Cognitive Disorders

Cognitive Function

Change in Cognitive Functioning in Patients With Cognitive Disorders (N = 609)

2019 Center for Brain Health, MoCA

AD = Alzheimer disease, FTD = frontotemporal dementia, LBD = Lewy body dementia, MCI = mild cognitive impairment

ᵃSome patients were categorized under more than one diagnosis (eg, MCI and FTD), resulting in higher numbers for diagnostic groups than total patients.

All patients undergo brief cognitive screening using MoCA. Typically, patients are given the MoCA during their initial visit and at various intervals afterward, and changes in MoCA score can be used to track progression of disease.¹

A MoCA score of ≥ 26 is considered normal. A total of 609 patients had at least 2 visits between 2018–2019 and 1 visit in 2019 with MoCA data available for analysis. Baseline and follow-up scores were 18.86 and 17.95, respectively, for an average change of −0.91 points. Standardizing this difference to account for varied follow-up times results in a mean annualized change of −2.64 points, with AD showing the largest annual change (−5.85) and FTD showing the smallest annual change (−0.38).

Change in MoCA Scores by Disease Group (N = 536)

2019

AD = Alzheimer disease, FTD = frontotemporal dementia, LBD = Lewy body dementia, MCI = mild cognitive impairment, MoCA = Montreal Cognitive Assessment

ᵃSome patients were categorized under more than one diagnosis (eg, MCI and FTD), resulting in higher numbers for diagnostic groups than total patients.

Cognitive functioning as measured by the MoCA remained stable or worsened for most patients with a baseline score of ≤ 25. Clinically meaningful change was defined as a change of ≥ 3 points.

References
  1. Costa AS, Reich A, Fimm B, Ketteler ST, Schulz JB, Reetz K. Evidence of the sensitivity of the MoCA alternate forms in monitoring cognitive change in early Alzheimer’s disease. Dement Geriatr Cogn Disord. 2014;37(1-2):95-103.