Research Focus Overview

Research Focus Overview

The Cleveland Clinic Mellen Center has a strong track record of developing and implementing technology for routine clinical care and research. The Mellen Center, in collaboration with Dr. Jay Albert’s lab, developed the Multiple Sclerosis Performance Test (MSPT). The MSPT is a tablet-based battery of patient-reported outcomes and performance tests, including walking speed, manual dexterity, processing speed, and contrast sensitivity. The MSPT interfaces with a secure, cloud-based system to allow for integration into the electronic medical record (EMR). The MSPT is administered at all routine MS follow-up clinical encounters allowing for real-time utilization. The integration of this technology facilitates more consistent data capture of neuroperformance tests and patient-reported outcomes, which has allowed for the development of a well-characterized clinical cohort for observational research. Additionally, the use of technology enabled data capture has led to efforts to develop novel biomechanical outcomes to better characterize neurological function.

Teleneurology has been utilized at the Cleveland Clinic since 2015. As an early adopter of teleneurology for MS care, the Mellen Center has been involved in research efforts to better characterize teleneurology in regards to utilization, patient experience, and adoption, as well as disparities in access to teleneurology services. Currently, the Mellen Center is leading a multicenter Phase 1/2 trial of telehealth for comprehensive MS care funded by National Institutes of Health (NIH). This is the first randomized controlled trial to evaluate the effect of teleneurology on MS outcomes, cost, and satisfaction.


Marisa McGinley, DO


1R01NR020323-01A1, Clinical and Economic Impact of Teleneurology vs Standard in Clinic Care for Multiple Sclerosis: A Randomized Trial, McGinley (PI) 9/2022-6/2027
Contracts for industry-sponsored studies from Biogen and Genentech.



Multiple Sclerosis Performance Test: validation of self-administered neuroperformance modules
Rao SM, Galioto R, Sokolowski M, McGinley M, Freiburger J, Weber M, Dey T, Mourany L, Schindler D, Reece C, Miller DM, Bethoux F, Bermel RA, Williams JR, Levitt N, Phillips GA, Rhodes JK, Alberts J, Rudick RA.. Eur J Neurol. 2020 May;27(5):878-886. Epub 2020 Mar 2. PMID: 32009276.

Technology-enabled assessments to enhance multiple sclerosis clinical care and research.
Macaron G, Moss BP, Li H, Baldassari LE, Rao SM, Schindler D, Alberts JL, Weber M, Ayers M, Bethoux F, Boissy A, Chizmadia D, Conway DS, Fink C, Fox RJ, Gales S, Green B, Hara-Cleaver C, Jordan N, Mahajan KR, McGinley MP, Miller DM, Namey M, Rae-Grant A, Rensel M, Young H, Willis MA, Ontaneda D, Cohen JA, Bermel RA. Neurol Clin Pract. 2020 Jun;10(3):222-231. PMID: 32642324; PMCID: PMC7292568.

Technology-enabled comprehensive characterization of multiple sclerosis in clinical practice.
Baldassari LE, Nakamura K, Moss BP, Macaron G, Li H, Weber M, Jones SE, Rao SM, Miller D, Conway DS, Bermel RA, Cohen JA, Ontaneda D, McGinley MP Mult Scler Relat Disord. 2020 Feb;38:101525. Epub 2019 Nov 14. PMID: 31759186; PMCID: PMC6943942.

Expanded access to multiple sclerosis teleneurology care following the COVID-19 pandemic.
McGinley MP, Gales S, Rowles W, Wang Z, Hsu WY, Amezcua L, Bove R. Mult Scler J Exp Transl Clin. 2021 Feb 25;7(1):2055217321997467. doi: 10.1177/2055217321997467. PMID: 33738110; PMCID: PMC7934057.

Implementation and Patient Experience of Outpatient Teleneurology.
Ross L, Bena J, Bermel R, McCarter L, Ahmed Z, Goforth H, Cherian N, Kriegler J, Estemalik E, Stanton M, Rasmussen P, Fernandez HH, Najm I, McGinley M. Telemed J E Health. 2021 Mar;27(3):323-329. Epub 2020 Jun 23. PMID: 32584654; PMCID: PMC7958989.

Teleneurology as a Solution for Outpatient Care During the COVID-19 Pandemic
McGinley MP, Ontaneda D, Wang Z, Weber M, Shook S, Stanton M, Bermel R. Telemed J E Health. 2020 Dec;26(12):1537-1539. doi: 10.1089/tmj.2020.0137. Epub 2020 Jun 16. PMID: 32552509; PMCID: PMC7757521.

Providing Person-Centered Care via Telemedicine in the Era of COVID-19 in Multiple Sclerosis.
Abbatemarco JR, Hartman J, McGinley M, Bermel RA, Boissy A, Chizmadia DT, Sullivan AB, Rensel MR. J Patient Exp. 2021 Jan 12;8:2374373520981474. PMID: 34179353; PMCID: PMC8205372.

The COVID-19 Crisis: A Mental Health Perspective and Response Using Telemedicine
Sullivan AB, Kane A, Roth AJ, Davis BE, Drerup ML, Heinberg LJ. J Patient Exp. 2020 Jun;7(3):295-301. Epub 2020 May 11. PMID: 32821785; PMCID: PMC7410128.

Members & Collaborations

Members & Collaborations


External Relationships & Collaborations

  • Riley Bove, MD MSc (University of California San Francisco)
  • Josh Carlson, PhD (University of Washington)
  • Lilyana Amezcua, MD (University of Southern California)