Headache

Chronic Migraine

Chronic migraine refers to migraine headaches occurring at least 15 days per month, frequently associated with significant functional impairment and depression.

Outcomes of Treatment in Chronic Migraine Patients (N = 1877)

2020

HIT-6 = Headache Impact Test, PHQ-9 = Patient Health Questionnaire, PROMIS = Patient Reported Outcome Measurement Information System

In 2020, 1877 patients with chronic migraine completed at least 1 questionnaire following treatment, with a median interval between initial appointment and follow-up of 189 days (range, 7-669). Of the 1520 patients who reported HIT-6 scores > 50 at initial evaluation (higher scores indicate greater impairment secondary to headache pain¹), 24% reported improvement. Of the 932 patients who reported initial PROMIS² pain at or above the median score of 6, 90% improved or remained stable. Of the 773 patients who reported initial depressive symptoms ≥ 10 points for the PHQ-9 (higher scores indicate greater depression³), 30% reported improvement at follow-up.

References
  1. Coeytaux RR, Kaufman JS, Chao R, Mann JD, Devellis RF. Four methods of estimating the minimal important difference score were compared to establish a clinically significant change in Headache Impact Test. J Clin Epidemiol. 2006 Apr;59(4):374-380.
  2. Hays RD, Bjorner JB, Revicki DA, Spritzer KL, Cella D. Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual Life Res. 2009 Sep;18(7):873-880.
  3. Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care. 2004 Dec;42(12):1194-1201.