Overview
The members of the neurocritical care and endovascular sections of the Cerebrovascular Center are interested in the management of subarachnoid hemorrhage, in particular, prevention and treatment of vasospasm. A major effort of this group, led by Dr. Joao Gomes, is a prospective study to understand the role of heme-iron and its metabolites in cerebrospinal fluid as the cause of oxidative damage and vasospasm. Other studies include investigating intraventricular milrinone as a treatment for vasospasm and operational studies to understand how early mobilization in the ICU can improve long-term outcomes after subarachnoid hemorrhage.
Contact Information
Funding
Aneurysm & AVM Foundation, Ceruloplasmin concentration and ferroxidase activity in CSF and risk of brain injury after aSAH. Joao Gomes (PI). 2017-2018.
Publications
Brain iron metabolism and brain injury following subarachnoid hemorrhage: iCeFISH-pilot (CSF iron in SAH).Gomes JA, Selim M, Cotleur A, Hussain MS, Toth G, Koffman L, Asi K, Provencio JJ. Neurocrit Care. 2014 Oct;21(2):285-93. doi: 10.1007/s12028-014-9977-8. PMID: 24710655.
Hematologic counts as predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Da Silva IRF, Gomes JA, Wachsman A, de Freitas GR, Provencio JJ. J Crit Care. 2017 Feb;37:126-129. doi: 10.1016/j.jcrc.2016.09.011. Epub 2016 Sep 22. PMID: 27718411.
The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage. Frontera JA, Provencio JJ, Sehba FA, McIntyre TM, Nowacki AS, Gordon E, Weimer JM, Aledort L. Neurocrit Care. 2017 Feb;26(1):48-57. doi: 10.1007/s12028-016-0292-4. PMID: 27430874
Improvement in Sonographic Vasospasm Following Intravenous Milrinone in a Subarachnoid Hemorrhage Patient with Normal Cardiac Function.Katyal N, George P, Nattanamai P, Raber LN, Beary JM, Newey CR. Cureus. 2018;10(7):e2916. PMID: 30186721.
Members & Collaborations
Cleveland Clinic
- Joao Gomes, MD
- Dhimant Dani, MD
- Mark Bain, MD
- Christine Ahrens, PharmD
External Relationships and Collaborations
- Leah P. Shriver, PhD
Assistant Professor, Department of Chemistry, University of Akron - Christopher J. Ziegler, PhD
Professor, Department of Chemistry, University of Akron
