Duration: 80 hours (10 days)
Fees: USD 10,500

Module: 3
Course: ART Sperm Preparation
Duration: 16 hours (2 days)
Fees: USD 2,250

Module: 4
Course: Cryopreservation Techniques
Duration: 8 hours (1 day)
Fees: USD 1,950

Module: 5A
Course: IVF / ICSI / Micromanipulation
Duration: 80 hours (2 weeks)
Fees: USD 7,950

Module: 5B
Course: ICSI / Micromanipulation
Duration: 40 hours (1 week)
Fees: USD 6,200

Module: 5C Course: Advanced ART Techniques
Duration: 40 hours (1 week)
Fees: USD 6,850

Module: 5D
Course: Customized ART Training
Duration: Selected by Trainee
Fees: To Be Determined

Module: 6
Course: Vitrification
Duration: 8 hours (1 day)
Fees: USD 2,500

Module: 7
Course: Management of IVF and Andrology Labs
Duration: 16 hours (2 days)
Fees: USD 2,800

Module: 8
Course: Preparing for CAP Accreditation and FDA Inspection
Duration: 16 hours (2 days)
Fees: USD 2,800

Module: 9
Course: Training in Scientific Writing
Duration: 120 hours (15 days)
Fees: USD 10,500

Module: 10
Course: Training in Bench Research
Duration: 160 hours (20 days)
Fees: USD 15,000


  • Acquire a basic understanding of assisted reproductive techniques
  • Acquire the skills in the use of a micromanipulator
  • Impact hands-on training in intracytoplasmic sperm injection
  • Acquire skills in various assisted reproductive procedures
  • Observe aspiration and retrieval of oocytes
  • Participate actively in interactive sessions/lectures

General Teaching and Learning Methods:

  1. Fully hands-on, one-to-one laboratory training sessions will be provided under the direct tutelage of 2 highly-competent and practicing Clinical Embryologists
    * Module 5 involves training using animal models (frozen hamster oocyte and mouse embryos)
  2. Other Trainers include Andrologists, Reproductive Endocrinologists and other invited ART experts
  3. Each training session is customized to the Trainee's
    1. Professional background
    2. Level of skill and competence
    3. Specific training needs
    4. Desired outcomes obtained from attending the ART training course
  4. Interactive discussion and teaching sessions
  5. Live lectures and multimedia presentations in small group sessions

Four state-of-the-art micromanipulators dedicated solely for training purposes (IVF/ICSI)

Assessment Methods:

Aspects of the Training that will be assessed include:

  1. Knowledge: There will be a summative test comprising multiple choice questions on the practical and theoretical aspects of the ART for each module
  2. Practical Skills: Each Trainee will be individually tested for competency on specific laboratory techniques learnt during the module
  3. Presentation and Communication Skills: Each Trainee will be required to give a talk (oral with and without the aid of slides) during the course of the module

What Each Trainee Will Receive:

  1. Course Syllabus with Reading Material and Lab Protocols
  2. Free Access to the Cleveland Clinic Alumni Library
  3. Free Text Book on “Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices” edited by Dr. Peter Nagy et al, Springer. Available to candidates who register for either Module 5A, 5B, 5C or 5D
  4. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 5th Edition (digital file)
  5. Certificate of Training (issued upon successful assessment by the instructor)
  6. Daily Meal Tickets
How to Apply

How to Apply

Application Deadline

* July 30th (for training: September 3 - September 30, 2022)

* Notes:

  • Deadline is only for Modules 5A, B, C, D and 6
  • Candidates can apply throughout the year for:
    Modules 1, 1A, 1B, 2, 3, 4, 7, 8, 9 & 10
  • Candidates can choose additional modules during training from the beginning of September to the end of October

Who Can Apply

Clinicians, biologists and scientists with a background and interest in the field of Embryology, Reproductive Medicine, and Andrology are eligible.

