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Department Mellen Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Consultation and Long-term Care
  • Lumbar Puncture (Spinal Tap)
View all 2 Treatment & Services +

Specialty in Diseases & Conditions

  • Acute Disseminated Encephalomyelitis (ADEM)
  • Devic's Disease (Neuromyelitis Optica)
  • Multiple Sclerosis
  • Neuroimmunology
  • Optic Neuritis
  • Pediatric Multiple Sclerosis
  • Transverse Myelitis
View all 7 Specialties +


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About Mary Rensel, MD

Mary Rensel, MD is an Assistant Professor of Medicine at the Cleveland Clinic Lerner College of Medicine and Director of Pediatric Multiple Sclerosis and Wellness at the Mellen Center of the Cleveland Clinic. She has graduated from the Medical College of Ohio and completed her Neurology and Neuro-immunology fellowship training at the Cleveland Clinic. She is boarded in Neurology and IntegrativeMedicine and is a fellow of the American Academy of Neurology. Dr. Rensel’s work has focused on Adult andPediatric Multiple Sclerosis, Brain health and Integrative Medicine. Her work in academic medicine often intersects with wellness, advocacy, innovation and strategic initiatives. She serves on the steering committee of the National Network of Pediatric MS Centers. She isa “Best Doctor” of Cleveland since 2010 per the Cleveland Magazine. She has served as President of the Women’s Professional Staff Association of the Cleveland Clinic and sits on multiple boards including the Ohio National Multiple Sclerosis Society. She is active as a coach, mentor, scientific reviewer, clinical researcher, activity director, entrepreneur and national speaker. She has also appeared on numerous media outlets, including a spot on Good Morning America.

Dr. Rensel has had articles and abstracts published in peer-reviewed medical journals and has written chapters: "Differential Diagnosis of MS and Clues to Misdiagnosis," in the book entitled Multiple Sclerosis: Diagnosis, Medical Management and Rehabilitation as well as "General Health and Wellness in MS" in the book entitled Multiple Sclerosis and Related Disorders.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Adult Neurology
Cleveland, OH USA

Internship - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Medical College of Ohio at Toledo
Toledo, OH USA

Undergraduate - Gannon University
Erie, PA USA

Additional Training

  • Quality as Value in Healthcare: What do current changes mean? 11/1/12
  • Resonant Leadership: Creating Sustainable Leaders Through Mindfulness, Hope & Compassion, 9/11/12
  • Middle East Cultural Competence: Culture, Patient Care and Working Relationships
  • The Business of Healthcare, 10/12/11
  • Foundations of Healthcare Communication for Physicians, 9/13/11
  • Investigator Human Subject Research Education track 2/17/10
  • Cleveland Clinic Staff Mentorship training 1/ 2010
  • Palatucci Patient Advocacy training 1/2011
  • Engaging Women Leaders: Setting Your Goals , 3/3/09
  • The Science and Clinical Application of Integrative Holistic Medicine , San Diego, CA 11/16-21/08
  • Using Sharepoint CCA 7/24/08
  • Situational Leadership CCA 7/1/08
  • Tools and Tips for Information Management , 10/21/08
  • Patient Experience Within the Revenue Cycle, 11/25/08
  • Writing Educational Objectives, Cleveland Clinic, 2006
  • What the CEO Wants you to Know: Building Business Acumen, Physician Leadership University, Cleveland Clinic, 2006
  • Process Improvement, Physician Leadership University, Cleveland Clinic, 2006
  • Essentials of Clinical Teaching and Assessment Retreat, Cleveland Clinic, 2006
  • Biostatics and Statistical Computing, Cleveland Clinic, 2002
  • Research Methods Module I, Clinical Epidemiology, Cleveland Clinic, 2002
  • Human Research Subjects Protection Training, Cleveland Clinic, 2002

Professional Highlights

  • Network of Pediatric MS Centers Steering Committee
  • Director of Pediatric MS,  Mellen Center
  • Director of Wellness, Mellen Center
  • Principal Investigator of Clinical trials
  • President of Women's Professional Staff Association 2017-2019
  • International Pediatric MS Study Group 2011- Present


  • Psychiatry and Neurology - Neurology

Specialty Interests

Adult Multiple Sclerosis, Pediatric Multiple Sclerosis, Pediatric NMO Wellness for MS patients, Integrative Medicine , NMO, Devics disease Clinical trials , Complementary Alternative Medicine

