Coma & Persistent Vegetative State


What is a coma?

A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

Is there any treatment for a coma?

Once an individual is out of immediate danger, the medical care team focuses on preventing infections and maintaining a healthy physical state. This will often include preventing pneumonia and bedsores and providing balanced nutrition. Physical therapy may also be used to prevent contractures (permanent muscular contractions) and deformities of the bones, joints, and muscles that would limit recovery for those who emerge from coma.

What is the prognosis (outlook) for a coma?

The outcome for coma and persistent vegetative state depends on the cause, severity, and site of neurological damage. Individuals may emerge from coma with a combination of physical, intellectual, and psychological difficulties that need special attention. Recovery usually occurs gradually, with some acquiring more and more ability to respond. Some individuals never progress beyond very basic responses, but many recover full awareness. Individuals recovering from coma require close medical supervision. A coma rarely lasts more than 2 to 4 weeks. Some patients may regain a degree of awareness after persistent vegetative state. Others may remain in that state for years or even decades. The most common cause of death for someone in a persistent vegetative state is infection, such as pneumonia.

What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct research related to coma in their laboratories at the NIH and also support additional research through grants to major medical institutions across the country. Much of this research focuses on finding better ways to prevent and treat coma.



Brain Injury Association of America, Inc.

1608 Spring Hill Rd., Suite 110

Vienna, VA 22182

Phone: 703.761.0750

Toll-free: 800.444.6443



Brain Trauma Foundation

1999 South Bascom Avenue, Suite 1040

Campbell, CA 95008

Phone: 408.369.9735



Coma/Traumatic Brain Injury Recovery Association, Inc.

8300 Republic Airport, Suite 106

Farmingdale, NY 11735

Phone: 631-756-1826

Family Caregiver Alliance/ National Center on Caregiving

785 Market St., Suite 750

San Francisco, CA 94103

Phone: 415.434.3388

Toll-free: 800.445.8106

Fax: 415.434.3508



National Rehabilitation Information Center (NARIC)

8400 Corporate Drive, Suite 500

Landover, MD 20785

Phone: 301.459.5900

Toll-free: 800.346.2742

TTY: 301.459.5984



Source: National Institutes of Health; National Institute of Neurological Disorders and Stroke*

Last reviewed by a Cleveland Clinic medical professional on 06/21/2018.

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