Thyroid Disease

What is thyroid disease?

Thyroid disease is a general term for a medical condition that keeps your thyroid from making the right amount of hormones. It can affect people of all ages.

Your thyroid is a small, butterfly-shaped gland located at the front of your neck under your skin. It’s a part of your endocrine system and controls many of your body’s important functions by producing and releasing thyroid hormones, like thyroxine (T4) and triiodothyronine (T3).

Your thyroid’s main job is to control the speed of your metabolism (metabolic rate). This is the process of how your body transforms the food you consume into energy. All the cells in your body need energy to function. When your thyroid isn’t working properly, it can impact your entire body.

Types of thyroid disease

The two main types of thyroid disease are hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid). But they each have several conditions that can cause them.

Conditions that can cause hypothyroidism include:

• Hashimoto’s disease: This is a lifelong (chronic) autoimmune condition that can cause an underactive thyroid. It’s the most common cause of hypothyroidism in countries with widely available iodized salt and other iodine-enriched foods.
• Iodine deficiency: Your thyroid needs iodine to make thyroid hormone, so a lack of the mineral in your diet can lead to hypothyroidism. It’s the most common cause of hypothyroidism in countries that don’t have iodized salt widely available. It often causes goiter (enlarged thyroid).
• Congenital hypothyroidism: Sometimes, babies are born with a missing or underactive thyroid. “Congenital” means “present from birth.” About 1 in every 2,000 to 4,000 babies have congenital hypothyroidism.

Conditions that can cause hyperthyroidism include:

• Graves’ disease: This is a chronic autoimmune condition that causes an overactive thyroid. It’s the most common cause of hyperthyroidism.
• Thyroid nodules: These are abnormal lumps on your thyroid gland. If the nodules are hyperfunctioning, they can lead to hyperthyroidism.
• Excessive iodine: When you have too much iodine in your body, your thyroid makes more thyroid hormones than you need. You may develop excessive iodine by taking certain medications, like amiodarone (a heart medication).

Conditions that can cause both hypothyroidism and hyperthyroidism at different times include:

• Thyroiditis: This is inflammation (swelling) of your thyroid gland. It typically causes temporary hyperthyroidism at first and then temporary or chronic hypothyroidism.
• Postpartum thyroiditis: This is a relatively rare condition that affects some birthing parents after pregnancy. An estimated 5% of people may experience this in the year after giving birth. It typically causes hyperthyroidism first, followed by hypothyroidism. It’s usually temporary.

How common is thyroid disease?

Thyroid disease is very common. About 20 million people in the United States have some type of thyroid condition.

What are the symptoms of thyroid disease?

There are a variety of symptoms you could experience if you have thyroid disease. Unfortunately, symptoms of a thyroid condition are often very similar to the signs of other medical conditions and stages of life. This can make it difficult to know if your symptoms are related to a thyroid issue or something else entirely.

For the most part, the symptoms of thyroid disease can be divided into two groups — those related to having too much thyroid hormone (hyperthyroidism) and those related to having too little thyroid hormone (hypothyroidism). The symptoms are often “opposites” between the two conditions. This is because hyperthyroidism speeds up your metabolism, and hypothyroidism slows down your metabolism.

Symptoms of hypothyroidism include:

• Slower-than-usual heart rate.
• Feeling tired (fatigue).
• Unexplained weight gain.
• Feeling sensitive to cold.
• Dry skin and dry and coarse hair.
• Depressed mood.
• Heavy menstrual periods (menorrhagia).

Symptoms of hyperthyroidism include:

• Faster-than-usual heart rate (tachycardia).
• Difficulty sleeping.
• Unexplained weight loss.
• Feeling sensitive to heat.
• Clammy or sweaty skin.
• Feeling anxious, irritable or nervous.
• Irregular menstrual cycles or a lack of periods (amenorrhea).

Both conditions can cause an enlarged thyroid (goiter), but it’s more common in hyperthyroidism.

What are the risk factors for thyroid disease?

You may be at a higher risk of developing a thyroid condition if you:

• Are assigned female at birth (AFAB). People AFAB are five to eight times more likely to have a thyroid condition than people assigned male at birth (AMAB).
• Have a family history of thyroid disease.
• Have Turner syndrome.
• Take a medication that’s high in iodine.
• Live in a country or area that doesn’t have iodized table salt, which can lead to iodine deficiency.
• Are older than 60, especially if you’re AFAB.
• Have received radiation therapy to your head and/or neck.

