Ciprofloxacin Injection

What is this medication?

CIPROFLOXACIN (sip roe FLOX a sin) treats infections caused by bacteria. It belongs to a group of medications called quinolone antibiotics. It will not treat colds, the flu, or infections caused by viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Cipro

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Bone problems
• Diabetes
• Heart disease
• High blood pressure
• History of irregular heartbeat
• History of low levels of potassium in the blood
• Joint problems
• Kidney disease
• Liver disease
• Mental illness
• Myasthenia gravis
• Seizures
• Tendon problems
• Tingling of the fingers or toes, or other nerve disorder
• An unusual or allergic reaction to ciprofloxacin, other antibiotics or medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

The medication is for infusion into a vein. It is usually given in a hospital or clinic.

If you get this medication at home, you will be taught how to prepare and give this medication. Use exactly as directed. Take your medication at regular intervals. Do not take your medication more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team regarding the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

• Cisapride
• Dronedarone
• Flibanserin
• Lomitapide
• Pimozide
• Thioridazine
• Tizanidine

This medication may also interact with the following:

• Birth control pills
• Caffeine
• Certain medications for diabetes, like glipizide, glyburide, or insulin
• Certain medications that treat or prevent blood clots like warfarin
• Clozapine
• Cyclosporine
• Dofetilide
• Duloxetine
• Lidocaine
• Methotrexate
• NSAIDS, medications for pain and inflammation, like ibuprofen or naproxen
• Olanzapine
• Omeprazole
• Other medications that prolong the QT interval (cause an abnormal heart rhythm)
• Phenytoin
• Probenecid
• Ropinirole
• Sildenafil
• Theophylline
• Ziprasidone
• Zolpidem

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Do not treat diarrhea with over-the-counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if the diarrhea is severe and watery.

Check with your care team if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medication.

This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
• Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
• Joint, muscle, or tendon pain, swelling, or stiffness
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
• Pain, tingling, or numbness in the hands or feet
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth
• Seizures
• Severe diarrhea, fever
• Sudden or severe chest, back, or stomach pain
• Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Diarrhea
• Dry mouth
• Headache
• Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

If you are using this medication at home, you will be instructed on how to store this medication. Throw away any unused medication after the expiration date on the label.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.