Cognitive Disorders

Cognitive Function

2018, Center for Brain Health, MoCA

2017-2018

AD = Alzheimer disease, FTD = frontotemporal dementia, LBD = Lewy body dementia, MCI = mild cognitive impairment

All patients undergo brief cognitive screening using MoCA. Typically, patients are given the MoCA during their initial visit and at various intervals afterward, and changes in MoCA score can be used to track progression of disease¹.

A MoCA score of ≥ 26 is considered normal.A total of 854 patients had at least 2 visits between 2017–2018 and 1 visit in 2018 with MoCA data available for analysis. Baseline and follow-up scores were 20.25 and 19.03, respectively, for an average change of -1.22 points. Standardizing this difference to account for varied follow-up times results in a mean annualized change of -1.21 points, with FTD showing the largest annual change (-4.39) and LBD showing the smallest annual change (-0.35).

Change in MoCA Scores by Disease Group (N = 710)

2018

AD = Alzheimer disease, FTD = frontotemporal dementia, LBD = Lewy body dementia, MCI = mild cognitive impairment, MoCA = Montreal Cognitive Assessment

Cognitive functioning as measured by the MoCA remained stable or worsened for most patients with a baseline score ≤25 . Clinically meaningful change was defined as a change of ≥ 3 points.

References
  1. Costa AS, Reich A, Fimm B, Ketteler ST, Schulz JB, Reetz K. Evidence of the sensitivity of the MoCA alternate forms in monitoring cognitive change in early Alzheimer’s disease. Dement Geriatr Cogn Disord. 2014;37(1-2):95-103.