The most common symptoms are painful urination (dysuria), more frequent urination, and a frequent urge to urinate. Some feel as if their bladder is constantly full or experience abdominal discomfort. Men may feel a fullness in their rectum. Other symptoms are less frequent. Urine may appear milky or cloudy. Reddish or bloody urine (hemorrhagic cystitis) will be present in perhaps 10% of those with a UTI.

Infections that progress from the lower to the upper urinary tract and kidney may create fevers, chills and a malaise or feeling of general discomfort, distress and uneasiness. Some may feel pain in their flank between the ribs and hipbone. This is not the location of the infection. The pain appears here because of the way nerves weave from the urinary tract though the spine.