Department Mellen Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Consultation and Long-term Care
  • Lumbar Puncture (Spinal Tap)
View all 2 Treatment & Services +

Specialty in Diseases & Conditions

  • Acute Disseminated Encephalomyelitis (ADEM)
  • Devic's Disease (Neuromyelitis Optica)
  • Multiple Sclerosis
  • Neuroimmunology
  • Optic Neuritis
  • Pediatric Multiple Sclerosis
  • Transverse Myelitis
View all 7 Specialties +


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About Mary Rensel, MD

Mary R. Rensel, MD, is a Staff Neurologist in Neuroimmunology at Cleveland Clinic's Mellen Center for Multiple Sclerosis Treatment and Research, where she was appointed in 1998. Dr. Rensel is a Diplomate of the American Board of Psychiatry and Neurology and a fellow of the American Academy of Neurology (AAN).

She is also Board Certified in Integrative Holistic Medicine. She directs the Pediatric MS and the Wellness programming at the Mellen Center.  She is an Assistant  Professor at the Cleveland Clinic Learner College of Medicine where she serves as an instructor for the medical students. She is a coach and mentor at Cleveland Clinic and with the AAN. She is active in clinical research of Pediatric and Adult MS and NMO, she has served as Principle Investigator for many clinical trials.

She serves as the President of the Women's Professional Staff Association of the Cleveland Clinic.  She is an Activity Director of CME courses. She  is a national speaker.

Dr. Rensel has served on the National Multiple Sclerosis Society Pediatric MS Advisory Board and is currently serving on the International Pediatric MS study Group. Since 2001, she has been a participant on the Bureau for Children with Medical Handicaps. Dr. Rensel received the Clinical Neurology Award from the Medical College of Ohio in 1992. She has been named one of the Best Doctors per the Cleveland Magazines since 2010. She serves on community boards; NMSS Buckeye chapter and Chagrin Falls Educational Foundation.

Dr. Rensel has had articles and abstracts published in peer-reviewed medical journals and has written chapters: "Differential Diagnosis of MS and Clues to Misdiagnosis," in the book entitled Multiple Sclerosis: Diagnosis, Medical Management and Rehabilitation as well as "General Health and Wellness in MS" in the book entitled Multiple Sclerosis and Related Disorders.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Adult Neurology
Cleveland, OH USA

Internship - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical School - Medical College of Ohio at Toledo
Toledo, OH USA

Undergraduate - Gannon University
Erie, PA USA

Additional Training

  • Quality as Value in Healthcare: What do current changes mean? 11/1/12
  • Resonant Leadership: Creating Sustainable Leaders Through Mindfulness, Hope & Compassion, 9/11/12
  • Middle East Cultural Competence: Culture, Patient Care and Working Relationships
  • The Business of Healthcare, 10/12/11
  • Foundations of Healthcare Communication for Physicians, 9/13/11
  • Investigator Human Subject Research Education track 2/17/10
  • Cleveland Clinic Staff Mentorship training 1/ 2010
  • Palatucci Patient Advocacy training 1/2011
  • Engaging Women Leaders: Setting Your Goals , 3/3/09
  • The Science and Clinical Application of Integrative Holistic Medicine , San Diego, CA 11/16-21/08
  • Using Sharepoint CCA 7/24/08
  • Situational Leadership CCA 7/1/08
  • Tools and Tips for Information Management , 10/21/08
  • Patient Experience Within the Revenue Cycle, 11/25/08
  • Writing Educational Objectives, Cleveland Clinic, 2006
  • What the CEO Wants you to Know: Building Business Acumen, Physician Leadership University, Cleveland Clinic, 2006
  • Process Improvement, Physician Leadership University, Cleveland Clinic, 2006
  • Essentials of Clinical Teaching and Assessment Retreat, Cleveland Clinic, 2006
  • Biostatics and Statistical Computing, Cleveland Clinic, 2002
  • Research Methods Module I, Clinical Epidemiology, Cleveland Clinic, 2002
  • Human Research Subjects Protection Training, Cleveland Clinic, 2002

Professional Highlights

  • Network of Pediatric MS Centers Steering Committee
  • Director of Pediatric MS,  Mellen Center
  • Director of Wellness, Mellen Center
  • Principal Investigator of Clinical trials
  • President of Women's Professional Staff Association
  • International Pediatric MS Study Group 2011- Present