How to Apply

When ready to apply, complete the Assisted Reproduction Training (ART) online application form.

Please upload the following documents:

  1. Recent curriculum vitae/resume

  2. A letter of recommendation from advisors, teachers, or persons who have first-hand knowledge of you.

    The writer should be able to provide an accurate assessment of the applicant’s suitability for the program rather than advocate for the applicant. The writer should briefly explain his/her relationship with the applicant (how long have you known the applicant? In what capacity have you interacted? Is the letter based on direct or indirect observations?). The writer should focus on behaviors that he/she has directly observed when describing applicants’ suitability for the program. If the writer makes comparisons of the candidate with others, be sure to include the comparison group, and the rationale behind the comparison. It is important for writers to discuss the candidate’s (1) thinking and reasoning competencies, which include the ability to think critically (using logic), quantitative reasoning, scientific inquiry, and written communication; (2) science competencies, which include living systems (applying knowledge and skill in natural sciences) and human behavior (applying knowledge of the self, others, and social systems to solve problems); (3) interpersonal competencies which include social skills (awareness of others’ needs, goals, feelings, respect), cultural competence (demonstrates knowledge and respect of social and cultural factors), teamwork (can work collaboratively with others to achieve shared goals), and oral communication (can communicate effectively with others and listens effectively; recognizes potential communication barriers and can adjust approach as needed); and (4) interpersonal competencies, which include ethical responsibility to self and others (behaves in an honest and ethical manner), reliability and dependability, resilience and adaptability, and capacity for improvement.

    Please note the above are purely suggestions for a letter writer but do not need to be strictly adhered to. Each LOR must be e-mailed or printed on an official letterhead and bear an official signature. The following is not acceptable: LORs sent as an e-mail and not printed on official letterhead, letters not bearing a signature, letters written more than 6-8 weeks before the date of submission.

  3. Passport size picture

  4. Copy of passport

    Please submit the training fees separately as directed:

  5. Visa/Green card/US citizen Status:

    Fee Information

    A non-refundable fee will be required from candidates accepted for training.

    1. See the ART Training section of the main ACRM website for the current module training fee structure: http://www.clevelandclinic.org/ReproductiveResearchCenter/questionnaire.html
    2. The fee must be submitted as a money order or certified bank check (no personal checks) made payable to "Andrology Center Research Program." This course fee should be mailed by courier (UPS or FedEx) upon acceptance to the program.
    3. Candidates can submit the training fee by electronic wire transfer from their bank. Please contact the Program Director for details of our bank account. Candidates choosing bank transfer for payment of their training fee will be charged $50 by our Center to cover the money deducted by the banks during the transfer of funds.
    4. A fee of USD $500.00 in the form of a US money order or cash is required at Orientation for instrument use. The fee helps to cover the maintenance of various instruments used in ART training as well as any kind of damage to ACRM property by a trainee.
    5. Overseas Candidates Only: A non-refundable document fee of USD $500 is required in the form of a money order or certified bank check - payable to "Cleveland Clinic Foundation." This fee is required for candidates applying from outside the United States. The fee is charged by Cleveland Clinic's Center for International Medical Education for their appointment of foreign-based candidates.
    6. Please note that there is no discount for multiple training modules (e.g. Modules 1, 2, 3 = $11,150.00; this will last 2 weeks).
    7. Request for refunds of 50% of course fees may be allowed if requests are received in writing up to 4 weeks prior to the scheduled training. No refunds will be issued if made after that time.

    Please Note: Except for Modules 5 and 6, candidates can schedule their training in all remaining modules year round.

Who to Contact

Dr. Ashok Agarwal
Program Director
Assisted Reproduction Training (ART)

American Center for Reproductive Medicine
Cleveland Clinic
10681 Carnegie Avenue, X11
Cleveland, OH 44195, USA

Tel: 216.444.9485
Fax: 216.445.6049
E-mail: [email protected]