Awards & Honors

  • Clinical Neurology Award, Medical College of Ohio, 1992
  • Alumni of the Year, St. Francis of Assisi, 2003
  • Distinguished Educator Level I Certificate, ClevelandClinic, 2007
  • Best Doctors of Cleveland, Cleveland Magazine, 2010-present
  • Caregiver Celebration Award, Cleveland Clinic, 2013,2014
  • Mentor Recognition Award, Cleveland Clinic, 2015
  • Service award for Career Development and Coaching, Cleveland Clinic, 2016
  • Outstanding preceptor for Medical students, Cleveland Clinic, 2019

Innovations & Patents

  • BrainMAX


  • American Academy of Neurology, Fellow
  • Diplomate, American Board of Psychiatry and Neurology
  • Board Certification of the American Board of Integrative Holistic Medicine
Research & Publications

Research & Publications

See publications for Mary Rensel, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 10/5/2021, Dr. Rensel has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Rensel receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Biogen Idec, Inc.
  • Novartis Pharmaceuticals Corporation

Fiduciary Role. Dr. Rensel serves in a fiduciary capacity, such as an elected officer, director or chief medical officer, for the following companies or other entities:

  • Brain Fresh, LLC

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

112 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.8

22 Patient Comments

Reviewed on Mar 30, 2022

Dr. Rensel is always very nice and very professional. She answered all my questions and concerns.

Reviewed on Feb 2, 2022

Dr. Rensel is truly the best!

Reviewed on Jan 21, 2022

Dr. Rensel is the most amazing physician I've ever had.

Reviewed on Jan 5, 2022

Dr. Rensel cares about her patients. She listens and comes up with a plan. She treats the whole patient from physical symptoms to mental issues.

Reviewed on Nov 17, 2021

I was very pleased how well the Doctor listened to all my complaints & addressed each of them. She was extremely helpful & willing to take on all my issues & help rectify them

Reviewed on Nov 5, 2021

Dr Rensel was kind and caring. Spent so much time with me and husband. We were very pleased with our appointment.

Reviewed on Oct 22, 2021

Dr Rensel does a great job of always answering any questions or concerns we have. She was great in taking to us about COVID shots. I have been seeing her since 2010 and I will never go to anyone else.

Reviewed on Oct 20, 2021

The doctor was very thorough and listened to me. I felt like my concerns were being heard and addressed. The doctor explained things in language u could understand.

Reviewed on Sep 29, 2021

Excellent care with Dr Rensel!

Reviewed on Sep 22, 2021

It's very hard to find a doctor that you were comfortable with and she is a very good doctor

Reviewed on Aug 27, 2021

Dr. Mary Rensel is wonderful! She takes her time with me and listens to my concerns. I have had MS for forty five years and she really knows and understands . She gave me a book on MS and Brain health which I really loved and appreciated.

Reviewed on Aug 25, 2021

It was a pleasure talking to Dr. Rensel. She listens and I don't feel like I have to hurry up with my thoughts or questions.

Reviewed on Aug 25, 2021

I always have a good experience with this doctor. Always.

Reviewed on Aug 25, 2021

I was glad a virtual visit was doable because my driver wasn't available to take me to the doctor appointment.

Reviewed on Aug 25, 2021

Difficult appointment for me but the physician was excellent and personable. Definitely cares about the care she provided.

Reviewed on Aug 3, 2021

Dr. Rensel took a lot of time with me. I was scheduled for major surgery a week later and she was very concerned and thorough talking to me about everything. She did a wonderful job!

Reviewed on Jul 27, 2021

The doctor listen to what you have to say.

Reviewed on Jul 14, 2021

I had a question for the Dr. And they called me back quick and were very helpful

Reviewed on Jun 25, 2021

Dr Rensel is just awesome. I feel so confident and secure in her care. From the very first moment I met her she was a source of comfort for me; her expertise and her compassion were just what I needed at a difficult time. She has listened to me, given me all the time I have needed, it's just been such a great experience, in spite of a very scary diagnosis and uncertain future. It means the world to me to be in her expert care.

Reviewed on Jun 15, 2021

Dr. Rensel is a blessing to our family. We appreciate her support and guidance.

Reviewed on Jun 4, 2021

Excellent, doctor who really listened to my health concerns, answered my questions and she didn't rush my visit after my being late for my appointment. That kind of treatment goes a long way, my old MS nurse practitioner need some patient interaction and/or communication courses. Then when the doctor you never met, meets you once (by your request) sides with her team instead of trying to cover it up. Cleveland Clinic large staff should provide and require their staff mandatory training.

Reviewed on May 11, 2021

Dr. Rensel is a great listener.

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