Cleveland Clinic was 4th in the world (2nd in the United States) to start a mobile stroke unit for pre-hospital stroke treatment. Since 2014, the Cleveland Clinic Mobile Stroke Treatment Unit (MSTU) has provided pre-hospital thrombolysis for acute ischemic stroke.

The Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) study group is part of the international mobile stroke unit collaboration—Pre-Hospital Stroke Treatment Organization (PRESTO). The research group has been studying the time efficiency, patient outcomes, and health economics of this novel mode of stroke treatment.

Contact Person

Ken Uchino, MD



Pre-hospital reversal of warfarin-related coagulopathy in intracerebral hemorrhage in a mobile stroke treatment unit.
Gomes J, Ahrens C, Hussain MS, Winners S, Rasmussen PA, Uchino K.
Stroke. 2015;46(5):e118-20. doi: 10.1161/STROKEAHA.115.008483. Epub 2015 Apr 14. No abstract available.
PMID: 25873600

A Mobile Stroke Treatment Unit for Field Triage of Patients for Intraarterial Revascularization Therapy.
Cerejo R, John S, Buletko AB, Taqui A, Itrat A, Organek N, Cho SM, Sheikhi L, Uchino K, Briggs F, Reimer AP, Winners S, Toth G, Rasmussen P, Hussain MS.
J Neuroimaging. 2015 Nov-Dec;25(6):940-5. doi: 10.1111/jon.12276. Epub 2015 Jul 14.
PMID: 26179631

Brain Imaging Using Mobile CT: Current Status and Future Prospects.
John S, Stock S, Cerejo R, Uchino K, Winners S, Russman A, Masaryk T, Rasmussen P, Hussain MS.
J Neuroimaging. 2016 Jan-Feb;26(1):5-15. doi: 10.1111/jon.12319. Epub 2015 Nov 23. Review.
PMID: 26593629

Telemedicine in Prehospital Stroke Evaluation and Thrombolysis: Taking Stroke Treatment to the Doorstep.
Itrat A, Taqui A, Cerejo R, Briggs F, Cho SM, Organek N, Reimer AP, Winners S, Rasmussen P, Hussain MS, Uchino K; Cleveland Pre-Hospital Acute Stroke Treatment Group.
JAMA Neurol. 2016 Feb;73(2):162-8. doi: 10.1001/jamaneurol.2015.3849.
PMID: 26641366

Performance of CT Angiography on a Mobile Stroke Treatment Unit: Implications for Triage.
John S, Stock S, Masaryk T, Bauer A, Cerejo R, Uchino K, Winners S, Rasmussen P, Hussain MS.
J Neuroimaging. 2016 Jul;26(4):391-4. doi: 10.1111/jon.12346. Epub 2016 Mar 30.
PMID: 27028362

Reduction in time to treatment in prehospital telemedicine evaluation and thrombolysis.
Taqui A, Cerejo R, Itrat A, Briggs FB, Reimer AP, Winners S, Organek N, Buletko AB, Sheikhi L, Cho SM, Buttrick M, Donohue MM, Khawaja Z, Wisco D, Frontera JA, Russman AN, Hustey FM, Kralovic DM, Rasmussen P, Uchino K, Hussain MS; Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) Group.
Neurology. 2017 Apr 4;88(14):1305-1312. doi: 10.1212/WNL.0000000000003786. Epub 2017 Mar 8.
PMID: 28275084

The PRE-hospital Stroke Treatment Organization.
Audebert H, Fassbender K, Hussain MS, Ebinger M, Turc G, Uchino K, Davis S, Alexandrov A, Grotta J; PRESTO Group.
Int J Stroke. 2017 Dec;12(9):932-940. doi: 10.1177/1747493017729268. Epub 2017 Sep 5. Review.
PMID: 28872449

Members & Collaborations

Members & Collaborations

Cleveland Clinic

External Relationships and Collaborations

  • Jon Schrock, MD
    Department of Emergency Medicine, MetroHealth; Associate Professor of Emergency Medicine, Case Western Reserve University
  • Farren Briggs, PhD
    Assistant Professor, Department of Population and Quantitative Health Sciences, Case Western Reserve University