  • Neurology

Specialty Interests

Adult Multiple Sclerosis, Pediatric Multiple Sclerosis, Pediatric NMO Wellness for MS patients, Integrative Medicine , NMO, Devics disease Clinical trials , Complementary Alternative Medicine

Awards & Honors

  • College of Ohio Clinical Neurology Award 1992
  • Alumni of the Year, St. Francis of Assisi 2003
  • Distinguished Educator Level I Certificate awarded 2007
  • Best Doctors of Cleveland 2010 -2013, Cleveland Magazine
  • Caregiver Celebration Award 2013

Innovations & Patents

  • BrainMAX


  • American Academy of Neurology, Fellow
  • Diplomate, American Board of Psychiatry and Neurology
  • Board Certification of the American Board of Integrative Holistic Medicine
Research & Publications

Research & Publications

See publications for Mary Rensel, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 8/14/2018, Dr. Rensel has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Rensel receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Novartis Pharmaceuticals Corporation
  • Teva Neuroscience
  • Biogen Idec, Inc.
  • Sanofi Genzyme

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

122 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Listens 4.9
Courtesy, Respect & Concern 5
Knows Medical History 4.7
Time Spent with Patient 4.8
Patient Rating of Doctor 4.8

12 Patient Comments

Reviewed on Oct 24, 2018

love Dr rensel. she was kind and attentive. she made sure to address my wife's concerns and questions about my condition as well.

Reviewed on Oct 22, 2018

good experience at Cleveland clinic. dr and staff very friendly

Reviewed on Sep 19, 2018

The Hillcrest Cleveland Clinic office is very convenient for me and I am so happy that Dr. Rensel sees patients at this location. The entire staff at Dr. Rensel's Office here is extremely organized, professional, and courteous. I am always greeted warmly.

Reviewed on Sep 19, 2018

Dr. Rensel always spends whatever time is necessary to discuss my condition with me and to give me thorough explanations of my options. I feel that I am getting the best. possible care with her. She answers every one of my questions(I bring lists of questions) and never rushes me through my appointment.

Reviewed on Sep 5, 2018

my doctor was very attentive, patient and compassionate about my rare disorder. She treated me with respect and made sure to answer all off my concerns.I have worked in health care for 44 years in Ashtabula and am fortunate to have as part of my medical team.

Reviewed on Sep 5, 2018

Overall my experience with the doctor and staff was excellent. The wait time was about 40 minutes overall so a little long. My biggest complaint is with scheduling appointments because when you call, you first connect with an operator who then directs your call. I'm always on hold at least 5 to 10 minutes and sometimes longer. I wish you could call and set up appointments directly with the office.

Reviewed on Aug 27, 2018

Dr. Rensel did a great job listening to to me and spending time answering my questions. I didn't feel like she was in a rush to move on to the next appointment and I appreciated that.

Reviewed on Aug 13, 2018

There was no wait time. Dr. Rensel came to waiting area and escorted me into the exam room with the medical student. It was wonderful personal treatment.

Reviewed on Jul 31, 2018

This was my first time seeing Dr. Rensel. She was 45 minutes late. She spent around an hour with me, but it still seemed rushed.

Reviewed on May 30, 2018

I was in a bind, my M.S. was acting up, and I'm scheduled for aneurysm surgery with Dr. Anthony Rizzo on 6/19 My M.S. affects my optic nerve and migraines. I mentioned to my retinal specialist, Dr. Daniel Weidenthal that I'm concerned about the upcoming surgery, but my neurologist of over 20 years, Dr. Joseph Zayat had just retired from CCF. Dr. Weidenthal asked his peers about finding me a new neurologist, and Dr. Rensfel was suggested. Dr. Weidenthal wrote a short medical history on me to give to Dr. Resfel, and I was pleased with her services

Reviewed on Apr 4, 2018

My doctor was Dr. Zayat. When he retired, he recommended Dr Rensel and she is magnificent. She was superb and helped me in every way possible.

Reviewed on Mar 7, 2018

Dr. Rensel explained my treatment options thoroughly. She was very clear and gave me more than ample opportunities to ask questions.

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