Hyperinsulinemia happens when you have a higher amount of insulin in your blood than what's considered normal due to insulin resistance. Your pancreas has to work harder to manage your blood sugar levels by releasing extra insulin.
Hyperinsulinemia happens when you have a higher amount of insulin in your blood than what's considered normal. Insulin is a hormone your pancreas makes and releases that’s essential for life and for regulating blood glucose (sugar) levels, specifically by lowering glucose levels.
In most cases, hyperinsulinemia results from insulin resistance, which happens when cells in your muscles, fat and liver don’t respond as they should to insulin. The development of insulin resistance typically increases insulin production (hyperinsulinemia) so that your body can maintain healthy blood sugar levels.
If a person has excess insulin in their body and doesn’t have insulin resistance, it would cause low blood sugar (hypoglycemia). In the case of hyperinsulinemia due to insulin resistance, excess insulin doesn’t cause low blood sugar.
Due to the similarity in their names, people often confuse hyperinsulinemia with hyperinsulinism. Hyperinsulinism is a different condition that happens when a person has excess insulin in their blood due to an issue with their pancreas. This could be a tumor that produces excess insulin called an insulinoma or a congenital condition (a condition you’re born with) in which a gene mutation causes excess insulin production. Unlike hyperinsulinemia, hyperinsulinism causes low blood sugar.
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Hyperinsulinemia caused by insulin resistance can affect anyone, and it can be temporary or chronic. The two main factors that seem to contribute to insulin resistance and hyperinsulinemia are excess body fat, especially around your belly, and a lack of physical activity.
Since there are no common tests to check for hyperinsulinemia and there are no symptoms until insulin resistance turns into prediabetes or Type 2 diabetes, the best way to measure the prevalence of hyperinsulinemia is through the number of prediabetes cases. More than 84 million adults in the United States have prediabetes. That’s about one out of every three adults.
In addition to prediabetes and Type 2 diabetes, hyperinsulinemia is associated with the following conditions:
You may have no noticeable symptoms of hyperinsulinemia that results from insulin resistance. This is because your pancreas is able to produce enough insulin to overcome the resistance. However, chronic insulin resistance and hyperinsulinemia often result in prediabetes and Type 2 diabetes.
Many people have no symptoms of prediabetes, often for years, but some people with prediabetes may experience the following symptoms:
Symptoms of Type 2 diabetes include:
If you’re experiencing any of these symptoms, it’s important to see your healthcare provider.
Insulin resistance is the primary cause of hyperinsulinemia. Because your body is not using insulin properly with insulin resistance, your pancreas has to release extra insulin to try to keep your blood sugar levels in a healthy range.
Hyperinsulinemia can be tricky to diagnose since it often doesn’t have any symptoms unless it results in prediabetes or Type 2 diabetes. There’s also no common test to check for excess insulin levels specifically, especially since insulin levels can vary widely throughout the day.
Since there’s no single test that can directly diagnose hyperinsulinemia, your healthcare provider will consider several factors when assessing the condition, including your:
Since not all factors that contribute to hyperinsulinemia can be treated, such as genetic factors and age, lifestyle modifications are the primary treatment for hyperinsulinemia. Lifestyle modifications include:
Bariatric surgery for people with class III obesity results in a rapid correction of hyperinsulinemia within one week of surgery. In addition, insulin sensitivity improves between six and 24 months after surgery. However, not everyone is a good candidate for bariatric surgery. Talk to your healthcare provider about treatment options that are right for you.
Insulin resistance — and the subsequent hyperinsulinemia — has several causes and contributing factors. Lifestyle changes, such as eating a healthy diet, exercising regularly and losing excess weight, can increase insulin sensitivity and decrease insulin resistance and hyperinsulinemia. But not all causes are reversible.
Talk you your healthcare provider about what you can do to best manage insulin resistance and hyperinsulinemia.
Certain genetic and lifestyle risk factors make it more likely that you’ll develop hyperinsulinemia. Risk factors include:
The prognosis (outlook) of hyperinsulinemia depends on several factors, including:
People can have mild insulin resistance and hyperinsulinemia that never turn into prediabetes or Type 2 diabetes. People can also have insulin resistance and hyperinsulinemia that’s reversible or very manageable with lifestyle changes.
If hyperinsulinemia results in Type 2 diabetes, it’s important to do your best to manage the condition to prevent possible complications.
If you’ve been diagnosed with hyperinsulinemia or conditions related to insulin resistance and hyperinsulinemia, it’s important to see your healthcare provider regularly to make sure your blood sugar levels are in a healthy range and that your treatment is working.
If you’re experiencing symptoms of high blood sugar or prediabetes, contact your provider. They can run simple tests to check your blood sugar levels.
A note from Cleveland Clinic
Hyperinsulinemia is a potentially harmful condition that’s usually the result of insulin resistance. Since it doesn’t have any symptoms until it turns into prediabetes or Type 2 diabetes, the best thing you can do is try to prevent and reverse insulin resistance and hyperinsulinemia by maintaining a healthy weight, exercising regularly and eating a healthy diet.
Last reviewed by a Cleveland Clinic medical professional on 09/20/2022.
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