Ampullary cancer is a rare type of carcinoma that forms in an area of your body called the ampulla of Vater. The ampulla of Vater is a small opening located where your bile duct and pancreatic duct join. Treatments include surgery, chemotherapy and radiation therapy.
Ampullary cancer forms in the ampulla of Vater, an opening that enters the duodenum (the first portion of your small intestine). The ampulla of Vater is located near other organs in your digestive system, including your liver and pancreas.
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This type of cancer is fairly rare. Ampullary cancer accounts for less than 1% of all cancers affecting the gastrointestinal tract.
Ampullary cancer is most common in people over the age of 70. Males are more likely than females to develop the condition. Statistically, 0.74 out of every 100,000 males will develop ampullary cancer while 0.48 out of every 100,000 females will be diagnosed with the condition.
Ampullary cancers grow fast and are more likely to spread. Generally, the more advanced the tumor, the faster it will grow.
No. However, ampullary cancer develops near the pancreatic duct and is treated in much the same way as pancreatic cancer.
Ampullary cancers form in the ampulla of Vater, while periampullary cancers originate in the bile duct, pancreas or small intestine (which is located close to the ampulla of Vater).
People with ampullary cancer usually develop jaundice (yellowing of the eyes and skin). This is because the tumor can block the bile duct. As a result, bile is unable to move into the intestines and goes into the blood instead. Other ampullary cancer symptoms include:
Experts aren’t sure what causes ampullary cancer. However, we know that cancer begins when cells develop mutations (changes) in their DNA. These abnormal cells start to multiply and grow out of control.
There are certain factors that can increase your risk of developing ampullary cancer. These risk factors include:
When ampullary cancer metastasizes, it usually spreads to the liver, lymph nodes, lungs, peritoneum (abdominal lining) and other organs. To better understand the process of metastasis, the stages of ampullary cancer are listed below:
Because the first sign of ampullary cancer is usually jaundice, yellowing of the skin is often the reason that many healthcare providers begin testing for the disease. Tests used to diagnose ampullary cancer include:
There are a few different options for treating ampullary cancer. Treatment recommendations will depend on the location, size and stage of your cancer and your overall health and healing capacity. Ampullary cancer treatment options include:
As with any procedure, complications are possible following ampullary cancer treatments. These complications can vary from person to person depending on which treatment you receive. People who undergo surgery for ampullary cancer may experience:
People who receive chemotherapy or radiation therapy for ampullary cancer may experience a number of side effects, including fatigue, hair loss, nausea, diarrhea, constipation, infertility and flu-like symptoms.
If you’ve recently undergone treatment for ampullary cancer, be sure to attend all scheduled follow-ups. These appointments allow your healthcare provider to monitor your health and address any complications before they worsen.
Because there are no avoidable risk factors associated with ampullary cancer, there is currently no known way to prevent the condition.
The only potential cure for ampullary cancer is complete removal of the tumor. This treatment is most likely to be successful when the cancer is still in the earliest stage. However, if complete removal of the tumor isn’t possible, your healthcare team will help you find ways to manage your condition.
Ampullary cancer is considered a life-limiting disease and survival rates decrease as the stage of disease increases. However, the five-year survival rate for people who undergo the Whipple procedure ranges from 20% to 61%. This means that up to 61 out of 100 people who had the Whipple procedure for ampullary cancer are still alive after five years. It’s important to note that survival rates are only estimates. They can’t tell you how you’ll respond to treatment or how long you’ll live. To learn more about survival rates for ampullary cancer, talk to your healthcare provider.
Yes, it’s possible. Following surgical resection, there is still a 33% to 60% chance for recurrence.
If you’ve been diagnosed with ampullary cancer, call your healthcare provider anytime you notice new symptoms or when you develop fever or other signs of infection.
Learning all you can about your diagnosis is essential for making well-informed decisions about your health. Here are some questions to consider asking your healthcare provider:
A note from Cleveland Clinic
An ampullary cancer diagnosis can be overwhelming. You may feel sadness, frustration, worry or anger. Consider joining a support group, which will put you in contact with others who are going through the same things. Be frank and honest with your healthcare provider, and talk with them about any emotions you’re experiencing. They can find ways to help as you navigate this difficult time. Finding the right resources can give you the information you need to make the best decisions for your health.
Last reviewed by a Cleveland Clinic medical professional on 10/04/2021.
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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy