It emphasizes integrative and evidence-based molecular genetic pathology practice. Rotations in diverse clinical genetics and clinical laboratory settings, extensive involvement in molecular genetic laboratory test utilization, and instruction in molecular laboratory management are integral components of the program.

The Molecular Pathology Department’s faculty members are well-qualified and authorities in various subspecialties of pathology and genetics. Additionally, we partner with the Cleveland Clinic Genomic Medicine Institute, which has a staff of expert clinical geneticists.

The fellow in the Molecular Genetic Pathology fellowship should, at the end of his/her fellowship, have competence in the principles, technical steps and interpretation of procedures performed in the laboratory, including:

  1. Nucleic acid isolation both manual and robotic
  2. Nucleic acid quantification
  3. Primer selection
  4. PCR
  5. RT-PCR
  6. Agarose and capillary gel electrophoresis
  7. Quantitative real-time PCR
  8. Sanger DNA sequencing
  9. NextGeneration sequencing
  10. Invader assay
  11. Pyrosequencing
  12. Genotyping by melting curve analysis
  13. Methylation (bisulfite treatment) studies
  14. Southern blot analysis
  15. Allele specific PCR
  16. Methylation specific primer (MSP)-PCR
  17. DNA:RNA hybrid capture
  18. FISH
  19. Surgical pathology skills in selection of optimal block and region within the block to meet the sensitivity criteria for mutation testing.

Hands-on molecular genetic laboratory experience is an important part of the learning experience in Molecular Pathology. The fellow should have hands-on experience with the following molecular pathology skills and techniques, if he / she has not already had adequate laboratory experience with them prior to beginning the Molecular Genetic Pathology fellowship. These tests and skills represent the minimal hands-on laboratory experience for a fellow in the Cleveland Clinic program.

  1. DNA/RNA extraction from either liquid samples (e.g., blood) or tissue
  2. Nucleic acid quantification
  3. PCR
  4. Agarose and capillary gel electrophoresis
  5. FISH

Duration

  • One, one-year ACGME-accredited fellowship.

Responsibilities

  • Active participation in the integrative aspects of the molecular pathology practice.
  • Perform basic molecular techniques, test validation and implementation, molecular test utilization and triaging, translational research and scientific publication, clinical informatics and laboratory management.
  • Review test results, draft/review preliminary test interpretation, and sign-out with staff on service.
  • Generate integrative reports and provide interface among the different sections of the institute and other specialty practices.
  • Involvement in clinical diagnostic management using clinical bioinformatics, genetic test consent and interpretation, and genetic counseling of patients with genetic disorders.
  • Participate in educational activities within the department, the Institute and Cleveland Clinic.

Requirements

  • Completion of an ACGME-accredited Clinical Pathology or combined Anatomic/Clinical Pathology or Clinical Genetics residency.

Application

Contacts

Fellowship Program Director (Interim)
Marvin Natowicz, MD, PhD
216.445.3735
natowim@ccf.org

Program Coordinator
Paul Suchy, DM, MSM
Administrator, Center for Pathology Education
Robert J. Tomsich Pathology and Laboratory Medicine Institute
Cleveland Clinic
9500 Euclid Avenue, L-21
Cleveland, OH 44195
Telephone: 216.636.5843
Fax: 216.445.9535
suchyp@ccf.org