Episodic Migraine

Outcomes of Treatment in Episodic Migraine Patients (N = 2826)


HIT-6 = Headache Impact Test, PHQ-9 = Patient Health Questionnaire, PROMIS = Patient Reported Outcome Measurement Information System

In 2021, 2826 patients with episodic migraine completed at least 1 questionnaire following treatment. The median interval between initial appointment and follow-up was 265 days (range, 7-713). Of the 1927 patients who reported HIT-6 scores > 50 at initial evaluation, 69% reported stable or improved scores at their second visit.¹ Of the 1104 patients who reported initial PROMIS Global Health ˃ one-half SD below the normative mean,² 38% reported improvement. Of the 822 patients who completed the PHQ-9 at 2 visits and reported initial depressive symptoms above the cutoff of ≥ 10 points,³ 36% reported improvement of depressive symptoms on follow-up.

  1. Coeytaux RR, Kaufman JS, Chao R, Mann JD, Devellis RF. Four methods of estimating the minimal important difference score were compared to establish a clinically significant change in Headache Impact Test. J Clin Epidemiol. 2006 Apr;59(4):374-380.
  2. Hays RD, Bjorner JB, Revicki DA, Spritzer KL, Cella D. Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual Life Res. 2009 Sep;18(7):873-880.
  3. Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care. 2004 Dec;42(12):1194-1201.