While cardiac sources of embolism and extracranial arterial disease have been studied extensively, non-atherosclerotic intracranial vascular disease is an uncommon cause of stroke that remains understudied. High-resolution vessel wall MRI imaging has allowed better characterization of the patterns of vascular lesion beyond luminal narrowing.

We use banked serum and cerebrospinal fluid samples to conduct proteomics or deep sequencing studies to understand the infectious and inflammatory causes of intracranial vasculopathies. In collaboration with Rula Hajj-Ali, MD and Leonard Calabrese, DO at the Center for Vasculitis Care and Research at Cleveland Clinic, a registry has been established to collect data.

Contact Information

Ken Uchino, MD



Catastrophic Reversible Cerebral Vasoconstriction Syndrome associated with Serotonin Syndrome. John S, Donnelly M, Uchino K. Headache. 2013;53(9):1482-7

High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. Obusez EC, Hui F, Hajj-Ali RA, Cerejo R, Calabrese LH, Hammad T, Jones SE. AJNR Am J Neuroradiol. 2014 Aug;35(8):1527-32. doi: 10.3174/ajnr.A3909. Epub 2014 Apr 10. PMID: 24722305

Reversible Cerebral Vasoconstriction Syndrome- Is it more than just cerebral vasoconstriction?John S, Hajj-Ali R, Min D, Calabrese L, Cerejo R, Uchino K. Cephalalgia. 2015;35(7): 631–634

High-Resolution MRI Vessel Wall Imaging in Varicella Zoster Virus Vasculopathy.Cheng-Ching E, Jones S, Hui FK, Man S, Gilden D, Bhimraj A, Uchino K. J Neurol Sci. 2015 Feb 16. [Epub ahead of print]

COL4A1 gene mutation- beyond a vascular syndrome. John S, Jehi L, Manno E, Conway D, Uchino K. Seizure. 2015;31:19-21. Available online 4 July 2015

Long-term outcomes of patients with Reversible Cerebral Vasoconstriction Syndrome.John S, Singhal AB, Calabrese L, Uchino K, Hammad T, Tepper S, Stillman M, Mills B, Thankachan T, Hajj-ali RA. Cephalalgia. 2016;36(4):387-94. [Epub ahead of print 2015 Jun 18] DOI: 10.1177/0333102415591507

Intravascular Lymphoma Mimics Central Nervous System Vasculitis on High-Resolution Vessel Wall MRI.Schaafsma JD, Hui F, Wisco D, Staugaitis SM, Uchino K, Kozumitcheva E, Jaigobin C, Hazrati LN, Mikulis DJ, Mandell DM. Clinical Neuroradiology. 2017;27(1):105-108. PMID: 27530660

Homocysteinuria due to cystathionine β-synthase deficiency manifesting as Moyamoya vasculopathy and Henoch Schonlein Purpura. Cho SM, Di Lorenzo R, Myles J, Uchino K. Neurology. 2018. [Epub ahead of print 2018 Jul 18] PMID: 30021915.

Members & Collaborations

Members & Collaborations

Cleveland Clinic

External Relationships and Collaborations

  • Aneesh Singhal, MD, Massachusetts General Hospital