Surgical and medical treatments for acute intracerebral hemorrhage are studied by the multidisciplinary team at Cleveland Clinic's Cerebrovascular Center. Minimally invasive method using BrainPath is one approach studied at the center. Neurocritical care and stroke sections study pharmacologic approaches to acute intracerebral hemorrhage.

Contact Person

Mark Bain, MD (Surgical)

Ken Uchino, MD (Medical)



Reversal of Coagulopathy Using Prothrombin Complex Concentrates is Associated with Improved Outcome Compared to Fresh Frozen Plasma in Warfarin-Associated Intracranial Hemorrhage. Frontera JA, Gordon E, Zach V, Jovine M, Uchino K, Hussain MS, Aledort L. Neurocrit Care. 2014 Mar 27.

Pre-hospital reversal of warfarin-related coagulopathy in intracerebral hemorrhage in a mobile stroke treatment unit. Gomes J, Ahrens C, Hussain MS, Winners S, Rasmussen PA, Uchino K. Stroke. 2015;46(5):e118-20. doi: 10.1161/STROKEAHA.115.008483. Epub 2015 Apr 14. PMID: 25873600

Minimally Invasive Hemorrhage Evacuation.Moore NZ, Bain M. World Neurosurg. 2016 May;89:713-5. doi: 10.1016/j.wneu.2016.03.070. Epub 2016 Mar 26. PMID: 27020973.

Initial Single-Center Technical Experience With the BrainPath System for Acute Intracerebral Hemorrhage Evacuation. Bauer AM, Rasmussen PA, Bain MD. Oper Neurosurg (Hagerstown). 2017 Feb 1;13(1):69-76. doi: 10.1227/NEU.0000000000001258. PMID: 28931255.

BrainPath-Mediated Resection of a Ruptured Subcortical Arteriovenous Malformation. Witek AM, Moore NZ, Sebai MA, Bain MD. Oper Neurosurg (Hagerstown). 2018 Jul 1;15(1):32-38. doi: 10.1093/ons/opx186. PMID: 28961981.

Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage. Buletko AB, Thacker T, Cho SM, Mathew J, Thompson NR, Organek N, Frontera JA, Uchino K. Neurology. 2018 Aug 10. pii: 10.1212/WNL.0000000000006156. doi: 10.1212/WNL.0000000000006156. [Epub ahead of print] PMID: 30097480

Members & Collaborations