Having an autoimmune disease also increases your risk, especially if you have:

• Pernicious anemia.
• Type 1 diabetes.
• Celiac disease.
• Addison’s disease (primary adrenal insufficiency).
• Lupus.
• Rheumatoid arthritis.
• Sjögren’s syndrome.

How is thyroid disease diagnosed?

Your healthcare provider will start by asking about your symptoms and medical history and doing a physical exam. During the exam, they’ll gently feel your thyroid gland to check if it’s enlarged or if there are noticeable nodules.

Your provider will need to use some thyroid tests to confirm a diagnosis. These include:

• Blood tests: These tests can tell you if you have hypothyroidism or hyperthyroidism. There are several types of thyroid blood tests, including thyroid-stimulating hormone (TSH), T3 and T4, and thyroid antibodies.
• Imaging tests: Imaging tests, like a thyroid ultrasound, help your provider look for nodules (lumps) and/or goiter. Nuclear medicine imaging like a thyroid uptake and scan can help show if nodules are overactive.

How is thyroid disease treated?

Treatment for thyroid disease depends on the type of condition and the cause. The goal is to return your thyroid hormone levels to a healthy range.

If you have hyperthyroidism, treatment options include:

• Antithyroid drugs (methimazole and propylthiouracil): These medications stop your thyroid from making hormones.
• Radioiodine (radioactive iodine) therapy: This treatment damages the cells of your thyroid, preventing it from making high levels of thyroid hormone.
• Beta-blockers: These medications don’t affect your thyroid, but they help manage some symptoms, like rapid heart rate.
• Surgery: For a more permanent form of treatment, your healthcare provider may recommend surgically removing your thyroid (thyroidectomy). This will stop it from creating hormones. However, you’ll need to take synthetic (manufactured) thyroid replacement hormones (pills) for the rest of your life.

If you have hypothyroidism, the main treatment option is thyroid replacement medication. It’s a synthetic way to add thyroid hormones back into your body. One medication that providers commonly prescribe is levothyroxine.

Can I prevent thyroid disease?

Thyroid diseases generally aren’t preventable. This is because most cases of thyroid disease are linked to genetics and/or caused by autoimmune conditions, which you can’t prevent.

The two conditions you may be able to prevent are thyroid problems related to iodine excess or deficiency. Talk to your healthcare provider if you’re concerned about consuming a healthy amount of iodine.

Is thyroid disease a serious illness?

Thyroid diseases affect many parts of your body and health. If you consistently follow your treatment plan to manage the condition, it’s usually not serious.

But if thyroid disease is undiagnosed or not treated properly, it can cause complications.

Complications from untreated or undertreated hyperthyroidism include:

• Atrial fibrillation.
• Stroke.
• Congestive heart failure.
• Osteoporosis.

Complications from untreated or undertreated hypothyroidism include:

• Mood disorders, like depression.
• Peripheral neuropathy.
• Increased risk of heart disease and heart failure.
• Infertility.
• Myxedema coma, a sudden, life-threatening complication of severe hypothyroidism.

Can I live a normal life with thyroid disease?

A thyroid disease is often a lifelong medical condition that you’ll need to manage consistently. This often involves daily medication. Your healthcare provider will monitor your treatments and adjust them over time.

It may take some time to find the right treatment plan for you to manage your hormone levels. But you can usually live a normal life with thyroid disease.

When should I see a healthcare provider about thyroid disease?

If you have symptoms of hypothyroidism or hyperthyroidism or notice a change in your neck’s appearance where your thyroid is, see a healthcare provider. It’s important to get a diagnosis and start treatment.

If you learn that a biological family member has a thyroid disease, be sure to update your provider so they can add it to your medical record. Thyroid diseases often run in families. It’s good to know your history in case you ever develop symptoms of thyroid disease.

A note from Cleveland Clinic

Thyroid diseases are common conditions. The good news is that medication and other treatments can help manage them well. If you have symptoms of hypothyroidism or hyperthyroidism or have known risk factors for thyroid disease, talk to your healthcare provider. They’re available to help you.