Psychiatric Disease

Outpatient Treatment for Mood and Anxiety Disorders

Of 1572 adult outpatients with at least moderate depression, defined as a baseline Patient Health Questionnaire (PHQ-9) score greater > 10, 50.3% (N = 791) demonstrated a clinically meaningful improvement. Clinically meaningful improvement was defined as a 5-point reduction in total PHQ-9 score from baseline to follow-up.¹ Outpatients were treated with psychotherapy and/or medication management. N = patients seen for initial assessment of a mood and/or anxiety disorder(s) in 2018 for whom initial and follow-up data were available. Median duration between initial and follow-up assessment was 136 days (range, 1–363).

The Patient-Reported Outcomes Measurement Information System (PROMIS®) Global Health is a publicly available assessment tool consisting of 10 items used to measure overall physical and mental health. Scores are standardized to the general population, with a mean T-score = 50 and standard deviation = 10; higher scores indicate better function. Clinically meaningful change was defined as a 5-point change in T-score, based on one-half the standard deviation.¹

Among 1389 patients whose baseline PROMIS Mental Health score ≤ 45, 27.1% (N = 377) showed improvement, 61.5% (N = 854) remained stable, and 11.4% (N = 158) worsened. Median duration of follow-up was 189 days (range, 1–357).

Among 1196 patients whose baseline PROMIS Physical Health score ≤ 45, 29.8% (N = 357) showed improvement, 57.8% (N = 691) remained stable, and 12.4% (N = 148) worsened. Median duration of follow-up was 191 days (range, 1–359).

Outpatient Treatment for Mood and Anxiety Disorders

2018 Adult Psychiatry, All Patients

Improvement in Depressive Symptoms and Global Health-Related Quality of Life Among Adult Outpatients

PHQ-9 = Patient Health Questionnaire, PROMIS = Patient-Reported Outcomes Measurement Information System

Of 1572 adult outpatients with at least moderate depression, defined as a baseline Patient Health Questionnaire (PHQ-9) score greater > 10, 50.3% (N = 791) demonstrated a clinically meaningful improvement. Clinically meaningful improvement was defined as a 5-point reduction in total PHQ-9 score from baseline to follow-up.¹ Outpatients were treated with psychotherapy and/or medication management. N = patients seen for initial assessment of a mood and/or anxiety disorder(s) in 2018 for whom initial and follow-up data were available. Median duration between initial and follow-up assessment was 136 days (range, 1–363).

The Patient-Reported Outcomes Measurement Information System (PROMIS®) Global Health is a publicly available assessment tool consisting of 10 items used to measure overall physical and mental health. Scores are standardized to the general population, with a mean T-score = 50 and standard deviation = 10; higher scores indicate better function. Clinically meaningful change was defined as a 5-point change in T-score, based on one-half the standard deviation.¹

Among 1389 patients whose baseline PROMIS Mental Health score ≤ 45, 27.1% (N = 377) showed improvement, 61.5% (N = 854) remained stable, and 11.4% (N = 158) worsened. Median duration of follow-up was 189 days (range, 1–357).

Among 1196 patients whose baseline PROMIS Physical Health score ≤ 45, 29.8% (N = 357) showed improvement, 57.8% (N = 691) remained stable, and 12.4% (N = 148) worsened. Median duration of follow-up was 191 days (range, 1–359).

References
  1. Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care. 2004;42(12):1194-1201.

  2. Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;41(5):582-592.