Headache

Episodic Migraine

Outcomes of Treatment in Episodic Migraine Patients (N = 885)

2023

GAD-7 = Generalized Anxiety Disorder Questionnaire, HIT-6 = Headache Impact Test, PHQ-9 = Patient Health Questionnaire, PROMIS = Patient Reported Outcome Measurement Information System

In 2023, 885 patients with episodic migraine completed at least 1 questionnaire following treatment. Of the 261 patients who reported HIT-6 scores > 50 at initial evaluation, 28.7% reported improvement.¹ Of the 557 patients who reported initial PROMIS Global Health more than one-half standard deviation below the normative mean,² 84% improved or remained stable. Of the 484 patients who completed the PHQ-9 at six months follow-up and reported initial depressive symptoms above the cutoff of ≥ 10 points,³ 17.1% reported improvement of depressive symptoms on follow-up. Of the 287 patients who reported initial anxiety symptoms above the cutoff of ≥ 10 points,⁴ 20.6% reported improvement at follow-up.

References
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  2. Hays RD, Bjorner JB, Revicki DA, Spritzer KL, Cella D. Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual Life Res. 2009 Sep;18(7):873-880.
  3. Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care. 2004 Dec;42(12):1194-1201.
  4. Toussaint A, Hüsing P, Gumz A, Wingenfeld K, Harter M, Löwe B. Sensitivity to change and minimal clinically important difference of the 7-item Generalized Anxiety Disorder Questionnaire (GAD-7). J Affect Disord. 2020 Mar 15;265:395-401.