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Non-Insulin Injectable Medications

Exenatide (Byetta®)

  • Onset: 10 minutes
  • Peak: 2 hours
  • Duration: 10 hours
How it works:
  • Mimics incretins, the peptides that are secreted when a person eats; incretins stimulate insulin production and help the person feel full by delaying emptying of the stomach.
Side effects:
  • Nausea
  • Vomiting
Comments/special instructions:
  • Byetta® is taken twice a day, within 1 hour of the two largest meals of the day.
  • Byetta® can be used in combination with a sulfonylurea, metformin, or thiazolidinediones.
  • Byetta® facilitates weight loss.
  • The risk of hypoglycemia is greater if Byetta® is used with insulin or a sulfonylurea.

Pramlintide (Symlin®)

How it works:
  • Symlin® is a synthetic version of amylin, a peptide that is secreted along with insulin when a person eats. Amylin helps the person feel full by delaying emptying of the stomach.
Side effects:
  • Nausea
  • Vomiting
Comments/special instructions:
  • Symlin® is indicated for patients who have Type 1 diabetes and for those
    who have Type 2 diabetes and require insulin.
  • Symlin® is administered before meals, usually at the same time as insulin.
    NOTE: Symlin® and insulin must be administered as separate injections.
  • Symlin® facilitates weight loss.

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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. For additional written health information, please contact the Health Information Center at the Cleveland Clinic 216.444.3771 or toll-free 800.223.2273 extension 4-3771 or visit www.clevelandclinic.org/health.This document was last reviewed on: 10/17/2007...#13901


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