The members of the research group have an interest in stroke complications from surgery, procedures, and acute medical diseases. Research is being conducted in collaboration with specialists outside of neurology and neurosurgery. In collaboration with the Heart, Vascular & Thoracic Institute at the Cleveland Clinic, stroke complications of left ventricular assist devices, the Impella intracardiac pump, and transcatheter aortic valve implantations are being investigated in order to understand predictors, timing, and acute treatment of stroke complications. In addition, neurologic complications that occur in infective endocarditis are being investigated from a neurologic perspective, with emphasis on imaging and infectious intracranial aneurysms.

Contact Information

Ken Uchino, MD



Risk factors, mortality, and timing of ischemic and hemorrhagic stroke with left ventricular assist devices. Frontera JA, Starling R, Cho SM, Nowacki AS, Uchino K, Hussain MS, Mountis M, Moazami N. J Heart Lung Transplant. 2016. 2498(16)30470-3. [Epub ahead of print 2016 Dec 23]. PMID: 28110971

Infective Endocarditis Strokes and Imaging Characteristics (IESIC) group.  Magnetic Resonance Imaging Susceptibility-Weighted Imaging Lesion and Contrast Enhancement May Represent Infectious Intracranial Aneurysm in Infective Endocarditis. Cho SM, Rice C, Marquardt RJ, Zhang LQ, Khoury J, Thatikunta P, Buletko AB, Hardman J, Uchino K, Wisco D;   Cerebrovasc Dis. 2017;44(3-4):210-216. doi: 10.1159/000479706. PMID: 28848178

Radiographic and Clinical Brain Infarcts in Cardiac and Diagnostic Procedures: A Systematic Review and Meta-Analysis. Cho SM, Deshpande A, Pasupuleti V, Hernandez AV, Uchino K. Stroke. 2017 ;48(10):2753-2759. [Epub ahead of print 2017 Sept 15] PMID: 28916673

Radiographic and symptomatic brain ischemia in CEA and CAS: A systematic review and meta-analysis. Cho SM, Deshpande A, Pasupuleti V, Hernandez AV, Uchino K. Neurology. 2017;89(19):1977-1984. [Epub ahead of print 2017 Oct 11] PMID: 29021357

Cerebral Microbleeds Predict Infectious Intracranial Aneurysm in Infective Endocarditis. Cho SM, Marquardt RJ, Rice CJ, Buletko AB, Zhang LQ, Khoury J, Thatikunta P, Hardman J, Wisco D, Uchino K. Eur J Neurol. 2018; 25:970–975. [Epub ahead of print 2018 Mar 30] PMID: 29603515

The Impact of Infection and Elevated INR in Left Ventricular Assist Device-Associated Intracranial Hemorrhage: A Case-Crossover Study. Cho SM, Lee T, Starling RC, Thompson NR, Uchino K. ASAIO Journal, in press.

What Causes Left Ventricular Assist Device-Associated Ischemic Stroke? Surgery, Pump Thrombosis, Antithrombotics, and Infections.Cho SM, Hassett C, Rice C, Starling R, Katzan I, Uchino K. ASAIO Journal, in press.

The Management of Acute Ischemic Strokes and the Prevalence of Large Vessel Occlusion in Left Ventricular Assist Device. Rice CJ, Cho SM, Zhang LQ, Hassett C, Starling RC, Uchino K. Cerebrovasc Dis. 2018;46(5-6):213-217. PMID: 30513514.

MRI Presentation of Infectious Intracranial Aneurysms in Infective Endocarditis.Migdady I, Rice CJ, Hassett C, Zhang LQ, Wisco D, Uchino K, Cho SM. Neurocrit Care. 2019;30(3):658-665. PMID: 30519794.

Acute Ischemic Stroke Therapy in Infective Endocarditis: Case Series and Systematic Review. Marquardt RJ, Cho SM, Thatikunta P, Deshpande A, Wisco D, Uchino K. J Stroke Cerebrovasc Dis. 2019;28(8):2207-2212. PMID: 31129109.

Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment. Rice CJ, Cho SM, Marquardt RJ, Zhang LQ, Khoury J, Hardman J, Wisco D, Hussain MS, Uchino K. J Neurol Sci. 2019 15;403:50-55. PMID: 31220742.

Members & Collaborations

Members & Collaborations

Cleveland Clinic

External Relationships and Collaborations

  • Sung-Min Cho, DO
    Assistant Professor, Departments of Neurology, Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine
  • Adrian V Hernandez-Diaz, MD PhD
    Associate Professor of Comparative Effectiveness and Outcomes Research, Department of Pharmacy Practice, University of Connecticut